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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
5-aza
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "5-aza" in MCE Product Catalog:
177
177 Publications Verification
Synonyms: 5-aza-2'-deoxycytidine; 5-aza-CdR; NSC 127716
Research Areas:
Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell Apoptosis. Decitabine has potent anticancer activity .
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5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides .
Synonyms: 5-aza-T-dCyd; NTX-301
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5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA methyltransferase I (DNMT1) inhibitor. 5-Aza-4'-thio-2'-deoxycytidine, a sulfur-containing deoxy-cytidine analog, has the potential for DNA hypomethylating and has antitumor effects .
Synonyms: 5-aza-2'-deoxycytidine (Standard); 5-aza-CdR (Standard); NSC 127716 (Standard)
Research Areas:
Decitabine (Standard) is the analytical standard of Decitabine. This product is intended for research and analytical applications. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .
Cat. No.: HY-50071
CAS No.: 211555-30-5
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6-Amino-5-nitropyridin-2-one is a pyridine base and used as a nucleobase of hachimoji DNA, in which it pairs with 5-aza-7-deazaguanine .
Cat. No.: HY-154399
CAS No.: 455951-65-2
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5-Aza-3’-deoxycytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
Cat. No.: HY-154400
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5-Aza-3’-beta-methylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
Cat. No.: HY-W767228
Synonyms: 5-aza-2'-deoxy cytidine-15N4
Cat. No.: HY-154398
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5-Aza-xylo-cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
Cat. No.: HY-A0004S
Synonyms: 5-aza-2'-deoxycytidine-13C5; 5-aza-CdR-13C5; NSC 127716-13C5
Cat. No.: HY-111627R
CAS No.: 67410-64-4
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5-Aza-7-deazaguanine (Standard) is the analytical standard of 5-Aza-7-deazaguanine (HY-111627). This product is intended for research and analytical applications. 5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides .
Cat. No.: HY-185899
CAS No.: 72052-96-1
Synonyms: 5-aza-2'-deoxycytidine-5′-triphosphate
5-Aza-dCTP (5-Aza-2'-deoxycytidine-5′-triphosphate) is a nucleotide analog that acts as a substrate for mammalian DNA polymerase α (Km = 3.0 μM) and a weak competitive inhibitor of this enzyme (Ki = 4.3 μM). 5-Aza-dCTP inhibits DNA polymerase α via incorporation into DNA through Watson-Crick base pairing, inhibits DNA methyltransferases via incorporation into hemimethylated DNA, and induces mutations in HIV-1 via incorporation into viral DNA during synthesis. 5-Aza-dCTP reverses the inhibitory effect of dTTP on dCMP deaminase, and allosterically activates dCMP deamination to the same extent as dCTP. 5-Aza-dCTP is applicable to research related to leukemia and type 1 human immunodeficiency virus infection .
Cat. No.: HY-W778087
CAS No.: 106966-55-6
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5-Aza-2'-deoxy-6-oxo cytidine is a monomeric raw material that can be used for nucleic acid synthesis.
Cat. No.: HY-A0004B
CAS No.: 879492-57-6
Synonyms: 5-aza-2'-deoxycytidine methanesulfonate; 5-aza-CdR methanesulfonate; NSC 127716 methanesulfonate
Research Areas:
Decitabine methanesulfonate (5-Aza-2'-deoxycytidine methanesulfonate) is an orally active Deoxycytidine analogue antimetabolite and DNA methyltransferase inhibitor. Decitabine methanesulfonate incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine methanesulfonate induces cell G2/M arrest and cell Apoptosis. Decitabine has potent anticancer activity [5] .
Cat. No.: HY-171938
CAS No.: 929904-98-3
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5-Aza-N6-benzoyl-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
