1. Protein Tyrosine Kinase/RTK
  2. Bcr-Abl

CZC-8004 (Synonyms: CZC-00008004)

Cat. No.: HY-111138
Handling Instructions

CZC-8004 is a pan-kinase inhibitor and binds a range of tyrosine kinases, including ABL kinase.

For research use only. We do not sell to patients.

CZC-8004 Chemical Structure

CZC-8004 Chemical Structure

CAS No. : 916603-07-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 380 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

CZC-8004 is a pan-kinase inhibitor and binds a range of tyrosine kinases, including ABL kinase.

Solvent & Solubility
In Vitro: 

DMSO : 77.5 mg/mL (250.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2327 mL 16.1634 mL 32.3269 mL
5 mM 0.6465 mL 3.2327 mL 6.4654 mL
10 mM 0.3233 mL 1.6163 mL 3.2327 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.58 mg/mL (8.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.58 mg/mL (8.34 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.58 mg/mL (8.34 mM); Clear solution

References
Molecular Weight

309.34

Formula

C₁₇H₁₆FN₅

CAS No.

916603-07-1

SMILES

FC1=CN=C(NC2=CC=C(CN)C=C2)N=C1NC3=CC=CC=C3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

Product Name:
CZC-8004
Cat. No.:
HY-111138
Quantity:

CZC-8004

Cat. No.: HY-111138