Evariquinone
Evariquinone is an anthraquinone compound isolated from the endophytic fungus Colletotrichum sp. JS-0367 of mulberry. Evariquinone possesses direct antioxidant activity. It inhibits excessive phosphorylation of the JNK, ERK1/2 and p38 MAPK signaling pathways by suppressing ROS and Ca2+, thereby reducing neuronal apoptosis. Evariquinone can be used to study glutamate excitotoxicity-related neurological disorders (such as Alzheimer's disease, Parkinson's disease, cerebral ischemia, etc.).
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- CAS No.: 594860-23-8
- 화학식: C16H12O6
- 분자량:300.26
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Evariquinone (10-100 μM) shows concentration-dependent DPPH radical scavenging activity with an IC50 of 42.2 μM and a maximum activity of 70 ± 1.78% at 100 μM[1].
Evariquinone (12-100 μM; 24 h) provides concentration-dependent neuroprotection against 5 mM glutamate-induced cytotoxicity in HT22 cells, restoring cell viability to near control levels at 50 and 100 μM[1].
Evariquinone (50, 100 μM; 8 h) significantly inhibits 5 mM glutamate-induced intracellular ROS accumulation in HT22 cells[1].
Evariquinone (50, 100 μM; 8 h) significantly blocks 5 mM glutamate-induced intracellular Ca2+ influx in HT22 cells, reducing fluorescence intensity to near control levels at 100 μM[1].
Evariquinone (50, 100 μM; 8 h) significantly inhibits 5 mM glutamate-induced phosphorylation of JNK, ERK1/2, and p38 in HT22 cells[1].
Evariquinone (50, 100 μM; 10 h) strongly attenuates 5 mM glutamate-mediated apoptotic cell death in HT22 cells, reducing the percentage of apoptotic cells to ~18% and ~14%, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:immortalized murine hippocampal HT22 neuronal cells
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Concentration:12-100 μM
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Incubation Time:24 h
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Result:Significantly increased cell viability in a concentration-dependent manner; 12 μM increased cell viability to ~50%, 25 μM to ~80%, 50 μM to ~100%, and 100 μM to ~100% relative to control cells.
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Cell Line:HT22 cells
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Concentration:50, 100 μM
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Incubation Time:8 h
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Result:Significantly reduced glutamate-induced phosphorylation of JNK, ERK1/2, and p38; quantitative analysis showed marked decreases in phosphorylated protein levels relative to the glutamate-only treated group.
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Cell Line:HT22 cells
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Concentration:50, 100 μM
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Incubation Time:10 h
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Result:Significantly reduced the percentage of annexin V-positive apoptotic cells; glutamate treatment increased apoptotic cells to ~60%, while 50 μM reduced this to ~18% and 100 μM to ~14%.
Chemical Information
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CAS No. 594860-23-8
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분자량 300.26
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화학식 C16H12O6
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SMILES
O=C1C2=C(C(C3=CC(O)=C(C(O)=C13)O)=O)C=C(C=C2OC)C
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Structure Classification
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Initial Source
endosymbiotic Emericella variecolor CLB38
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Evariquinone Related Classifications
HY-118817 Related Classifications
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- Evariquinone
- 594860-23-8
- Reactive Oxygen Species (ROS)
- Calcium Channel
- JNK
- ERK
- p38 MAPK
- Apoptosis
- mitogen-activated protein kinase
- reactive oxygen species
- c-Jun N-terminal kinase
- calcium ion
- parkinson’s disease
- extracellular signal-regulated kinase 1/2
- HT22 cells
- apoptotic cell death
- alzheimer’s disease
- p38 mitogen-activated protein kinase
- Inhibitor
- inhibitor
- inhibit