ML 10302 hydrochloride

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ML 10302 hydrochloride is a potent and selective 5-HT₄ receptor agonist, with an EC₅₀ of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT₃ receptor in binding assay.

For research use only. We do not sell to patients.

ML 10302 hydrochloride Chemical Structure

CAS No. : 186826-17-5

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Other Forms of ML 10302 hydrochloride:

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

5-HT₄ Receptor

4 nM (EC₅₀)

5-HT₄ Receptor

1.07 nM (Ki)

5-HT₃ Receptor

782 nM (Ki)

In Vitro

ML 10302 hydrochloride shows K_is of 1.07 nM and 782 nM for 5-HT₄ receptor and 5-HT₃ receptor, respectively, in binding assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ML 10302 hydrochloride (20 mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-weeks old adult male C57BL/6j wild-type mice (23-27 g)^[3]
Dosage:	5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:	Subcutaneous injection
Result:	Significantly increased sAPPα level in the cortex.

Molecular Weight

349.25

Formula

C₁₅H₂₂Cl₂N₂O₃

CAS No.

186826-17-5

SMILES

O=C(OCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Langlois, M., et al. Design of a potent 5-HT4 receptor agonist with nanomolar affinity. Bioorganic & Medicinal Chemistry Letters. 1994. 4(12), 1433–1436.

[2]. D Yang, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997 Feb 14;40(4):608-21. [Content Brief]

[3]. M Cachard-Chastel, et al. 5-HT4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007 Apr; 150(7): 883–892. [Content Brief]