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4.13

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (2) Aldehyde Dehydrogenase (ALDH) (1) Amino Acid Derivatives (1) Amyloid-β (1) Apoptosis (9) Autophagy (6) Bacterial (1) Biochemical Assay Reagents (1) Btk (1) Calcium Channel (1) Carbonic Anhydrase (1) CDK (3) Discoidin Domain Receptor (2) DNA/RNA Synthesis (6) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (1) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (19) FGFR (1) Fluorescent Dye (1) GABA Receptor (1) HDAC (2) HSP (2) IFNAR (1) iGluR (1) IRAK (1) Isotope-Labeled Compounds (28) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (1) LXR (1) mAChR (2) MDM-2/p53 (1) MicroRNA (1) Microtubule/Tubulin (2) MMP (1) MOFs (1) Neprilysin (1) NF-κB (1) NO Synthase (1) PI3K (1) PKC (1) Progesterone Receptor (1) PROTAC Linkers (3) PROTACs (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (2) Reference Standards (4) RSV (1) SARS-CoV (1) Tau Protein (1) Thyroid Hormone Receptor (1) Topoisomerase (6) TSH Receptor (1)
By Research Areas:	Cancer (39) Cardiovascular Disease (4) Endocrinology (5) Infection (7) Inflammation/Immunology (8) Metabolic Disease (7) Neurological Disease (8)
Click Chemistry:	PROTAC Synthesis (1) Azide (2) Alkynes (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16562

Irinotecan Maximum Cited Publications 75 Publications Verification (+)-Irinotecan; CPT-11; VAL-413free base	Topoisomerase Autophagy	Neurological Disease Cancer
Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-16562A

Irinotecan hydrochloride 70+ Cited Publications (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; VAL-413	Topoisomerase Autophagy	Cancer
Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-N6771

Cyclopiazonic acid 5+ Cited Publications	Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV	Infection
Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B ^[1][4][5].

HY-13979

DDR1-IN-1 5 Publications Verification	Discoidin Domain Receptor	Cancer
DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC₅₀ of 105 nM; 4-fold less potent for DDR2 (IC₅₀ = 413 nM) .

HY-153368

Zomiradomide KT-413	PROTACs IRAK NF-κB IFNAR	Cancer
Zomiradomide is an orally active PROTAC degrader for IRAK4 (DC₅₀=6 nM), thereby inhibiting the NF-κB signaling pathway. Zomiradomide acts also as a molecular glue, recruiting Ikaros and Aiolos, and mediating their degradation (DC₅₀ for Ikaros is 1 nM), thereby activating the type I IFN signaling pathway . (Pink: target protein ligand PROTAC IRAK4 ligand-5 (HY-168311), Blue: E3 ligase ligand Thalidomide-4-Br (HY-W039116), Black: linker (HY-168313))

HY-107916

Thyrotropin 1 Publications Verification TSH; Pretiron	TSH Receptor PKC Apoptosis	Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism ^[4] .

HY-15260

XL413 5+ Cited Publications BMS-863233	CDK	Cancer
XL413 is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC₅₀ of 3.4 nM, and also shows potent effect with IC₅₀s of 215, 42 nM on CK2, PIM1, respectively, and an EC₅₀ of 118 nM on pMCM.

HY-15260A

XL413 monohydrochloride 5+ Cited Publications BMS-863233 monohydrochloride	CDK	Cancer
XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC₅₀ of 3.4 nM, and also shows potent effect with IC₅₀s of 215, 42 nM on CK2, PIM1, respectively, and an EC₅₀ of 118 nM on pMCM.

HY-12980

Batefenterol GSK961081; TD-5959	Adrenergic Receptor mAChR	Inflammation/Immunology Endocrinology
Batefenterol (GSK961081;TD-5959) is a novel muscarinic receptor antagonist and β₂-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ₂-adrenoceptor with K_i values of 1.4, 1.3 and 3.7 nM, respectively.

