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Cat. No.: HY-111781S

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Civorebrutinib-d₄

Name: Civorebrutinib-d4
Brand: MedChemExpress
SKU: HY-111781S
Availability: PreOrder

(Synonyms: WS-413-d₄)

Civorebrutinib-d₄ (WS-413-d₄) is the deuterated-labeled Civorebrutinib (HY-111781). Civorebrutinib (WS-413) is a selective, orally active BTK and TEC inhibitor with an IC₅₀ of <100 nM for both targets. Civorebrutinib inhibits B cell activation. Civorebrutinib significantly suppresses the in vivo growth of diffuse large B-cell lymphoma cells. Civorebrutinib can be used for the research of diffuse large B-cell lymphoma.

For research use only. We do not sell to patients.

Formula: C₂₃H₁₈D₄ClN₇O₂
Molecular Weight:467.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Civorebrutinib-d₄ Chemical Structure

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
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Biological Activity

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 2155853-43-1
Molecular Weight 467.94
Formula C₂₃H₁₈D₄ClN₇O₂
SMILES

ClC(C=C1)=CN=C1OC2=C([2H])C([2H])=C(C3=NN([C@@H]4CCC5(CC5)N(C#N)C4)C(N)=C3C(N)=O)C([2H])=C2[2H]
Synonyms

WS-413-d₄
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.