Civorebrutinib
Civorebrutinib (WS-413) is a selective, orally active BTK and TEC inhibitor with an IC50 of <100 nM for both targets. Civorebrutinib inhibits B cell activation. Civorebrutinib significantly suppresses the in vivo growth of diffuse large B-cell lymphoma cells. Civorebrutinib can be used for the research of diffuse large B-cell lymphoma.
For research use only. We do not sell to patients.
- CAS No.: 2155853-43-1
- Formula: C23H22ClN7O2
- Molecular Weight:463.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Civorebrutinib (1 h) exerts weak or no inhibitory effect on T cell activation, with an IC50 >4000 nM[1].
Civorebrutinib (30 min) inhibits the activation of B cells in whole blood, with an IC50 of <200 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD.SCID (immunocompromised, TMD-8 cells implanted subcutaneously)[1]
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Dosage:30 mg/kg; 25 mg/kg; 50 mg/kg
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Administration:p.o.; daily; 21 days; p.o.; twice daily; 21 days
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Result:Significantly suppressed the growth of TMD-8 tumors in vivo, with tumor volume substantially lower than the vehicle control and comparable to the positive control Ibrutinib at 30 mg/kg daily.
Showed potent tumor growth inhibition, with tumor volumes remaining at low levels similar to ibrutinib groups at 25 mg/kg twice daily and 50 mg/kg daily.
Chemical Information
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CAS No. 2155853-43-1
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Molecular Weight 463.92
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Formula C23H22ClN7O2
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SMILES
ClC(C=C1)=CN=C1OC2=CC=C(C3=NN([C@@H]4CCC5(CC5)N(C#N)C4)C(N)=C3C(N)=O)C=C2
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Synonyms
WS-413
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Civorebrutinib Related Classifications
HY-111781 Related Classifications
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