HY-W750796

Butyric acid-13C4 sodium Butanoic acid-13C4 sodium	Isotope-Labeled Compounds Endogenous Metabolite
Butyric acid-13C4 sodium (Butanoic acid-13C4 sodium) is a stable isotope labeled compound with the activity of promoting cell proliferation and regulating gene expression. Butyric acid-13C4 sodium can be used in metabolic research and compound development to help scientists gain a deeper understanding of the role of short-chain fatty acids in organisms. Butyric acid-13C4 sodium also plays an important role in nutrition and intestinal health research, especially in the regulation of probiotic function and intestinal microbiota.

HY-N0830S

*Palmitic acid-1,2,3,4-13C4*	Isotope-Labeled Compounds HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid-1,2,3,4- ¹³C₄ is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .

HY-100807S2

Quinolinic acid-13C4,15N	Isotope-Labeled Compounds iGluR Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Apoptosis	Neurological Disease Inflammation/Immunology
Quinolinic acid-13C4, 15N is an isotopic labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.

HY-111781

Civorebrutinib WS-413	Btk	Cancer
Civorebrutinib (WS-413) is a selective, orally active BTK and TEC inhibitor with an IC₅₀ of <100 nM for both targets. Civorebrutinib inhibits B cell activation. Civorebrutinib significantly suppresses the in vivo growth of diffuse large B-cell lymphoma cells. Civorebrutinib can be used for the research of diffuse large B-cell lymphoma .

HY-W035051

TSPP tetrasodium	MOFs Fluorescent Dye	Infection Cancer
TSPP tetrasodium is a photosensitizer that has shown impressive effects in in vivo regression of cancer and microorganism infections (Ex: 413 nm, Em: 640 nm) .

HY-13979A

DDR1-IN-1 dihydrochloride 5 Publications Verification	Discoidin Domain Receptor	Cancer
DDR1-IN-1 dihydrochloride is a potent and selective DDR1 receptor tyrosine kinase inhibitor with an IC₅₀ of 105 nM; 4-fold less potent for DDR2 (IC₅₀ = 413 nM) .

HY-N0473S5

*L-Tyrosine-4-13C*	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
L-Tyrosine-4- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N15387

Hericenone J	Drug Derivative	Cancer
Hericenone J (Compound 6) is an aromatic compound with anticancer activity, which is found in Hericium erinaceum. Hericenone J is cytotoxic and can significantly reduce the viability of HL-60 human acute promyelocytic leukemia cells with an IC₅₀ value of 4.13 μM. Hericenone J is promising for research of leukemia .

HY-107494

13-cis-4-Oxoretinoic acid 4-Keto 13-cis-retinoic acid; 4-Oxoisotretinoin; Ro 22-6595	Endogenous Metabolite	Others
13-cis-4-Oxoretinoic acid (4-Keto 13-cis-retinoic acid) is a metabolite of vitamin A in human plasma .

HY-15260C

XL413 hydrochloride BMS-863233 hydrochloride	CDK	Cancer
XL413 (BMS-863233) hydrochloride is an orally active and selective CDC7 inhibitor (IC₅₀=3.4 nM). XL413 hydrochloride has favorable pharmacokinetic profiles and significantly inhibits tumor growth in rodent models. XL413 hydrochloride can be used in cancer research .

HY-B0152S3

Adenine-13C5 6-Aminopurine-¹³C₅; Vitamin B4-¹³C₅	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite	Cancer
Adenine- ¹³C₅ (6-Aminopurine- ¹³C₅; Vitamin B4- ¹³C₅) is ¹³C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

HY-15843

MIR96-IN-1	MicroRNA Apoptosis	Cancer
MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with K_ds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively . MIR96-IN-1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-N7092S5

*D-Fructose-4-13C* D(-)-Fructose-4-¹³C	Isotope-Labeled Compounds Endogenous Metabolite	Others
D-Fructose-4- ¹³C is the ¹³C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants .

HY-N0666S6

*L-Aspartic acid-1,4-13C2*	Endogenous Metabolite	Inflammation/Immunology
L-Aspartic acid-1,4- ¹³C₂ is the ¹³C-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-W127841

*Citric acid-2,4-13C2*	Isotope-Labeled Compounds Apoptosis Endogenous Metabolite Bacterial	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Citric acid-2,4- ¹³C₂ is the ¹³C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .

