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Cat. No.: HY-124961

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LSD1-IN-2

LSD1-IN-2 is a LSD1 inhibitor with an IC₅₀ of 0.5 μM. LSD1-IN-2 increases the levels of monomethylated and dimethylated histone H3 lysine 4 (H3K4me1/2) in cells. LSD1-IN-2 reactivates epigenetically silenced tumor suppressor genes. LSD1-IN-2 can be used in the research of colon cancer.

For research use only. We do not sell to patients.

CAS No.: 927019-63-4
Formula: C₁₅H₃₆N₈
Molecular Weight:328.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LSD1-IN-2 Chemical Structure

CAS No.: 927019-63-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

LSD1

0.5 μM (IC₅₀)

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

In Vitro

LSD1-IN-2 (Compound 39) potently inhibits LSD1 with an IC₅₀ of 0.5 μM^[1].
LSD1-IN-2 (0.5-10 μM) induces dose-dependent increases in H3K4me1/2 levels and tumor suppressor gene re-expression in HCT-116 colon cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 927019-63-4
Molecular Weight 328.51
Formula C₁₅H₃₆N₈
SMILES

N(=C(NC)NC)CCCNCCCNCCCN=C(NC)NC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Decarlo D, et al. Oncoepigenomics: making histone lysine methylation count. European journal of medicinal chemistry. 2012 Oct;56:179-94. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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