ML 10302 hydrochloride
ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay.
For research use only. We do not sell to patients.
- CAS No.: 186826-17-5
- Formula: C15H22Cl2N2O3
- Molecular Weight:349.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
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5-HT4 Receptor 4 nM (EC50) |
5-HT4 Receptor 1.07 nM (Ki) |
5-HT3 Receptor 782 nM (Ki) |
ML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-weeks old adult male C57BL/6j wild-type mice (23-27 g)[3]
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Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg
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Administration:Subcutaneous injection
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Result:Significantly increased sAPPα level in the cortex.
Chemical Information
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CAS No. 186826-17-5
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Molecular Weight 349.25
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Formula C15H22Cl2N2O3
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SMILES
O=C(OCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. D Yang, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997 Feb 14;40(4):608-21. [Content Brief]
[3]. M Cachard-Chastel, et al. 5-HT4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007 Apr; 150(7): 883–892. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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