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Results for "

Aminopyrimidine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Antibiotic (1) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (7) DNA/RNA Synthesis (1) Drug Intermediate (2) EGFR (4) Endogenous Metabolite (1) Endothelin Receptor (1) Ephrin Receptor (1) Epigenetic Reader Domain (1) GCGR (1) GnRH Receptor (1) Insulin Receptor (1) Isotope-Labeled Compounds (2) Melanocortin Receptor (1) MOFs (1) mTOR (1) p38 MAPK (1) Parasite (3) PI3K (1) PSMA (2) Radionuclide-Drug Conjugates (RDCs) (4) Reference Standards (1) Renin (1) Ser/Thr Protease (1) Somatostatin Receptor (5) VEGFR (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Endocrinology (3) Infection (1) Metabolic Disease (5) Neurological Disease (5)

By Targets:

Amyloid-β (1)

Antibiotic (1)

Apoptosis (1)

Bacterial (1)

Biochemical Assay Reagents (7)

DNA/RNA Synthesis (1)

Drug Intermediate (2)

EGFR (4)

Endogenous Metabolite (1)

Endothelin Receptor (1)

Ephrin Receptor (1)

Epigenetic Reader Domain (1)

GCGR (1)

GnRH Receptor (1)

Insulin Receptor (1)

Isotope-Labeled Compounds (2)

Melanocortin Receptor (1)

MOFs (1)

mTOR (1)

p38 MAPK (1)

Parasite (3)

PI3K (1)

PSMA (2)

Radionuclide-Drug Conjugates (RDCs) (4)

Reference Standards (1)

Renin (1)

Ser/Thr Protease (1)

Somatostatin Receptor (5)

VEGFR (1)

By Research Areas:

Cancer (13)

Cardiovascular Disease (1)

Endocrinology (3)

Infection (1)

Metabolic Disease (5)

Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P4070

Insulin icodec	Insulin Receptor	Metabolic Disease
Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA_1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus .

HY-P5362

NODAGA-LM3	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Neurological Disease Cancer
NODAGA-LM3 is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC₅₀ = 1.3 nM). NODAGA-LM3 does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. ⁶⁸Ga-labeled NODAGA-LM3 can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .

HY-41340

2-Aminopyrimidine	Biochemical Assay Reagents Drug Intermediate	Others
2-Aminopyrimidine is an important heterocyclic intermediate. 2-Aminopyrimidine can undergo various reactions such as alkylation and acylation, and can be used for the synthesis of other active compounds .

HY-111138

CZC-8004 CZC-00008004	EGFR VEGFR	Cancer
CZC-8004 (CZC-00008004) is a pan-kinase inhibitor. CZC-8004 has IC₅₀ values of 650 and 437 nM for EGFR WT and VEGFR2 V916M, respectively. CZC-8004 can be used in the study of cancer .

HY-P2336A

CCZ01048 TFA 3 Publications Verification	Melanocortin Receptor	Cancer
CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a K_i of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma .

HY-60351

5-Aminopyrimidine	Biochemical Assay Reagents	Others
5-Aminopyrimidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-10812

GNE-490	PI3K mTOR	Cancer
GNE-490, a (thienopyrimidin-2-yl)aminopyrimidine, is a potent pan-PI3K inhibitor with IC₅₀s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC₅₀=750 nM). GNE-490 shows potent suppression efficacy profile against MCF7.1 breast cancer xenograft model .

HY-P10341

ZP3022	GCGR	Metabolic Disease
ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin that has the ability to sustainably improve glycemic control. Additionally, ZP3022 can effectively increase β-cell mass, promote β-cell proliferation, and enhance the function of pancreatic islets. ZP3022 can be used in anti-diabetic research .

HY-103441

JNJ28871063 hydrochloride	EGFR	Cancer
JNJ28871063 hydrochloride is an orally active, highly selective and ATP competitive pan-ErbB kinase inhibitor with IC₅₀ values of 22 nM, 38 nM, and 21 nM for ErbB1, ErbB2, and ErbB4, respectively. JNJ28871063 hydrochloride inhibits phosphorylation of functionally important tyrosine residues in both EGFR and ErbB2. JNJ28871063 hydrochloride crosses the blood-brain barrier and has antitumor activity in human tumor xenograft models that overexpress EGFR and ErbB2 .

