GPLGIAGQC
GPLGIAGQC is an MMP2-cleavable peptide. In nanoparticle-drug conjugation systems, GPLGIAGQC is cleaved by MMP2 between the glycine and isoleucine residues. After MMP2-mediated hydrolysis of GPLGIAGQC, the Fc fragment is exposed on the surface of nanoparticles.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 1423719-70-3
- 화학식: C34H58N10O11S
- 분자량:814.95
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
The GPLGIAGQC peptide (10-40 nM MMP2; 24 h) acts as an MMP2-cleavable linker in AP-PP-DOX nanoparticles, enabling sustained, MMP2-dependent release of DOX with minimal leakage in MMP2-deficient conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1423719-70-3
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분자량 814.95
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화학식 C34H58N10O11S
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Sequence
Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln-Cys
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Sequence Shortening
GPLGIAGQC
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Wang MZ, et al. A Nano Drug Delivery System Based on Angelica sinensis Polysaccharide for Combination of Chemotherapy and Immunotherapy. Molecules. 2020 Jul 7;25(13):3096. [Content Brief]
[2]. Liu XY, et al. A nano-innate immune system activator for cancer therapy in a 4T1 tumor-bearing mouse model. J Nanobiotechnology. 2022 Jan 29;20(1):54. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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