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Analog-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Nucleoside Antimetabolite/Analog (7) ADC Payload (4) Akt (2) Amino Acid Derivatives (3) Androgen Receptor (1) Antibiotic (1) Apoptosis (4) Autophagy (1) AUTOTACs (2) Bacterial (3) Biochemical Assay Reagents (3) Cannabinoid Receptor (1) Cholecystokinin Receptor (1) Cytochrome P450 (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (3) Drug Derivative (10) Drug Intermediate (8) Drug Isomer (2) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (2) EGFR (1) Endogenous Metabolite (5) FXR (1) GnRH Receptor (2) HCV (1) HDAC (1) HIV Protease (1) IFNAR (1) IKK (1) Interleukin Related (1) JAK (1) Keap1-Nrf2 (1) Ligands for Target Protein for PROTAC (1) MDM-2/p53 (1) Microtubule/Tubulin (1) Mitophagy (1) Molecular Glues (1) N-myristoyltransferase (1) NADPH Oxidase (1) Opioid Receptor (1) P-glycoprotein (1) Parasite (1) Phosphatase (1) Phospholipase (1) Phosphoramidites (1) Poly(ADP-ribose) Glycohydrolase (PARG) (1) Prostaglandin Receptor (6) Protease Activated Receptor (PAR) (1) PTHR (1) Ras (1) SARS-CoV (1) Sirtuin (1) Somatostatin Receptor (1) Topoisomerase (1) Transketolase (1) TRP Channel (1) Vasopressin Receptor (1)
By Research Areas:	Cancer (35) Cardiovascular Disease (3) Endocrinology (8) Infection (8) Inflammation/Immunology (6) Metabolic Disease (6) Neurological Disease (9)
Click Chemistry:	Azide (2)
Oligonucleotides:	Adenosine (2) Guanosine (1) Nucleotide Analogs (2) Nucleoside Analogs (3) Adenine (1) Phosphoramidites (1) Adenine Nucleotide (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Click Chemistry

Oligonucleotides

Targets Recommended: Nucleoside Antimetabolite/Analog

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137883

Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Br	Drug-Linker Conjugates for ADC	Cancer
Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Br is a drug-linker conjugate for ADC that can be used to synthesize ABBV-154, ABBV-927, ABBV-368 or their analogs .

HY-136203

Resveratrol analog 1	IKK Autophagy Mitophagy Sirtuin	Inflammation/Immunology Cancer
Resveratrol analog 1 is an analog of Resveratrol (HY-16561), compound 48. Resveratrol is a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.

HY-W008325

Boc-L-Dap-OH	Amino Acid Derivatives	Others
Boc-L-Dap-OH is a Boc-protected derivative of L-2,3-diaminopropionic acid. Boc-L-Dap-OH is an important chiral amino acid derivative. Boc-L-Dap-OH can be generated via the Hofmann rearrangement of Boc-L-asparagine. Boc-L-Dap-OH serves as a starting material for the preparation of BIM analogs .

HY-107502

Cryptophycin analog 1	ADC Payload	Cancer
Cryptophycin analog 1 is an ADC payload. Cryptophycin analog 1 shows anticancer activity. Cryptophycin analog 1 displays cell activity an order of magnitude more potent than approved ADC payloads MMAE and DM1 ^[1].

HY-115666

COH34 analog 1	Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
COH34 analog 1, a metabolite, is an oxidized analog of COH34. COH34 is a potent poly(ADP-ribose) glycohydrolase (PARG) inhibitor ^[1].

HY-129355

Duocarmycin analog-1	ADC Payload DNA Alkylator/Crosslinker	Cancer
Duocarmycin analog-1 is an analog of Duocarmycin, and used as an DNA alkylator and ADC cytotoxin ^[1].

HY-W141394

Bz-OMe-rA N-Benzoyl-2′-O-methyladenosine	Nucleoside Antimetabolite/Analog	Others
Bz-OMe-rA is a nucleoside analog .

HY-110407

2'-O,4'-C-Methyleneadenosine LNA-A	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Metabolic Disease
2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog .

HY-121305A

L-Ribulose	Drug Intermediate	Others
L-Ribulose is an L-form pentulose. L-Ribulose serves as a key precursor for the synthesis of L-ribose and L-nucleoside analogs .

HY-172089

TG101209 analog 1	Apoptosis	Cancer
TG101209 analog 1 (Compound 8h) is an inhibitor for *BUB1B* with an IC₅₀ of 10.36 μM. TG101209 analog 1 exhibits cytotoxicity (IC₅₀ for Caki-1 is 1.347 μM), induce necrosis and apoptosis ^[1].