HY-132994

TVD-0003510	Biochemical Assay Reagents	Others
TVD-0003510 is a carboxamide derivative, and involves in synthesis of (2-((6-(2-aminopyrimidine-5-carboxamido)-8-methoxy-3,4-dihydro-2H-pyrimido[1,2-c]quinazolin-9-yl)oxy)ethyl)piperazine-l-carboxylate (C51), as a part of tert-butyl2-(4-hydroxyphenyl)acetate .

HY-41340R

*2-Aminopyrimidine* (Standard)**	Biochemical Assay Reagents Reference Standards Drug Intermediate	Others
2-Aminopyrimidine (Standard) is the analytical standard of 2-Aminopyrimidine (HY-41340). This product is intended for research and analytical applications. 2-Aminopyrimidine is an important heterocyclic intermediate. 2-Aminopyrimidine can undergo various reactions such as alkylation and acylation, and can be used for the synthesis of other active compounds.

HY-W720946

*2-Aminopyrimidine-d2*	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
2-Aminopyrimidine-d₂ is the deuterium labeled 2-Aminopyrimidine (HY-41340). 2-Aminopyrimidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-60351S

*5-Aminopyrimidine-d3*	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
5-Aminopyrimidine-d₃ is the deuterated form of 5-Aminopyrimidine. 5-Aminopyrimidine is a biochemical reagent that can serve as a biomaterial or an organic compound for research related to life sciences. Its derivatives exhibit antioxidant activity .

HY-P11004

A3-APO	Bacterial Antibiotic	Infection
A3-APO is an antimicrobial peptide. A3-APO has a significant antimicrobial activity by a dual mode of action with both membrane disintegration and intracellular target inhibition. A3-APO can deactivate bacterial toxins and increase the expression of anti-inflammatory cytokines (such as IL-4 and IL-10), without antimicrobial resistance. A3-APO accelerates burn wounds healing in mice infection model of Acinetobacter baumannii and Staphylococcus aureus .

HY-P10472

Azaline B	GnRH Receptor	Endocrinology
Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC₅₀ of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception .

HY-P4757

N1-Glutathionyl-spermidine disulfide	Parasite	Others
N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .

HY-P11243

EphA4 agonist compound 23	Ephrin Receptor	Neurological Disease
EphA4 agonist compound 23 is a novel EphA4 agonist peptide mimic. EphA4 agonist compound 23 exhibits high affinity, high selectivity, and significant receptor activation ability. EphA4 agonist compound 23 is commonly used in the study of neurodegenerative diseases .

HY-P2434

AP102	Somatostatin Receptor	Neurological Disease Metabolic Disease Cancer
AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC₅₀: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research .

HY-P5362A

NODAGA-LM3 TFA	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Cancer
NODAGA-LM3 TFA is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC₅₀ = 1.3 nM). NODAGA-LM3 TFA does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 TFA shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. ⁶⁸Ga-labeled NODAGA-LM3 TFA can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

HY-151469

Chitinase-IN-4	Parasite	Others
Chitinase-IN-4 (compound 8f), an azo-aminopyrimidine derivative, is a potent, selective OfChi-h inhibitor with an IC₅₀ value of 0.1 μM. Chitinase-IN-4 has good insecticidal activity. Chitinase-IN-4 can be used in research of green pest control and management .

HY-30138

*2-Amino-4-chloropyrimidine*	Biochemical Assay Reagents	Others
2-Amino-4-chloropyrimidine is an aminopyrimidine derivative .

HY-153538

AP-C2	Ser/Thr Protease	Metabolic Disease
AP-C2 is a potent guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC₅₀ of 5.2 .

HY-149889

EGFR-IN-78	Apoptosis EGFR	Cancer
EGFR-IN-78 (compound A5)，a 2-aminopyrimidine derivative，is a reversible inhibitor of EGFR ^C797S-TK，and also an inducer of apoptosis. EGFR-IN-78 shows anti-proliferative activity，inhibits EGFR phosphorylation and arrests cell cycle at G2/M phase .

HY-177141

CDD-1154	Epigenetic Reader Domain	Endocrinology
CDD-1154 is an aminopyrimidine analog. CDD-1154 is a BRDT-BD2 inhibitor (IC₅₀: 139 nM). CDD-1154 is used in male contraceptive research .

