(2R,4R)-APDC
(2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 169209-63-6
- 화학식: C6H10N2O4
- 분자량:174.15
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
group II mGlu receptors |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>100 μM
Compound: 18
|
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
|
[PMID: 15801843] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Adult male Sprague-Dawley rats weighing between 300 and 350 g[2]
-
Dosage:1 nmol/10 μl; 10 nmol/10μl
-
Administration:ICV; daily for 14 days
-
Result:Resulted in decreased BrdU-immunoreactive cells in the DG.
Chemical Information
-
CAS No. 169209-63-6
-
분자량 174.15
-
화학식 C6H10N2O4
-
SMILES
O=C([C@@H]1NC[C@](C(O)=O)(N)C1)O
-
Synonyms
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Folbergrová J, et al. Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats. Brain Res. 2009 Jun 1;1273:144-54. [Content Brief]
[2]. Yao H, et al. 2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. Neuroreport. 2007 Sep 17;18(14):1459-62. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(2R,4R)-APDC Related Classifications
HY-102091 Related Classifications
Powered by Bioz