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Cat. No.: HY-112148

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AKT-IN-2

AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC₅₀ of 5 nM for AKT1.

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CAS No.: 1295514-91-8
화학식: C₂₅H₃₄F₃N₇O
분자량:505.58

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

AKT-IN-2 Chemical Structure

CAS No.: 1295514-91-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC₅₀ of 5 nM for AKT1^[1].

IC₅₀ & Target^[1]

Akt1

5 nM (IC₅₀)

P70S6K

399 nM (IC₅₀)

PKA

84 nM (IC₅₀)

PKCβ2

3.98 μM (IC₅₀)

RSK1

568 nM (IC₅₀)

pGSK3β

92 nM (IC₅₀)

All Akt Isoforms :

In Vitro

AKT-IN-2 (Compound 8) also inhibits P70S6K, PKA, PKCβ2, RSK1, and pGSK3β with IC₅₀s of 0.399, 0.084, 3.98, 0.568, and 0.092 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1295514-91-8
분자량 505.58
화학식 C₂₅H₃₄F₃N₇O
SMILES

O=C1C[C@@H](C)C2=C(N3CCC(C4=NC(CCC(F)(F)F)=CN4CCN5CCCC5)CC3)N=CN=C2N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Parthasarathy S, et al. Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1887-1891. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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AKT-IN-2

Capivasertib

SC79

MK-2206 dihydrochloride

Ipatasertib

Perifosine

AKT inhibitor VIII

GSK-690693

AKT Kinase Inhibitor

Miransertib

Isobavachalcone

Deguelin

Uprosertib

All Akt Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AKT-IN-2

Capivasertib

SC79

MK-2206 dihydrochloride

Ipatasertib

Perifosine

AKT inhibitor VIII

GSK-690693

AKT Kinase Inhibitor

Miransertib

Isobavachalcone

Deguelin

Uprosertib

All Akt Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AKT-IN-2 Related Classifications

HY-112148 Related Classifications