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Sh3pxd2b - SH3 and PX domains 2B Gene

Also Known as TSK4; Tks4; fad49; G431001E03Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 268396

Summary

Enables SH2 domain binding activity and phosphatidylinositol phosphate binding activity. Involved in several processes, including animal organ development; osteoblast fate commitment; and podosome assembly. Located in cytoplasm and podosome. Is expressed in several structures, including branchial arch; central nervous system; heart; jaw; and skeleton. Used to study glaucoma and otitis media. Human ortholog(s) of this gene implicated in Frank-Ter Haar syndrome. Orthologous to human SH3PXD2B (SH3 and PX domains 2B). [provided by Alliance of Genome Resources, Apr 2022]

Sh3pxd2b Products (1)

mRNA	Protein	Name
NM_177364.4	NP_796338.2	SH3 and PX domain-containing protein 2B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH2 domain binding	IDA IDA: Inferred from direct assay	18959745	MGI
enables phosphatidylinositol-3,5-bisphosphate binding	IDA IDA: Inferred from direct assay	18959745	MGI
enables phosphatidylinositol-3-phosphate binding	IMP IMP: Inferred from mutant phenotype	18959745	MGI
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	18959745	MGI
enables phosphatidylinositol-5-phosphate binding	IDA IDA: Inferred from direct assay	18959745	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in adipose tissue development	IMP IMP: Inferred from mutant phenotype	20137777	MGI
involved in bone development	IMP IMP: Inferred from mutant phenotype	20137777	MGI
involved in cranial skeletal system development	IMP IMP: Inferred from mutant phenotype	27711054	MGI
involved in eye development	IMP IMP: Inferred from mutant phenotype	20137777	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	20137777	MGI
involved in osteoblast fate commitment	IMP IMP: Inferred from mutant phenotype	27711054	MGI
involved in podosome assembly	IMP IMP: Inferred from mutant phenotype	19144821	MGI
involved in positive regulation of adipose tissue development	IMP IMP: Inferred from mutant phenotype	27711054	MGI
involved in positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	18959745	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27711054	MGI
involved in positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	27711054	MGI
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	27711054	MGI
involved in regulation of brood size	IMP IMP: Inferred from mutant phenotype	27711054	MGI
involved in skeletal system development	IMP IMP: Inferred from mutant phenotype	20137777	MGI
involved in skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	27711054	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18959745	MGI
located in podosome	IDA IDA: Inferred from direct assay	19144821	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
SH3 and PX domain-containing protein 2B	factor for adipocyte differentiation 49 tyrosine kinase substrate with four SH3 domains

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12843	SH3PXD2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sh3pxd2b	NCBI	NCBI:285590