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製品番号: HY-123411

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MGS0039

(別名: BCI 632)

MGS0039 is a type II group mGluR antagonist. MGS0039 has a high affinity for mGluR2 and mGluR3, with K_i values of 2.2 nM and 4.5 nM, respectively. MGS0039 can attenuate the inhibitory effect of glutamate-induced cyclic AMP formation triggered by Forskolin (HY-15371) in CHO cells expressing mGluR2/mGluR3. MGS0039 shows antidepressant-like activity in rats.

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CAS 番号: 569686-87-9
分子式: C₁₅H₁₄Cl₂FNO₅
分子量:378.18

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

MGS0039 構造式

CAS 番号: 569686-87-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

mGluR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	>100000 nM Compound: (-)-11be	Effective concentration for agonistic activity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells	[PMID: 15317467]
CHO	EC₅₀	>100000 nM Compound: (-)-11be	Effective concentration for agonistic activity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells	[PMID: 15317467]
CHO	EC₅₀	>100000 nM Compound: (-)-11be	Effective concentration for agonistic activity towards metabotropic glutamate receptor 5 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 5 of rat expressed in CHO cells	[PMID: 15317467]
CHO	EC₅₀	>100000 nM Compound: (-)-11be	Effective concentration for agonistic activity towards metabotropic glutamate receptor 6 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 6 of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	11700 nM Compound: (-)-11be	Concentration required to inhibit metabotropic glutamate receptor 5 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 5 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	1740 nM Compound: (-)-11be	Concentration required to inhibit metabotropic glutamate receptor 4 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 4 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	20 nM Compound: (-)-11be	Concentration required to inhibit metabotropic glutamate receptor 2 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 2 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	2060 nM Compound: (-)-11be	Concentration required to inhibit metabotropic glutamate receptor 6 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 6 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	24 nM Compound: (-)-11be	Concentration required to inhibit metabotropic glutamate receptor 3 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 3 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	93300 nM Compound: (-)-11be	Concentration required to inhibit metabotropic glutamate receptor 1 activity of rat expressed in CHO cells Concentration required to inhibit metabotropic glutamate receptor 1 activity of rat expressed in CHO cells	[PMID: 15317467]
CHO	EC₅₀	>100000 nM Compound: (-)-11be	Effective concentration for agonistic activity towards metabotropic glutamate receptor 1 of rat expressed in CHO cells Effective concentration for agonistic activity towards metabotropic glutamate receptor 1 of rat expressed in CHO cells	[PMID: 15317467]
CHO	IC₅₀	20 nM Compound: MGS0039	Antagonist activity at mGLUR2 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production Antagonist activity at mGLUR2 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production	[PMID: 22318160]
CHO	IC₅₀	24 nM Compound: MGS0039	Antagonist activity at mGLUR3 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production Antagonist activity at mGLUR3 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production	[PMID: 22318160]

化学情報

CAS 番号 569686-87-9
分子量 378.18
分子式 C₁₅H₁₄Cl₂FNO₅
SMILES

O=C(O)[C@]1([C@@]2([C@](F)([C@@]2(C[C@H]1OCC3=CC=C(C(Cl)=C3)Cl)[H])C(O)=O)[H])N
別名

BCI 632
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Chaki S, et al. MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity. Neuropharmacology. 2004 Mar;46(4):457-67. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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MGS0039

mGluR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

MGS0039 関連分類

HY-123411 関連分類