5-Aza-xylo-cytidine
5-Aza-xylo-cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
For research use only. We do not sell to patients.
- Formula: C8H12N4O5
- Molecular Weight:244.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 5637 | IC50 |
1.73 μM
Compound: 5-Aza-cytidine
|
Antiproliferative activity against human 5637 cells after 96 hrs by crystal violet assay
Antiproliferative activity against human 5637 cells after 96 hrs by crystal violet assay
|
[PMID: 18434163] |
| A-427 | IC50 |
0.63 μM
Compound: 5-Aza-cytidine
|
Antiproliferative activity against human A427 cells after 96 hrs by crystal violet assay
Antiproliferative activity against human A427 cells after 96 hrs by crystal violet assay
|
[PMID: 18434163] |
| HEK293 | IC50 |
>500 μM
Compound: azacitidine
|
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
|
[PMID: 23241029] |
| HT-29 | IC50 |
3800 nM
Compound: 5-azacytidine
|
Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay
Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay
|
[PMID: 2778449] |
| KB | IC50 |
0.23 μg/mL
Compound: 80
|
Growth inhibition of human KB cells
Growth inhibition of human KB cells
|
[PMID: 29135244] |
| KYSE-70 cell line | IC50 |
1.59 μM
Compound: 5-Aza-cytidine
|
Antiproliferative activity against human KYSE70 cells after 96 hrs by crystal violet assay
Antiproliferative activity against human KYSE70 cells after 96 hrs by crystal violet assay
|
[PMID: 18434163] |
| L1210 | IC50 |
4.09 M
Compound: AZC
|
Compound was tested for its inhibitory activity against L1210 lymphoid leukemia
Compound was tested for its inhibitory activity against L1210 lymphoid leukemia
|
[PMID: 3806615] |
| MCF7 | IC50 |
6.78 μM
Compound: 5-Aza-cytidine
|
Antiproliferative activity against human MCF7 cells after 96 hrs by crystal violet assay
Antiproliferative activity against human MCF7 cells after 96 hrs by crystal violet assay
|
[PMID: 18434163] |
| P388 | IC50 |
5 μM
Compound: 5-azacytidine
|
Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay
Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay
|
[PMID: 2778449] |
Chemical Information
-
Molecular Weight 244.20
-
Formula C8H12N4O5
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SMILES
NC(N=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)=NC1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)