1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. ML 10302 hydrochloride

ML 10302 hydrochloride 

Cat. No.: HY-14442
Handling Instructions

ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay.

For research use only. We do not sell to patients.

ML 10302 hydrochloride Chemical Structure

ML 10302 hydrochloride Chemical Structure

CAS No. : 186826-17-5

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Description

ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay[1][2].

IC50 & Target[1]

5-HT4 Receptor

4 nM (EC50)

5-HT4 Receptor

1.07 nM (Ki)

5-HT3 Receptor

782 nM (Ki)

In Vitro

ML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ML 10302 hydrochloride (20 mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-weeks old adult male C57BL/6j wild-type mice (23-27 g)[3]
Dosage: 5 mg/kg, 10 mg/kg, 20 mg/kg
Administration: Subcutaneous injection
Result: Significantly increased sAPPα level in the cortex.
Molecular Weight

349.25

Formula

C15H22Cl2N2O3

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
ML 10302 hydrochloride
Cat. No.:
HY-14442
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