HY-B0389S11

*D-Glucose-4-13C* Glucose-4-¹³C; D-(+)-Glucose-4-¹³C; Dextrose-4-¹³C	Endogenous Metabolite	Metabolic Disease
D-Glucose-4- ¹³C is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-W953766

CRBN ligand-413	Ligands for E3 Ligase	Cancer
CRBN ligand-413 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-413 can be linked to a target protein ligand via a linker to form a PROTAC.

HY-107494R

13-cis-4-Oxoretinoic acid (Standard) 4-Keto 13-cis-retinoic acid (Standard); 4-Oxoisotretinoin (Standard); Ro 22-6595 (Standard)	Reference Standards Endogenous Metabolite	Others
13-cis-4-Oxoretinoic acid (Standard) is the analytical standard of 13-cis-4-Oxoretinoic acid (HY-107494). This product is intended for research and analytical applications. 13-cis-4-Oxoretinoic acid (4-Keto 13-cis-retinoic acid) is a metabolite of vitamin A in human plasma .

HY-121817

Sulfiram	Aldehyde Dehydrogenase (ALDH) Drug Intermediate Amyloid-β	Infection Neurological Disease
Sulfiram is a very weak aldehyde dehydrogenase (ALDH) inhibitor, with an IC₅₀ value of 413 μM against Saccharomyces cerevisiae ALDH. As a photochemical precursor, Sulfiram undergoes photoconversion to form Disulfiram (HY-B0240), a potent ALDH inhibitor. Sulfiram inhibits the dimerization of the extracellular domain fragment (amino acid residues 230-624) of amyloid precursor protein (APP), alters the monomer-dimer equilibrium, induces conformational changes in the fragment, and enhances the production of sAPPα via α-cleavage of APP. Sulfiram can be used in research related to scabies and Alzheimer's disease .

HY-107810

Methyl 13-cis-4-oxoretinoate	RAR/RXR	Cancer
Methyl 13-cis-4-oxoretinoate (Compound 4b) is a retinoic acid receptors (RARs) agonist. Methyl 13-cis-4-oxoretinoate is promising for research of dermatological diseases (e.g., disorders related to abnormal differentiation of keratinocytes) and cancers .

HY-139959S

(±)12(13)-EpOME-d4	Isotope-Labeled Compounds	Others
(±)12(13)-EpOME-d₄ is the deuterium labeled (±)12(13)-EpOME .

HY-141541

MPT0G413	HDAC Tau Protein	Neurological Disease
MPT0G413 (Compound 6) is a potent, selective, orally active and brain-penetrant HDAC6 inhibitor with an IC₅₀ of 3.92 nM. MPT0G413 decreases not only the level of phosphorylation of tau proteins but also the aggregation of tau proteins. MPT0G413 can ameliorate the impaired learning and memory. MPT0G413 can be used for the research of neurological disease, such as Alzheimer's disease .

HY-146275

LXRβ agonist-3	LXR	Cancer
LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC₅₀ of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC₅₀ of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma .

HY-140346AS

*L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride*	Isotope-Labeled Compounds PROTAC Linkers	Cancer
L-Azidohomoalanine-1,2,3,4- ¹³C₄ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Azidohomoalanine hydrochloride. L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W017163S

7-Methylxanthine-2,4,5,6-13C4, 1,3-15N2 (with variable 15N labeling at N9)	Endogenous Metabolite	Metabolic Disease
7-Methylxanthine-2,4,5,6- ¹³C₄, 1,3- ¹⁵N₂ (with variable ¹⁵N labeling at N₉) is the ¹³C and ¹⁵N labeled 7-Methylxanthine . 7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi .

