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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
89 Results for "
1C3
" in MedChemExpress (MCE) Product Catalog:
Products (89)
89 Results for "1C3" in MCE Product Catalog:
18
8
8 Cited Publications
Cat. No.: HY-P7999
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PPARG; PPARG5; Peroxisome Proliferator Activated Receptor Gamma; Peroxisome Proliferator-Activated Receptor-Gamma Splicing; NR1C3; Peroxisome Proliferative Activated Receptor, Gamma; Peroxisome Proliferator-Activated Receptor Gamma; Peroxisome Proliferato
Species:
Human
Source:
E. coli
3
3 Cited Publications
Cat. No.: HY-19903
CAS No.: 1126084-37-4
Research Areas:
ASP-9521 is a potent, selective and orally available AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3.
3
3 Cited Publications
Research Areas:
S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells .
2
2 Cited Publications
Cat. No.: HY-P1345A
Target:
Research Areas:
1
1 Cited Publications
Research Areas:
AKR1C3-IN-1 is a potent, highly selective inhibitor of AKR1C3, with an IC50 of 13 nM.
1
Target:
Research Areas:
(±)-Naproxen ((Rac)-Naproxen) is the racemate of Naproxen (HY-15030), consisting of R- and S-enantiomers. (±)-Naproxen binds to AKR1C3, which preferentially recognizes the R-enantiomer from the racemic mixture. It is used for AKR1C3 stereoselective ligand recognition and studies on NSAID binding mechanisms .
1
1
1 Cited Publications
Cat. No.: HY-P7604
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AKR1C3; Aldo-Keto Reductase Family 1, Member C3 (3-Alpha Hydroxysteroid Dehydrogenase, Type II), Isoform CRA_a; Prev. HSD17B5; Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase; PGFS; Type IIb 3-Alpha Hydroxysteroid Dehydrogenase; Prostaglandin F Synthase; 3-Alpha-Hydroxysteroid Dehydrogenase Type 2; KIAA0119; 17-Beta-Hydroxysteroid Dehydrogenase Type 5; HAKRB; Hydroxysteroid (17-Beta) Dehydrogenase 5; DDX; Dihydrodiol Dehydrogenase Type I; 3-Alpha Hydroxysteroid Dehydrogenase, Type II; Indanol Dehydrogenase; Testosterone 17-Beta-Dehydrogenase 5; 3-Alpha-HSD Type 2; Chlordecone Reductase Homolog HAKRb; 17-Beta-HSD 5; Dihydrodiol Dehydrogenase X; HluPGFS; Dihydrodiol Dehydrogenase 3; HAKRe; 3-Alpha-HSD Type II, Brain; DD-3; HA1753; DDH1; DD3; Aldo-Keto Reductase Family 1 Member C3; Aldo-Keto Reductase Family 1, Member C3 (3-Alpha Hydroxysteroid Dehydrogenase, Type II)
Species:
Human
Source:
HEK293
Synonyms: OBI-3424; TH-3424; (R)-AST-3424
Research Areas:
(R)-Odafosfamide (OBI-3424) is a proagent that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. (R)-Odafosfamide can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research .
Cat. No.: HY-N10361
CAS No.: 53755-58-1
Category:
Research Areas:
AKR1C3-IN-4 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 0.56 μM. AKR1C3-IN-4 has the potential for castrate resistant prostate cancer (CRPC) research .
Research Areas:
S19-1035 is a highly potent and specific aldo-keto reductase 1C3 (AKR1C3) inhibitor. S19-1035 inhibits AKR1C3 with an IC50 value of 3.04 nM. S19-1035 can be used for the research of tumor .
Target:
Research Areas:
Obafistat is a potent aldo-keto reductase AKR1C3 inhibitor with an IC50 of 1.2 nM for human AKR1C3 (patent WO2017202817A1, example 4) .
Research Areas:
AKR1C3-IN-9 is a selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3) with an IC50 value of 8.92 nM. AKR1C3-IN-9 significantly reverses the Doxorubicin (HY-15142A) (DOX) resistance in a resistant breast cancer cell line .
Cat. No.: HY-149040
CAS No.: 2097713-69-2
Synonyms: (S)-OBI-3424; (S)-TH-3424; AST-3424
Research Areas:
Odafosfamide ((S)-OBI-3424) is a highly selective prodrug bis-alkylating agent activated by aldehyde-keto reductase 1C3 (AKR1C3(). Odafosfamide is highly cytotoxic to cell lines with high AKR1C3 expression. Odafosfamide exhibits antitumor activity in a variety of tumors with high AKR1C3 expression (such as liver cancer, non-small cell lung cancer, and leukemia). Odafosfamide can be used in cancer research .
Cat. No.: HY-116170
CAS No.: 1548116-54-6
SN34037 is a specific inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188) with the ability to inhibit the cytotoxic activity of PR-104A. SN34037-sensitive coumberone reduction provides a rapid and specific assay for AKR1C3 activity. SN34037 inhibits the aerobic cytotoxicity of PR-104A in TF1 erythroleukemia cells with high AKR1C3 expression, but not in Nalm6 pre-B acute lymphoblastic leukemia cells with low AKR1C3 expression .
Cat. No.: HY-D1342
CAS No.: 878019-53-5
Research Areas:
Coumberol is a fluorescent substrate of AKR1C3 protein. Coumberol can be used for the research of AKR1C3 .
Cat. No.: HY-172314
CAS No.: 2377718-85-7
Research Areas:
ACHM-025 is a prodrug, which is selectively activated by AKR1C3 to a nitrogen mustard DNA alkylating agent. ACHM-025 can be used for the research of cancer, such as leukemia .
Cat. No.: HY-42429
CAS No.: 1997304-12-7
Research Areas:
CPI-203-PEG1-C3-O-COOH is a conjugate of the BRD4 ligand (HY-78695) and the linker (HY-42427). CPI-203-PEG1-C3-O-COOH can be used for synthesizing PROTAC BRD4 degrader ARV-771 (HY-100972) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