HY-173501

EGFR-IN-157	EGFR	Cancer
EGFR-IN-157 (compound IIB-5) is a potent EGFR inhibitor with an IC₅₀ of 18.81 nM. EGFR-IN-157 can be used in the study of non-small cell lung cancer (NSCLC) .

HY-151470

Chitinase-IN-5	Parasite	Others
Chitinase-IN-5 (8i) is a potent chitinase OfChi-h inhibitor with an IC₅₀ value of 0.051 μM. Chitinase-IN-5 shows good insecticidal activity, it can be used for the research of green pest control and management .

HY-P2075

EMD 55068	Renin	Endocrinology
EMD 55068 is a renin antagonist. EMD 55068 inhibits the uptake of taurocholate .

HY-W112264

*5,5'-(5-Aminopyrimidine-4,6-diyl)diisophthalic acid*	MOFs	Others
5,5'-(5-Aminopyrimidine-4,6-diyl)diisophthalic acid is a metal-organic framework (MOF).

HY-P10876

mcK6A1	Amyloid-β	Neurological Disease
mcK6A1 is an inhibitor for the aggregation of amyloid-β (Aβ), that selectively binds to the 16KLVFFA21 segment of Aβ42, forms an extended β-folded structure, and inhibits the formation of Aβ42 oligomers. mcK6A1 can be used in research of Alzheimer's disease and other amyloid-related diseases .

HY-W653715

Formylaminopyrimidine	Endogenous Metabolite	Metabolic Disease
Formylaminopyrimidine is a member of the class of aminopyrimidine. Formylaminopyrimidine is a hydrolysis product of thiamin.

HY-180824

p38-α MAPK-IN-11	p38 MAPK	Neurological Disease
P38-α MAPK-IN-11 (Compound 4C) is a selective inhibitor of P38α MAPK that can cross the blood-brain barrier with an IC₅₀ value of 43 nM. P38-α MAPK-IN-11 has extremely low inhibitory activity against other MAPK subtypes, namely p38β, p38γ, and p38δ, with IC₅₀ values of > 100 nM, > 100 nM, and 48.6 mM respectively. P38-α MAPK-IN-11 exhibits outstanding neuroprotective effects and anti-neuroinflammatory effects in Alzheimer's disease-like rat models. P38-α MAPK-IN-11 can be used for the study of Alzheimer's disease .

HY-123599

IACS-4619	DNA/RNA Synthesis	Cancer
IACS-4619 (compound 4) is a highly selective 2-aminopyrimidine-based MTH1 (MutT homolog 1) inhibitor (IC₅₀=0.2 nM). IACS-4619 inhibits MTH1 by blocking its hydrolysis of oxidized purine nucleotides such as 8-oxo-dGTP, thereby preventing MTH1 from inhibiting the incorporation of oxidized nucleotides into DNA. IACS-4619 significantly inhibits endogenous MTH1 activity in MTH1-overexpressing U2OS cells, but without antiproliferative or cytotoxic effects on various human cancer and normal cell lines. IACS-4619 can be used in oncology research related to the MTH1 target .

HY-P11488

JR11-PEG3-DOTA-PSMA-03	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor PSMA	Cancer
JR11-PEG3-DOTA-PSMA-03 (Compound 2) is an RDC-related compound containing the chelating agent DOTA (HY-W053583), the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-DOTA-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC₅₀ s of 94.0 nM, 81.8 nM, respectively. JR11-PEG3-DOTA-PSMA-03 can be radiolabeled with [ ⁶⁸Ga]. [ ⁶⁸Ga] radiolabeled JR11-PEG3-DOTA-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .

HY-P11485

JR11-PEG3-HBED-CC-PSMA-03	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor PSMA	Cancer
JR11-PEG3-HBED-CC-PSMA-03 (Compound 1) is an RDC-related compound containing the chelating agent HBED-CC, the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-HBED-CC-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC₅₀ s of 59.2 nM, 57.0 nM, respectively. JR11-PEG3-HBED-CC-PSMA-03 can be radiolabeled with [ ⁶⁸Ga]. [ ⁶⁸Ga] radiolabeled JR11-PEG3-HBED-CC-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .

Cat. No.	Product Name	Type