2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. S 15931

S 15931 is a 5-HT1A receptor inhibitor. S 15931 inhibits the late-phase hindpaw licking response induced by formalin and the abdominal writhing response induced by acetic acid in Mus musculus. S 15931 abolishes the spontaneous tail-flick response induced by 8-OH-DPAT in Rattus norvegicus and potentiates the analgesic effect of morphine. S 15931 is applicable for pain-related research.

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S 15931

S 15931 Chemical Structure

CAS No. : 153607-45-5

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Description

S 15931 is a 5-HT1A receptor inhibitor. S 15931 inhibits the late-phase hindpaw licking response induced by formalin and the abdominal writhing response induced by acetic acid in Mus musculus. S 15931 abolishes the spontaneous tail-flick response induced by 8-OH-DPAT in Rattus norvegicus and potentiates the analgesic effect of morphine. S 15931 is applicable for pain-related research[1].

In Vivo

S 15931 (40 mg/kg; s.c.; single administration; 30 min before testing) exerts stronger inhibitory efficacy on the late phase than the early phase of formalin-induced licking response in male NMRI mice[1].
S 15931 (40 mg/kg; s.c.; single administration; 30 min before testing) inhibits acetic acid-induced writhing response in male NMRI mice[1].
S 15931 (40 mg/kg; s.c.; single administration; 30 min before testing) induces rotarod ataxia in male NMRI mice[1].
S 15931 (40 mg/kg; s.c.; single administration; administered 20 minutes prior to 8-OH-DPAT treatment) potently inhibits the spontaneous tail-flick response induced by 8-OH-DPAT (HY-112061) in male Wistar rats[1].
S 15931 (0-10.0 mg/kg; s.c.; single administration; 60 min before testing) does not alter vocalization threshold on its own, but it enhances the analgesic effect of morphine in a dose-dependent manner in the electrically stimulated tail vocalization test in male Wistar rats, with a significant effect observed at doses ≥0.63 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NMRI (male, 20-25 g, formalin-induced hindpaw licking model)[1]
Dosage: 40.0 mg/kg
Administration: s.c.; single dose; 30 minutes pre-test
Result: Achieved an ID50 of 1.2 mg/kg for inhibition of the early phase of formalin-induced licking, producing a 95% maximum observed effect at 40.0 mg/kg.
Achieved an ID50 of 0.3 mg/kg for inhibition of the late phase of formalin-induced licking, producing a 99% maximum observed effect at 40.0 mg/kg.
Animal Model: NMRI (male, 20-25 g, acetic acid-induced abdominal writhing model)[1]
Dosage: 40.0 mg/kg
Administration: s.c.; single dose; 30 minutes pre-test
Result: Achieved an ID50 of 10.4 mg/kg for inhibition of acetic acid-induced writhing, producing a 93% maximum observed effect at 40.0 mg/kg.
Animal Model: NMRI (male, 20-25 g, rotarod ataxia model)[1]
Dosage: 40.0 mg/kg
Administration: s.c.; single dose; 30 minutes pre-test
Result: Achieved an ID50 of 21.3 mg/kg for induction of rotarod ataxia, producing a 90% maximum observed effect at 40.0 mg/kg.
Animal Model: Wistar (male, 200-250 g, 8-OH-DPAT-induced spontaneous tail-flicks model)[1]
Dosage: 40.0 mg/kg
Administration: s.c.; single dose; 20 minutes pre-8-OH-DPAT
Result: Achieved an ID50 of 0.7 mg/kg for inhibition of 8-OH-DPAT-induced spontaneous tail-flicks, producing a 99% maximum observed effect at 40.0 mg/kg.
Animal Model: Wistar (male, 200-250 g, electrical tail stimulation vocalization model)[1]
Dosage: 0.01, 0.04, 0.16, 0.83, 2.5, 10.0 mg/kg
Administration: s.c.; single dose; 60 minutes pre-test
Result: Did not significantly alter vocalization threshold relative to vehicle when administered alone.
Dose-dependently facilitated morphine's antinociceptive action, with significant potentiation observed at doses of 0.63 mg/kg, 2.5 mg/kg, and 10.0 mg/kg when co-administered with morphine.
Molecular Weight

364.48

Formula

C23H28N2O2
CAS No.
SMILES

C12=CC=CC(N3CCN(CCC4C5=C(CC4)C=CC=C5)CC3)=C1OCCO2
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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S 15931 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S 15931153607-45-5S15931S-159315-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptormale NMRI micemorphineratsantinociceptionacetic acid-induced abdominal writhing8-OH-DPAT-induced spontaneous tail-flicksformalin-induced hindpaw lickingataxia5-HT1A receptormiceInhibitorinhibitorinhibit

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