1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Radezolid

Radezolid (Synonyms: RX-1741)

Cat. No.: HY-14800 Purity: 99.27%
Handling Instructions

Radezolid (RX-1741) is a oxazolidinone antibiotic. Radezolid is active against Staphylococcus, Chlamydia, and Legionella species, and remains active against Linezolid-resistant strains.

For research use only. We do not sell to patients.

Radezolid Chemical Structure

Radezolid Chemical Structure

CAS No. : 869884-78-6

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 224 In-stock
Estimated Time of Arrival: December 31
5 mg USD 204 In-stock
Estimated Time of Arrival: December 31
10 mg USD 343 In-stock
Estimated Time of Arrival: December 31
50 mg USD 862 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 9 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Radezolid purchased from MCE. Usage Cited in: Br J Cancer. 2021 Mar 24.

    Radezolid (10-50μM; 48 hours) treatment significantly reduces the expression of YAP1 target genes (both at protein and mRNA level) in H357CisR and SCC-9 CisR cells.
    • Biological Activity

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    • References

    • Customer Review

    Description

    Radezolid (RX-1741) is a oxazolidinone antibiotic. Radezolid is active against Staphylococcus, Chlamydia, and Legionella species, and remains active against Linezolid-resistant strains[1][2].

    In Vitro

    Radezolid MICs are systematically equal to or lower (up to 3 log2 dilutions) than those of linezolid for all linezolid-susceptible strains, with an 8-fold difference for the linezolid-resistant strains. Radezolid shows a greater potency than linezolid, independent of the bacteria tested, when concentrations are expressed on a weight (mg/L) basis. Radezolid shows an improved potency compared to that of linezolid when concentrations are expressed on a weight (mg/L) basis[1]. Radezolid and TR-700 perform well against 3-copy G2447T, G2576T, and G2576T/T2571C mutants[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    438.45

    Formula

    C₂₂H₂₃FN₆O₃

    CAS No.

    869884-78-6

    SMILES

    CC(NC[[email protected]]1CN(C2=CC=C(C3=CC=C(CNCC4=CN=NN4)C=C3)C(F)=C2)C(O1)=O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 25 mg/mL (57.02 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2808 mL 11.4038 mL 22.8076 mL
    5 mM 0.4562 mL 2.2808 mL 4.5615 mL
    10 mM 0.2281 mL 1.1404 mL 2.2808 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.70 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.70 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.70 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Cell Assay
    [1]

    Antibiotic accumulation is determined following the general procedure, and the cellular content of [14C]radezolid is assayed in cell lysates by liquid scintillation counting (lowest limit of detection, 0.003 mg/liter; linear response between 0.01 and 0.78 mg/liter; R2=0.999). All cell drug contents are expressed by reference to the total cell protein content and converted into apparent total cell concentrations using a conversion factor of 5 μL per mg of cell protein.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Keywords:

    RadezolidRX-1741RX1741RX 1741BacterialAntibioticInhibitorinhibitorinhibit

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