NSC156565
NSC156565 is a Pycsar immune system inhibitor and phage infection potentiator. NSC156565 blocks PycTM cytotoxic effects via prevention of 3′,5′-cCMP-mediated activation or inhibition of activated effector membrane-perturbing activity. NSC156565 enables bacteriophage Bas34 to overcome Pycsar-mediated resistance, facilitating productive phage infection and replication.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 71335-86-9
- 分子式: C22H17NO4
- 分子量:359.37
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
NSC156565 (11-111 μM; 1 h pretreatment) potently inhibits the Pycsar antiphage defense in Pycsar-expressing E. coli JW5503ΔtolC, enabling >104-fold increased Bas34 phage replication and phage-induced bacterial lysis when used at 111 μM[1].
NSC156565 (111 μM) does not inhibit cCMP production by the PycC cyclase in PycC-expressing E. coli MG1655[1].
NSC156565 (11 μM; 200 min) blocks PycTM-induced cell death in Pycsar-expressing E. coli JW5503ΔtolC, rescuing growth inhibited by exogenous cCMP[1].
NSC156565 (0.01-100 μM; 1 h pretreatment) inhibits the Pycsar antiphage defense in Pycsar-expressing E. coli JW5503ΔtolC in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 71335-86-9
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分子量 359.37
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分子式 C22H17NO4
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SMILES
OC1=C2C(C3=C(C(C2=C(C=C1)NC4=CC=C(C=C4)CCO)=O)C=CC=C3)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NSC156565 関連分類
HY-183556 関連分類
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