2924824-43-9
2924824-43-9
Chemical Structure
AKR1C3-IN-9
- CAS No.: 2924824-43-9
- Formula:C20H20N2O4
- Molecular Weight:352.38
IUPAC Name: 2-oxo-2-(4-(pyridin-2-yl)piperazin-1-yl)ethyl 2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetate
InChIKey: JUPXIAWRJFYWOF-UHFFFAOYSA-N
SMILES: COC1=CC=CC=C1NC(C2=CC=CC=C2OCC3=C(ON=C3C)C)=O
Biological Activity: AKR1C3-IN-9 is a selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3) with an IC50 value of 8.92 nM. AKR1C3-IN-9 significantly reverses the Doxorubicin (HY-15142A) (DOX) resistance in a resistant breast cancer cell line[1].
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AKR1C3-IN-9 | 99.77% | AKR1C3-IN-9 is a selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3) with an IC50 value of 8.92 nM. AKR1C3-IN-9 significantly reverses the Doxorubicin (HY-15142A) (DOX) resistance in a resistant breast cancer cell line. | ||||||||||||||||||||
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