Taccalonolide E
Based on 1 Customer Validation
Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis.
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- 純度: 95.14%
- CAS 番号: 134954-57-7
- 分子式: C34H44O12
- 分子量:644.71
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
39.5 μM
Compound: Taccalonolide E
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Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
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[PMID: 23855953] |
| HeLa | IC50 |
39500 nM
Compound: 7
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Antiproliferative activity against human HeLa cells by SRB assay
Antiproliferative activity against human HeLa cells by SRB assay
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[PMID: 24959756] |
| HeLa | IC50 |
644 nM
Compound: 3
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Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay
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[PMID: 21800839] |
Taccalonolide E (5 or 10 μM; 18 h) causes an increased density of cellular microtubules in interphase cells and the formation of thick bundles of microtubules in A-10 cells[1].
Taccalonolide E (1 or 5 μM; 18 h) causes the appearance of abnormal multipolar mitotic spindles in A-10 and HeLa cells[1].
Taccalonolide E (5 μM; 6-24 h) arrests cell cycle at G2-M phase[1].
Taccalonolide E (0.5-5 μM; 18 h) initiates micronucleation in interphase A-10 cells[1].
Taccalonolide E (48 h) inhibits cancer cell proliferation[1].
Taccalonolide E (10 μM; 1 h) causes polymerization of tubulin in MDA-MB-435 cells[1].
Taccalonolide E (5 μM; 4-30 h) initiates Bcl-2 phosphorylation, MAPK activation, and apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-435 cells
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Concentration:5 μM
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Incubation Time:6, 12, 18, or 24 h
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Result:Caused cells to accumulate in the G2-M phase of the cell cycle.
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Cell Line:SK-OV-3, MDA-MB-435, NCI/ADR, 1 A9, PTX 10, PTX 22 and 1A9/A8 cells
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Concentration:
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Incubation Time:48 h
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Result:Inhibited the proliferation with IC50s of 0.99 ± 0.08, 0.78 ± 0.17, 21.1 ± 0.46, 0.34 ± 0.04, 1.64 ± 0.25, 4.01 ± 0.20 and 1.42 ± 0.30 μM against SK-OV-3, MDA-MB-435, NCI/ADR, 1 A9, PTX 10, PTX 22 and 1A9/A8 cells, respectively.
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Cell Line:MDA-MB-435 cells
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Concentration:5 μM
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Incubation Time:4, 6, 12, 24, or 30 h
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Result:Activated ERK1/2 and increased PARP cleavage.
化学情報
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CAS 番号 134954-57-7
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性状 Solid
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分子量 644.71
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分子式 C34H44O12
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Color White to off-white
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SMILES
CC(O[C@H]1[C@]2([H])[C@@]([C@@H](C=C3[C@@]2([C@](O)(C(O3)=O)C)C)C)([H])[C@@]4([C@]1([H])[C@@]5([H])[C@]([C@]6([C@H]([C@]7([H])[C@](O7)([H])C[C@]6([H])C([C@@H]5O)=O)OC(C)=O)C)([H])C[C@@H]4OC(C)=O)C)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Taccalonolide E 関連分類
HY-N11067 関連分類
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