CXCR2 Protein, Mouse (Cell-Free, His)

CXCR2 protein acts as a receptor for interleukin-8 and induces neutrophil activation through the G protein-mediated phosphatidylinositol-calcium second messenger system. In addition to IL-8, CXCR2 also exhibits high-affinity binding to ligands such as CXCL3, GRO/MGSA, and NAP-2. CXCR2 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived CXCR2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CXCR2 Protein, Mouse (Cell-Free, His) is 359 a.a., with molecular weight of 43.2 kDa.

CXCR2 Protein serves as the receptor for interleukin-8, a potent neutrophil chemotactic factor, and its binding to the receptor leads to the activation of neutrophils. This response is mediated through a G-protein, initiating a phosphatidylinositol-calcium second messenger system. CXCR2 exhibits high-affinity binding not only to IL-8 but also to other ligands, including CXCL3, GRO/MGSA, and NAP-2. The protein interacts directly with IL8 and associates with GNAI2, highlighting its role in intricate signaling pathways involved in the regulation of neutrophil activity and chemotaxis. These interactions emphasize the significance of CXCR2 in mediating immune responses, particularly those related to the recruitment and activation of neutrophils in various physiological and pathological contexts.

Mouse

E. coli Cell-free

N-10*His

P35343 (M1-L359)

12765

MGEFKVDKFNIEDFFSGDLDIFNYSSGMPSILPDAVPCHSENLEINSYAVVVIYVLVTLLSLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLFFALTLPVWAASKVNGWTFGSTLCKIFSYVKEVTFYSSVLLLACISMDRYLAIVHATSTLIQKRHLVKFVCIAMWLLSVILALPILILRNPVKVNLSTLVCYEDVGNNTSRLRVVLRILPQTFGFLVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLVFLLCWLPYNLVLFTDTLMRTKLIKETCERRDDIDKALNATEILGFLHSCLNPIIYAFIGQKFRHGLLKIMATYGLVSKEFLAKEGRPSFVSSSSANTSTTL

43.2 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.