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Cat. No.: HY-19219

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BMS-189664

BMS-189664 is a potent, selective, and orally active reversible inhibitor of a-thrombin, with an IC₅₀ of 0.046 μM. BMS-189664 can be used for arterial and venous thrombosis research.

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CAS No.: 162166-80-5
화학식: C₂₂H₃₄N₆O₄S
분자량:478.61

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BMS-189664 Chemical Structure

CAS No.: 162166-80-5

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

BMS-189664 is a potent, selective, and orally active reversible inhibitor of a-thrombin, with an IC₅₀ of 0.046 μM. BMS-189664 can be used for arterial and venous thrombosis research^[1].

In Vivo

BMS-189664 is efficacious at protecting mice from thrombin-induced lethality^[1].
BMS-189664 (0.2 mg/kg, iv) inhibits arterial thrombosis in cynomolgus monkey models^[1].
BMS-189664 (infused at 9, 25, and 100 mg/kg/min for 1 h to achieve 0.5, 2, and 6 mg/kg) inhibits venous thrombosis in cynomolgus monkey models^[1].
The oral bioavailability of BMS-189664 based on the dose-normalized AUCs after oral and iv dosing was 15 and 17% in dogs and monkeys, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 162166-80-5
분자량 478.61
화학식 C₂₂H₃₄N₆O₄S
SMILES

O=C(N1CCC[C@H]1C(NCC2CCN(C(N)=N)CC2)=O)[C@H](NS(C)(=O)=O)CC3=CC=CC=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Das J, et al. Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. Bioorg Med Chem Lett. 2002 Jan 7;12(1):45-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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