CI 972 anhydrous
CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent.
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- CAS No.: 115787-68-3
- 화학식: C11H12ClN5OS
- 분자량:297.76
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Ki: 0.83 μM (PNP)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLT-4 | IC50 |
3 μM
Compound: 11c
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Compound was tested for the cytotoxic activity against MOLT-4 lymphoblasts
Compound was tested for the cytotoxic activity against MOLT-4 lymphoblasts
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[PMID: 1578487] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 115787-68-3
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분자량 297.76
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화학식 C11H12ClN5OS
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SMILES
O=C1C(NC(N)=C2CC3=CSC=C3)=C2NC(N)=N1.[H]Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Gilbertsen RB, et al. Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor. Adv Exp Med Biol. 1991;309A:41-4. [Content Brief]
[2]. Gilbertsen RB,et al. Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972. Biochem Biophys Res Commun. 1991 Aug 15;178(3):1351-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CI 972 anhydrous Related Classifications
HY-118047 Related Classifications
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