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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
ASGP-R
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "ASGP-R" in MCE Product Catalog:
Cat. No.: HY-146152
CAS No.: 2052968-88-2
ASGPR modulator-1 (Compound 5TJX) is a macrocycle compound that can be uesd for protein-protein interaction study .
Cat. No.: HY-19272
CAS No.: 185843-61-2
Research Areas:
OGT-719 is a potent, orally active nucleoside analogue that targets the asialoglycoprotein receptor (ASGP-R). OGT-719 inhibits growth of metastatic colorectal tumors in the liver of nude mice. OGT-719 can be used for primary hepatocellular carcinoma and colorectal liver metastases research .
Cat. No.: HY-RS01085
Target:
Research Areas:
ASGR1 Human Pre-designed siRNA Set A contains three designed siRNAs for ASGR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-142885
CAS No.: 2378837-56-8
M-MoDE-A (2) is a bifunctional small molecule that mediates the degradation of extracellular proteins through the asialoglycoprotein receptor (ASGPR).
Cat. No.: HY-P705990
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Asialoglycoprotein receptor 1; ASGP-R 1; ASGPR 1; Hepatic lectin 1; HL-1; rHL-1
Cat. No.: HY-112752
CAS No.: 219850-70-1
Cat. No.: HY-P704414
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ASGPR; ASGPR1; ASGR1; Asialoglycoprotein receptor 1; CLEC4H1; Hepatic lectin H1; MHL1
Cat. No.: HY-185590
CAS No.: 3084453-02-8
Research Areas:
tri-GalNAc-phosphoric acid is a specific ligand of ASGPR with cell-specific internalization capability. tri-GalNAc-phosphoric acid can mediate the delivery of conjugated sclerostin aptamers to lysosomes of cells expressing ASGPR. tri-GalNAc-phosphoric acid is applicable to anticancer research .
Cat. No.: HY-180909
Research Areas:
TMU454 is a prototype GalNAc-PROTAC conjugate. TMU454 binds to ASGPR on the membrane of cells, and then is internalized via ASGPR-mediated endocytosis. TMU454 selectively degrades BRD4. TMU454 exhibits anticancer activity against hepatocellular carcinoma .
Cat. No.: HY-P704413
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: rHuASGR1, His; Asialoglycoprotein Receptor 1, ASGR1,
Cat. No.: HY-171342
CAS No.: 2893765-20-1
Target:
Research Areas:
Mal-C2-amide-C10-tri-GalNAc (Compound 1226) is an asialoglycoprotein receptor (ASGPR) binding ligand fragment and a component of lysosome-targeted bifunctional molecules. Mal-C2-amide-C10-tri-GalNAc promotes the sequestration and degradation of extracellular target molecules in lysosomes. Mal-C2-amide-C10-tri-GalNAc is used in the research of autoimmune diseases .
Cat. No.: HY-184926
Target:
LYTACs Asialoglycoprotein Receptor (ASGPR) Monocarboxylate Transporter Mitochondrial Metabolism MMP Cadherin
Research Areas:
PEG9MA10-PAB10-GalMA10 is a CD147 LYTAC degrader. PEG9MA10-PAB10-GalMA10 binds to the asialoglycoprotein receptor (ASGPR) via its galactose methacrylate domain, mediating its uptake by hepatoma cells. PEG9MA10-PAB10-GalMA10 induces lysosome-dependent degradation of CD147, resulting in concurrent loss of associated MCT1 and MCT4. PEG9MA10-PAB10-GalMA10 reduces extracellular lactate levels, increases intracellular lactate accumulation, inhibits glycolytic activity, and enhances mitochondrial respiratory capacity. PEG9MA10-PAB10-GalMA10 decreases the secretion of MMP-2 and MMP-9, and upregulates the expression of E-cadherin. PEG9MA10-PAB10-GalMA10 exhibits anti-tumor efficacy in hepatoma models. PEG9MA10-PAB10-GalMA10 can be used for research on liver cancer (hepatocellular carcinoma) .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