HY-18341S4

L-Thyroxine-13C6-1 Levothyroxine-¹³C₆-1; T4-¹³C₆-1	Isotope-Labeled Compounds Endogenous Metabolite Thyroid Hormone Receptor	Endocrinology
L-Thyroxine- ¹³C₆-1 (Levothyroxine- ¹³C₆-1; T4- ¹³C₆-1) is a ¹³C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-152146

HDAC-IN-50	Apoptosis FGFR HDAC	Cancer
HDAC-IN-50 is a potent and orally active FGFR and HDAC dual inhibitor with IC₅₀ values of 0.18, 1.2, 0.46, 1.4, 1.3, 1.6, 2.6, 13 nM for FGFR1, FGFR2, FGFR3, FGFR4, HDAC1, HDAC2, HDAC6, HDAC8, respectively. HDAC-IN-50 induces Apoptosis and cell cycle arrest at G0/G1 phase. HDAC-IN-50 decreases the expression of pFGFR1, pERK, pSTAT3. HDAC-IN-50 shows anti-tumor activity .

HY-15661A

*OSI-413* free base** CP 373413	Drug Metabolite	Cancer
OSI-413 (free base) (CP 373413) is a major metabolite of Erlotinib (HY-50896). Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC₅₀ of 2 nM for human EGFR .

HY-146465

Anticancer agent 60	Microtubule/Tubulin	Cancer
Anticancer agent 60 (compound 3h) has antiproliferative activity against human HepG2 cells (IC₅₀ = 4.13 μM) and presents antitumor efficacy in a human HepG2 xenograft mouse model .

HY-116956S3

*D-Erythrose-4-13C*	Isotope-Labeled Compounds	Others
D-Erythrose-4- ¹³C is the ¹³C labeled D-Erythrose .

HY-P3171

*Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13)*	Biochemical Assay Reagents	Others
Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) is a melanotropin cyclic peptide. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) ultraprolongs melanotropic activity in frog and lizard skin model with great agonisim. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) exhibits a complete resistance to tryptic degradation .

HY-N0667S4

*L-Asparagine-4-13C monohydrate* (-)-Asparagine-4-13C monohydrate; Asn-4-13C monohydrate; Asparamide-4-13C monohydrate	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Inflammation/Immunology
L-Asparagine-4- ¹³C monohydrate is the ¹³C-labeled L-Asparagine monohydrate (HY-W017443).L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-168313

2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine	PROTAC Linkers	Others
2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine is the PROTAC linker of KT-413 (HY-153368) and can be used in the synthesis of PROTACs .

HY-168311

PROTAC IRAK4 ligand-5	Ligands for Target Protein for PROTAC	Cancer
PROTAC IRAK4 ligand-5 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC IRAK4 ligand-5 can be utilized for the synthesis of KT-413 (HY-153368) .

HY-159678

4-(1,3-Dioxolan-2-yl)phenethyl methanesulfonate	PROTAC Linkers	Cancer
4-(1,3-Dioxolan-2-yl)phenethyl methanesulfonate is a PROTAC Linker. 4-(1,3-Dioxolan-2-yl)phenethyl methanesulfonate can be used in the synthesis of PROTAC SMARCA2/4-degrader-27 (HY-162834) .

HY-N8583

*6α,16,18-Trihydroxycleroda-3(4),13(14)-dien-15,16-olide*	Others	Others
6α,16,18-Trihydroxycleroda-3(4),13(14)-dien-15,16-olide is a Diterpenoids product that can be isolated from the herbs of Polyalthia cheliensis .

HY-N0537S6

*Xylose-4-13C* D-(+)-Xylose-4-¹³C; (+)-Xylose-4-¹³C; Wood sugar-4-¹³C	Isotope-Labeled Compounds Endogenous Metabolite	Others
Xylose-4- ¹³C is the ¹³C labeled Xylose.

