TRIM3 Protein, Human (GST)
TRIM3 protein is an E3 ubiquitin ligase that regulates neuronal plasticity, learning, and memory. TRIM3 Protein, Human (GST) is the recombinant human-derived TRIM3 protein, expressed by E. coli , with N-GST labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
TRIM3 protein is an E3 ubiquitin ligase that regulates neuronal plasticity, learning, and memory. TRIM3 Protein, Human (GST) is the recombinant human-derived TRIM3 protein, expressed by E. coli , with N-GST labeled tag.
TRIM3, an E3 ubiquitin ligase, assumes crucial roles in neuronal functions, orchestrating the regulation of neuronal plasticity, learning, and memory. Beyond its neuronal involvement, TRIM3 extends its influence to various biological processes, including innate immunity and cell cycle regulation. Within neurons, it becomes a key component of the cytoskeleton-associated recycling or transport complex, exerting its regulatory role by polyubiquitinating gamma-actin and thereby influencing neuronal plasticity. Additionally, TRIM3 ubiquitinates the postsynaptic scaffold GKAP, contributing to synaptic remodeling and modulation of dendritic spine morphology. It positively regulates the motility of the microtubule-dependent motor protein KIF21B. Moreover, TRIM3, through its RING-dependent E3 ligase activity, induces growth arrest and ubiquitinates CDKN1A. In the realm of innate immunity, it plays a positive regulatory role in TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3, subsequently facilitating the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-GST
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Accession
O75382 (A2-Q744)
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Gene ID10612
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Molecular Construction
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N-term
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GST
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TRIM3 (A2-Q744)
Accession # O75382 -
C-term
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Protein Length
Full Length
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Synonyms
TRIM3; BERP; RNF22; RNF97; Tripartite motif-containing protein 3; EC 2.3.2.27; Brain-expressed RING finger protein; RING finger protein 22; RING finger protein 97; Alternative Protein TRIM3; Brain Expressed Ring Finger; Tripartite Motif Containing 3; Trip
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AA Sequence
AKREDSPGPEVQPMDKQFLVCSICLDRYQCPKVLPCLHTFCERCLQNYIPAQSLTLSCPVCRQTSILPEQGVSALQNNFFISSLMEAMQQAPDGAHDPEDPHPLSVVAGRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVVEQHKAALQRQLEAVRGRLPQLSAAIALVGGISQQLQERKAEALAQISAAFEDLEQALQQRKQALVSDLETICGAKQKVLQSQLDTLRQGQEHIGSSCSFAEQALRLGSAPEVLLVRKHMRERLAALAAQAFPERPHENAQLELVLEVDGLRRSVLNLGALLTTSATAHETVATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELRAEITGPDGTRLPVPVVDHKNGTYELVYTARTEGELLLSVLLYGQPVRGSPFRVRALRPGDLPPSPDDVKRRVKSPGGPGSHVRQKAVRRPSSMYSTGGKRKDNPIEDELVFRVGSRGREKGEFTNLQGVSAASSGRIVVADSNNQCIQVFSNEGQFKFRFGVRGRSPGQLQRPTGVAVDTNGDIIVADYDNRWVSIFSPEGKFKTKIGAGRLMGPKGVAVDRNGHIIVVDNKSCCVFTFQPNGKLVGRFGGRGATDRHFAGPHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFLSYINTSAEPLYGPQGLALTSDGHVVVADAGNHCFKAYRYLQ
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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