186826-17-5
186826-17-5
Chemical Structure
ML 10302 hydrochloride
- CAS No.: 186826-17-5
- Formula:C15H22Cl2N2O3
- Molecular Weight:349.25
IUPAC Name: 2-(piperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
InChIKey: HBLRTSYSGOFQCK-UHFFFAOYSA-N
SMILES: O=C(OCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC.[H]Cl
Biological Activity: ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay[1][2].
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ML 10302 hydrochloride | ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay. | |||||||||||||||||||||
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References
- [1]. Langlois, M., et al. Design of a potent 5-HT4 receptor agonist with nanomolar affinity. Bioorganic & Medicinal Chemistry Letters. 1994. 4(12), 1433–1436.
- [2]. D Yang, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997 Feb 14;40(4):608-21. [Content Brief]
Keywords