HY-N0666S7

*L-Aspartic acid-1,4-13C2,15N*	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease
L-Aspartic acid-1,4- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-16562AR

Irinotecan hydrochloride (Standard) (+)-Irinotecan hydrochloride (Standard); CPT-11 hydrochloride (Standard); VAL-413 (Standard)	Reference Standards Topoisomerase Autophagy	Cancer
Irinotecan (hydrochloride) (Standard) is the analytical standard of Irinotecan (hydrochloride). This product is intended for research and analytical applications. Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-W017443S4

*L-Asparagine-1,2,3,4-13C4 monohydrate*	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis DNA/RNA Synthesis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
L-Asparagine-1,2,3,4- ¹³C₄ monohydrate is the ¹³C labeled labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-B2156S1

*Menaquinone-4-13C6* Vitamin K2(MK-4)-¹³C₆; Menaquinone K4-¹³C₆	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
Menaquinone-4- ¹³C₆ is the ¹³C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

Cat. No.	Product Name

HY-L018

TGF-beta/Smad Compound Library

413 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 413 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

Cat. No.	Product Name	Type

HY-W035051

TSPP tetrasodium	Biochemical Assay Reagents
TSPP tetrasodium is a photosensitizer that has shown impressive effects in in vivo regression of cancer and microorganism infections (Ex: 413 nm, Em: 640 nm) .

HY-W127841

Citric acid-2,4-13C2

Biochemical Assay Reagents

Citric acid-2,4- ¹³C₂ is the ¹³C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .

Cat. No.	Product Name	Target	Research Area

HY-P3171

*Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13)*	Biochemical Assay Reagents	Others
Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) is a melanotropin cyclic peptide. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) ultraprolongs melanotropic activity in frog and lizard skin model with great agonisim. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) exhibits a complete resistance to tryptic degradation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16562A

Irinotecan hydrochloride 70+ Cited Publications (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; VAL-413	Alkaloids Classification of Application Fields Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Source Classification Cancer	Topoisomerase Autophagy
Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-N6771

Cyclopiazonic acid 5+ Cited Publications	Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Other Diseases Disease Research Fields Indole Alkaloids Source Classification	Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV
Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B ^[1][4][5].

HY-N15387

Hericenone J	Monophenols Microorganisms Phenols Source Classification	Drug Derivative
Hericenone J (Compound 6) is an aromatic compound with anticancer activity, which is found in Hericium erinaceum. Hericenone J is cytotoxic and can significantly reduce the viability of HL-60 human acute promyelocytic leukemia cells with an IC₅₀ value of 4.13 μM. Hericenone J is promising for research of leukemia .

HY-N8583

*6α,16,18-Trihydroxycleroda-3(4),13(14)-dien-15,16-olide*	Terpenoids Diterpenoids Plants Annonaceae Monoon simiarum (Buch.-Ham. ex Hook. f. & Thomson) B. Xue & R. M. K. Saunders Source Classification	Others
6α,16,18-Trihydroxycleroda-3(4),13(14)-dien-15,16-olide is a Diterpenoids product that can be isolated from the herbs of Polyalthia cheliensis .

HY-16562AR

Irinotecan hydrochloride (Standard) (+)-Irinotecan hydrochloride (Standard); CPT-11 hydrochloride (Standard); VAL-413 (Standard)	Alkaloids Structural Classification Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Source Classification	Reference Standards Topoisomerase Autophagy
Irinotecan (hydrochloride) (Standard) is the analytical standard of Irinotecan (hydrochloride). This product is intended for research and analytical applications. Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-N15578

Actinidioionoside	Borago officinalis L. Lignans Phenylpropanoids Plants Boraginaceae Source Classification	Others
Actinidioionoside (Compound 2) is a megastigmane glucoside compound found in Borago officinalis L. Actinidioionoside has DPPH free radical scavenging activity (IC₅₀: 41.3 μM). Actinidioionoside has no significant cytotoxicity against A549 human lung cancer cells (IC₅₀ > 100 μM). Actinidioionoside can be used in antioxidant studies .

Species:	Human (1) Mouse (1)
Tag:	His (1) Strep (1) Tag Free (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P79080

	Nodal Protein, Mouse Nodal; Tg.413d	Mouse	E. coli
	Nodal protein plays a key role in embryonic development and is integral for mesoderm formation and axial patterning. Its involvement in these fundamental processes underscores its importance in coordinating the complex series of events that determine early embryonic morphogenesis. Nodal Protein, Mouse is the recombinant mouse-derived Nodal protein, expressed by E. coli , with tag free.

