RS5517
Based on 1 Customer Validation
RS5517 is a specific PDZ1-domain antagonist of NHERF1 that prevented its ectopic nuclear entry. RS5517 can be used for the research of colorectal cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.79%
- CAS 番号: 2227017-46-9
- 分子式: C23H19ClN2O2
- 分子量:390.86
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
0.1 μM
Compound: 15
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Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
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[PMID: 30996786] |
| DLD-1 | IC50 |
0.5 μM
Compound: 15
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Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of FH535 by MTT assay
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs in presence of FH535 by MTT assay
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[PMID: 30996786] |
| DLD-1 | IC50 |
65 μM
Compound: 15
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Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs by MTT assay
Growth inhibition of human DLD1 cells without NHERF1 expression incubated for 72 hrs by MTT assay
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[PMID: 30996786] |
| LS174T | IC50 |
52 μM
Compound: 15
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Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by absence of doxycycline by MTT assay
Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by absence of doxycycline by MTT assay
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[PMID: 30996786] |
| LS174T | IC50 |
8 μM
Compound: 15
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Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by presence of doxycycline by MTT assay
Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of cell growth incubated for 72 hrs by presence of doxycycline by MTT assay
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[PMID: 30996786] |
| SW480 | IC50 |
0.1 μM
Compound: 15
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Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
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[PMID: 30996786] |
| SW480 | IC50 |
0.9 μM
Compound: 15
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Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
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[PMID: 30996786] |
| SW480 | IC50 |
8 μM
Compound: 15
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Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs by MTT assay
Growth inhibition of human SW480 cells expressing NHERF1 incubated for 72 hrs by MTT assay
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[PMID: 30996786] |
| SW-620 | IC50 |
0.5 μM
Compound: 15
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Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of Ethyl 4-((4-bromophenyl)sulfonamido)benzoate by MTT assay
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[PMID: 30996786] |
| SW-620 | IC50 |
18 μM
Compound: 15
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Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
Growth inhibition of human SW620 cells expressing NHERF1 incubated for 72 hrs in presence of FH53 by MTT assay
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[PMID: 30996786] |
化学情報
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CAS 番号 2227017-46-9
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性状 Solid
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分子量 390.86
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分子式 C23H19ClN2O2
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Color White to light yellow
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SMILES
O=C(C1=C(CC2=CC=CC=C2)C3=C(C=CC(Cl)=C3)N1)NC4=CC=C(CO)C=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Saponaro C, et al. β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy. Oncogene. 2018 Jun;37(24):3301-3316. doi: 10.1038/s41388-018-0170-y. Epub 2018 Mar 19. [Content Brief]
[2]. Capdevielle C, et al. HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53. Neuro Oncol. 2020 Apr 15;22(4):550-562. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
RS5517 関連分類
HY-150269 関連分類
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