ML 10302 hydrochloride
ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay.
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- CAS. Nr.: 186826-17-5
- Formel: C15H22Cl2N2O3
- Molecular Weight:349.25
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
5-HT4 Receptor 4 nM (EC50) |
5-HT4 Receptor 1.07 nM (Ki) |
5-HT3 Receptor 782 nM (Ki) |
In Vitro
ML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-weeks old adult male C57BL/6j wild-type mice (23-27 g)[3]
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Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg
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Administration:Subcutaneous injection
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Result:Significantly increased sAPPα level in the cortex.
Chemical Information
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CAS. Nr. 186826-17-5
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Molecular Weight 349.25
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Formel C15H22Cl2N2O3
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SMILES
O=C(OCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC.[H]Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[2]. D Yang, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997 Feb 14;40(4):608-21. [Content Brief]
[3]. M Cachard-Chastel, et al. 5-HT4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007 Apr; 150(7): 883–892. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ML 10302 hydrochloride Related Classifications
HY-14442 Related Classifications
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