Compounds from the roots and rhizomes of Valeriana amurensis protect against neurotoxicity in PC12 cells

  • Molecules. 2012 Dec 18;17(12):15013-21. doi: 10.3390/molecules171215013.
Qiuhong Wang  1 ,  Changfu Wang ,  Yueming Zuo ,  Zhibin Wang ,  Bingyou Yang ,  Haixue Kuang
Affiliations
  • 1. Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, No. 24 HePing Road, XiangFang District, Harbin 150040, China. [email protected]
PMID: 23250029 DOI: 10.3390/molecules171215013
Abstract

Three new germacrane-type sesquiterpenoids, heishuixiecaoline A-C (compounds 1-3), were isolated along with ten known compounds 4-13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer's disease (AD). The structures of 1-3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1-13 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ(25-25)), respectively. As a result, germacrane-type sesquiterpenoids 1-4 and Lignans 5-7 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD.

Products