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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
78 Results for "
4.13
" in MedChemExpress (MCE) Product Catalog:
Products (78)
78 Results for "4.13" in MCE Product Catalog:
81
81 Publications Verification
Cat. No.: HY-16562
CAS No.: 97682-44-5
Synonyms: (+)-Irinotecan; CPT-11; VAL-413free base
Target:
Research Areas:
Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .
81
81 Publications Verification
Cat. No.: HY-16562A
CAS No.: 100286-90-6
Synonyms: (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; VAL-413
Category:
Alkaloids Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields Cancer
Target:
7
7 Cited Publications
Cat. No.: HY-N6771
CAS No.: 18172-33-3
7
XL413 is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC50 of 3.4 nM, and also shows potent effect with IC50s of 215, 42 nM on CK2, PIM1, respectively, and an EC50 of 118 nM on pMCM.
7
7 Cited Publications
Synonyms: BMS-863233 monohydrochloride
XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC50 of 3.4 nM, and also shows potent effect with IC50s of 215, 42 nM on CK2, PIM1, respectively, and an EC50 of 118 nM on pMCM.
6
6 Cited Publications
Target:
Research Areas:
DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM) .
6
6 Cited Publications
Cat. No.: HY-13979A
CAS No.: 1780303-76-5
Target:
Research Areas:
DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC50 of 105 nM; 4-fold less potent for DDR2 (IC50 = 413 nM) .
1
Target:
Research Areas:
Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism [4] .
Synonyms: KT-413
Research Areas:
Zomiradomide (KT-413) is an orally active IRAK4 PROTAC degrader with a DC50 of 6 nM. Zomiradomide inhibits the NF-κB signaling pathway, while its molecular glue function mediates the degradation of Ikaros and Aiolos (with a DC50 of 1 nM for both), activates the IFN-I signaling pathway, and selectively degrades IMiD substrates. Zomiradomide inhibits cancer cell proliferation and tumor growth. Zomiradomide can be used in research related to B-cell non-Hodgkin's lymphoma and diffuse large B-cell lymphoma .
Synonyms: GSK961081; TD-5959
Target:
Research Areas:
Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively.
Cat. No.: HY-W750796
CAS No.: 286367-75-7
Synonyms: Butanoic acid-13C4 sodium
Cat. No.: HY-N0830S
CAS No.: 287100-89-4
Cat. No.: HY-100807S2
Cat. No.: HY-111781
CAS No.: 2155853-43-1
Synonyms: WS-413
Civorebrutinib (WS-413) is a selective, orally active BTK and TEC inhibitor with an IC50 of <100 nM for both targets. Civorebrutinib inhibits B cell activation. Civorebrutinib significantly suppresses the in vivo growth of diffuse large B-cell lymphoma cells. Civorebrutinib can be used for the research of diffuse large B-cell lymphoma .
Cat. No.: HY-W035051
CAS No.: 39050-26-5
Cat. No.: HY-N15387
CAS No.: 1094030-09-7
Category:
Target:
Cat. No.: HY-N0473S5
CAS No.: 81201-90-3
Cat. No.: HY-107494
CAS No.: 71748-58-8
Synonyms: 4-Keto 13-cis-retinoic acid; 4-Oxoisotretinoin; Ro 22-6595
Target:
Research Areas:
13-cis-4-Oxoretinoic acid (4-Keto 13-cis-retinoic acid) is a metabolite of vitamin A in human plasma .
Cat. No.: HY-15260C
CAS No.: 1169562-71-3
Synonyms: BMS-863233 hydrochloride
XL413 (BMS-863233) hydrochloride is an orally active and selective CDC7 inhibitor (IC50=3.4 nM). XL413 hydrochloride has favorable pharmacokinetic profiles and significantly inhibits tumor growth in rodent models. XL413 hydrochloride can be used in cancer research .
Cat. No.: HY-B0152S3
Synonyms: 6-Aminopurine-13C5; Vitamin B4-13C5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
