916603-07-1
916603-07-1
Chemical Structure
CZC-8004
Synonym(s): CZC-00008004
- CAS No.: 916603-07-1
- Formula:C17H16FN5
- Molecular Weight:309.34
IUPAC Name: N2-(4-(aminomethyl)phenyl)-5-fluoro-N4-phenylpyrimidine-2,4-diamine
InChIKey: UKOHFWNBTUJMMN-UHFFFAOYSA-N
SMILES: FC1=CN=C(NC2=CC=C(CN)C=C2)N=C1NC3=CC=CC=C3
Biological Activity: CZC-8004 (CZC-00008004) is a pan-kinase inhibitor. CZC-8004 has IC50 values of 650 and 437 nM for EGFR WT and VEGFR2 V916M, respectively. CZC-8004 can be used in the study of cancer[1][2].
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CZC-8004 | 99.81% | CZC-8004 (CZC-00008004) is a pan-kinase inhibitor. CZC-8004 has IC50 values of 650 and 437 nM for EGFR WT and VEGFR2 V916M, respectively. CZC-8004 can be used in the study of cancer. | ||||||||||||||||||||
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CZC-8004 (Standard) | ≥98% | CZC-8004 (Standard) is the analytical standard of CZC-8004 (HY-111138). This product is intended for research and analytical applications. CZC-8004 (CZC-00008004) is a pan-Kinase inhibitor. CZC-8004 has IC50 values of 650 and 437 nM for EGFR WT and VEGFR2 V916M, respectively. CZC-8004 can be used in the study of cancer. | ||||||||||||||||||||
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References
- [1]. Ying ZD, et, al. Integrated in silico-in vitro analysis of systematic kinase gatekeeper mutation effects on pan-kinase inhibitors in targeted liver cancer therapy. J Chin Chem Soc. 2020 Oct 29;1-10.
- [2]. Deane FM, et, al. FD5180, a Novel Protein Kinase Affinity Probe, and the Effect of Bead Loading on Protein Kinase Identification. ACS Omega. 2017 Jul 31;2(7):3828-3838. [Content Brief]