HY-P705714

	*LRP2/Megalin Protein, Human (413a.a, HEK293, His-StrepII)* Low-density lipoprotein receptor-related protein 2; LRP2; Glycoprotein 330 (gp330); Megalin; LRP-2	Human	HEK293
	LRP2/Megalin Protein, Human (413a.a, HEK293, His-StrepⅡ) is the recombinant human-derived LRP2/Megalin protein, expressed by HEK293, with C-His and C-StrepⅡ tag.

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Cat. No.	Product Name	Chemical Structure

HY-W750796

Butyric acid-13C4 sodium

Butyric acid-13C4 sodium (Butanoic acid-13C4 sodium) is a stable isotope labeled compound with the activity of promoting cell proliferation and regulating gene expression. Butyric acid-13C4 sodium can be used in metabolic research and compound development to help scientists gain a deeper understanding of the role of short-chain fatty acids in organisms. Butyric acid-13C4 sodium also plays an important role in nutrition and intestinal health research, especially in the regulation of probiotic function and intestinal microbiota.

HY-N0830S

*Palmitic acid-1,2,3,4-13C4*
Palmitic acid-1,2,3,4- ¹³C₄ is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .

HY-100807S2

Quinolinic acid-13C4,15N
Quinolinic acid-13C4, 15N is an isotopic labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.

HY-N0473S5

*L-Tyrosine-4-13C*
L-Tyrosine-4- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-B0152S3

Adenine-13C5

Adenine- ¹³C₅ (6-Aminopurine- ¹³C₅; Vitamin B4- ¹³C₅) is ¹³C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

HY-N7092S5

*D-Fructose-4-13C*
D-Fructose-4- ¹³C is the ¹³C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants .

HY-N0666S6

*L-Aspartic acid-1,4-13C2*
L-Aspartic acid-1,4- ¹³C₂ is the ¹³C-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-W127841

Citric acid-2,4-13C2

HY-B0389S11

*D-Glucose-4-13C*
D-Glucose-4- ¹³C is the ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response .

HY-139959S

(±)12(13)-EpOME-d4
(±)12(13)-EpOME-d₄ is the deuterium labeled (±)12(13)-EpOME .

HY-140346AS

L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride

L-Azidohomoalanine-1,2,3,4- ¹³C₄ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Azidohomoalanine hydrochloride. L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W017163S

7-Methylxanthine-2,4,5,6-13C4, 1,3-15N2 (with variable 15N labeling at N9)
7-Methylxanthine-2,4,5,6- ¹³C₄, 1,3- ¹⁵N₂ (with variable ¹⁵N labeling at N₉) is the ¹³C and ¹⁵N labeled 7-Methylxanthine . 7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi .

HY-18341S4

L-Thyroxine-13C6-1
L-Thyroxine- ¹³C₆-1 (Levothyroxine- ¹³C₆-1; T4- ¹³C₆-1) is a ¹³C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .

HY-116956S3

*D-Erythrose-4-13C*
D-Erythrose-4- ¹³C is the ¹³C labeled D-Erythrose .

HY-N0667S4

L-Asparagine-4-13C monohydrate

L-Asparagine-4- ¹³C monohydrate is the ¹³C-labeled L-Asparagine monohydrate (HY-W017443).L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N0537S6

*Xylose-4-13C*
Xylose-4- ¹³C is the ¹³C labeled Xylose.

HY-N0666S7

*L-Aspartic acid-1,4-13C2,15N*
L-Aspartic acid-1,4- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions .

HY-W017443S4

L-Asparagine-1,2,3,4-13C4 monohydrate

L-Asparagine-1,2,3,4- ¹³C₄ monohydrate is the ¹³C labeled labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-B2156S1

*Menaquinone-4-13C6*
Menaquinone-4- ¹³C₆ is the ¹³C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.

