1 Result for "

11028-00-5

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1 Results for "11028-00-5" in MCE Product Catalog:

Bacoside A
Bacoside A
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Cat. No.: HY-N1989
CAS No.: 11028-00-5
Category:  

Triterpenes Terpenoids Metabolic Disease Scrophulariaceae Plants Disease Research Fields Bacopa monnieri (Linn.) Wettst.

Target:  

Na+/K+ ATPase CaMK Apoptosis Cholinesterase (ChE) NO Synthase NF-κB

Bacoside A is an orally active, blood-brain barrier-permeable triterpenoid saponin that modulates the activities of ATPases, AChE, CaMK2A and iNOS. Derived from Bacopa monniera. Bacoside A exerts significant antioxidant, anti-inflammatory and anti-apoptotic effects by maintaining ion balance, scavenging reactive oxygen species, stabilizing cell membranes, and regulating the expression of NF-κB and apoptosis-related proteins. Bacoside A counteracts morphine-induced reductions in Na +/K +-ATPase, Ca 2+-ATPase and Mg 2+-ATPase activities, increases mitochondrial membrane potential, and decreases intracellular reactive oxygen species levels. Bacoside A specifically binds to calcium/calmodulin-dependent protein kinase IIA to trigger endoplasmic reticulum calcium release. Bacoside A exhibits non-apoptotic cytotoxicity against glioblastoma cells while protecting normal nerve cells from stress-induced damage. Bacoside A is applicable to the research of Parkinson's disease and glioblastoma multiforme .
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