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19908-48-6

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "19908-48-6" in MCE Product Catalog:

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Maackiain
Maackiain
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Cat. No.: HY-N0381
CAS No.: 19908-48-6
Synonyms: DL-​Maackiain
Category:  

Infection Natural Products other families Monophenols Phenols Plants Disease Research Fields

Target:  

Keap1-Nrf2 p38 MAPK NOD-like Receptor (NLR) NF-κB mTOR Monoamine Oxidase Nuclear Factor of activated T Cells (NFAT) PKC Apoptosis Pyroptosis Autophagy Dengue Virus

Maackiain (DL-Maackiain) is an orally active multi-target inhibitor with anti-tumor activity and neuroprotective effects. Maackiain activates the AMPK, NLRP3 and Nrf2/HO-1 pathways, and inhibits key targets such as NF-κB, mTOR, MAO-B, NFATc1 and PKCδ, thereby precisely regulating processes including apoptosis, autophagy and pyroptosis. Maackiain also effectively inhibits microglial activation, osteoclast formation, and proliferation and invasion of tumor cells, and protects dopaminergic neurons from damage. Maackiain is applicable to the research of various diseases such as Alzheimer's disease, osteoporosis, sepsis and dengue fever 。
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