HY-16562AS

Irinotecan-d5 hydrochloride
Irinotecan-d₅ hydrochloride is deuterated labeled Irinotecan hydrochloride (HY-16562A). Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-16562S

Irinotecan-d10
Irinotecan-d₁₀ is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-107494S3

13-cis-4-Oxoretinoic acid-d6
13-cis-4-Oxoretinoic acid-d₆ (4-Keto 13-cis-retinoic acid-d₆; 4-Oxoisotretinoin-d₆; Ro 22-6595-d₆) is the deuterium labeled 13-cis-4-Oxoretinoic acid (HY-107494). 13-cis-4-Oxoretinoic acid (4-Keto 13-cis-retinoic acid) is a metabolite of vitamin A in human plasma .

HY-143662S

(±)12(13)-DiHOME-d4
(±)12(13)-DiHOME-d₄ is the deuterium labeled (±)12(13)-DiHOME .

HY-W009362AS

DL-Isocitric acid-13C4 trisodium hydrate
DL-Isocitric acid-13C4 (trisodium hydrate) is a ¹³C labeled DL-Isocitric acid.

HY-B0084S4

Dienogest-13C,15N,d4

Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the ¹³C, ¹⁵N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia .

HY-15407S3

Sacubitril-13C4
Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC₅₀=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19 .

HY-59354S1

1,2-Dihydropyridazine-3,6-dione-3,4,5,6-13C4
1,2-Dihydropyridazine-3,6-dione-3,4,5,6- ¹³C₄ (1,2-Dihydro-3,6-pyridazine- ¹³C₄-dione) is ¹³C labeled Maleic hydrazide. Maleic hydrazide is extensively used as a systemic plant growth regulator and as a herbicide. Maleic hydrazide acts as an inhibitor of the synthesis of nucleic acids and proteins .

HY-B0152S2

Adenine-13C5,15N5

Adenine- ¹³C₅,15C5 (6-Aminopurine- ¹³C₅,15C5; Vitamin B4- ¹³C₅,15C5) is ¹³C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.

HY-N6771S

Cyclopiazonic acid-13C20

Cyclopiazonic acid- ¹³C₂₀ is the ¹³C-labeled Cyclopiazonic acid (HY-N6771). Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B .

HY-W704141

2-(Dibenzylamino)propane-1,1,3,3-d4-1,3-diol
2-(Dibenzylamino)propane-1,1,3,3-d₄-1,3-diol is the deuterium labeled 2-(Dibenzylamino)propane-1,3-diol (HY-W103677).

HY-W707854

Mieshuan-d4
Mieshuan-d₄ (1-(3'-Pyridylmethyl)-3-(4'-nitrophenyl)urea-d₄) is the deuterium labeled Mieshuan.

HY-W722107

Timonacic-d4
Timonacic-d₄ (1,3-Thiazolidine-4-carboxylic acid-d₄) is deuterium labeled Timonacic. Timonacic (1,3-Thiazolidine-4-carboxylic acid) is a thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects, and it can be used to study acute illnesses and liver diseases, by inducing reversal, it is also used in research on certain cancer cases .

Host:	Mouse (1) Rabbit (1)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	ICC/IF (1) WB (2) FC (1) ELISA (1)
Isotype:	IgG (1) IgG2b (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80942

	GLO1 Antibody (YA413) Aldoketomutase; glo1; GLOD1; Glx I; GLYI	WB, FC	Human, Mouse, Rat
	GLO1 Antibody (YA413) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GLO1.

HY-P85851

	G3BP Antibody (YA5543) Ras GTPase-activating protein-binding protein 1; G3BP-1; EC 3.6.4.13; ATP-dependent DNA helicase VIII; hDH VIII; GAP SH3 domain-binding protein 1;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	G3BP Antibody (YA5543) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to G3BP.

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Cat. No.	Product Name		Classification

HY-15843

MIR96-IN-1		Azide
MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with K_ds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively . MIR96-IN-1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140346AS

*L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride*		Azide PROTAC Synthesis
L-Azidohomoalanine-1,2,3,4- ¹³C₄ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Azidohomoalanine hydrochloride. L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-15661A

*OSI-413* free base** CP 373413		Alkynes
OSI-413 (free base) (CP 373413) is a major metabolite of Erlotinib (HY-50896). Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC₅₀ of 2 nM for human EGFR .

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