HY-156883

Dasatinib analog-1	Cytochrome P450	Others
Dasatinib analog-1 (compound 5826) inhibits CYP3A4 viability with a K_i value of 5.4 μM. Dasatinib analog-1 blocks the formation of glutathione adducts ^[1].

HY-170515

RNF5 agonist 1	E1/E2/E3 Enzyme	Inflammation/Immunology
RNF5 agonist 1 (analog-1), a structural analog of RNF5 inhibitor inh-02 (HY-123967), is a potent RNF5 agonist. RNF5 agonist 1 increases the ubiquitylation status of ATG4B in F508del-CFTR-expressing CFBE41o- cells ^[1] .

HY-128606

Thiamine diphosphate analog 1	Endogenous Metabolite Transketolase	Neurological Disease Metabolic Disease
Thiamine diphosphate analog 1 is an analog of thiamine diphosphate. Thiamine diphosphate is the active metabolite of vitamin B₁ in organisms. Thiamine diphosphate targets ThDP-dependent enzymes such as transketolase and pyruvate dehydrogenase complex, acting as an essential coenzyme to exert an activating effect. Thiamine diphosphate assists in catalytic reactions in free form and initiates the catalytic cycles of various glucose-metabolizing enzymes. Thiamine diphosphate serves as a diagnostic biomarker and protective factor for Alzheimer's disease. Thiamine diphosphate can be used in research related to metabolism and Alzheimer's disease ^[1] .

HY-131520

(E,E,E)-Farnesyl alcohol azide	Biochemical Assay Reagents	Others
(E,E,E)-Farnesyl alcohol azide can be used as a precursor for the preparation of C15-Azide analogs .

HY-W007880

(R)-D2PM (R)-Diphenylprolinol	Drug Isomer	Neurological Disease
(R)-D2PM ((R)-Diphenylprolinol) is an isomer of the psychoactive substance D2PM and a pyrrolidine analog .

HY-139101A

Guanosine 5'-triphosphate-5'-adenosine triammonium GpppA triammonium	DNA/RNA Synthesis Endogenous Metabolite	Others
Guanosine 5'-triphosphate-5'-adenosine (GpppA) triammonium, a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine triammonium is a fluorescent substrate analog .

HY-15966A

*GSK2110183 analog 1* hydrochloride**	Akt	Cancer
GSK2110183 analog 1 hydrochloride is the structural analogue of GSK2110183.

HY-18298

PD 173955 analog 1	EGFR	Cancer
PD 173955 analog 1 (Compound 26) is an analog of PD 173955 (HY-10395). PD 173955 analog 1 is an inhibitor for EGFR kinase, which exhibits antitumor and toxicological properties. PD 173955 analog 1 exhibits an in silico IC₅₀ of 0.19 μM ^[1].

HY-149441

Indisulam analog-1	Molecular Glues	Cancer
Indisulam analog-1 (Compound 4) is an analog of Indisulam (HY-13650). Indisulam analog-1 recruits *DCAF15-DDB1-DDA1-RBM39* with an EC₅₀ of 1.21 µM. Indisulam analog-1 can be used in the research of colon cancer ^[1].

HY-W098008

Fenbendazole analog-1	Parasite Microtubule/Tubulin	Infection
Fenbendazole analog-1 (compound 9) is a 2-methoxycarbonylamino-derived antiparasitic compound and inhibits rat brain tubulin polymerization. Fenbendazole analog-1 inhibits the growth of the protozoa Giardia lamblia, Entamoeba histolytica, and the worm Trichinella spiralis ^[1].

HY-Z1617

Tigecycline quinone analog-1	Biochemical Assay Reagents	Others
Tigecycline quinone analog-1 (Impurity 3) is an antioxidant. Tigecycline quinone analog-1 (Impurity 3) can be used in antioxidant research ^[1].

HY-171164

Nirmatrelvir analog-1	Drug Intermediate	Infection
Nirmatrelvir analog-1 (Compound 234) is an analog of Nirmatrelvir (HY-138687). Nirmatrelvir analog-1 can be used as drug intermediate for synthesis of cysteine protease ^[1].

HY-156670

Camptothecin analog-1	Topoisomerase	Others
Camptothecin analog-1 (Comp 166) is a camptothecin analog .

HY-12395

Ecteinascidin analog-1	Bacterial	Cancer
Ecteinascidin analog-1 is a useful intermediate for chemical sythesis of Ecteinascidin analogues; Ecteinascidins is a family of tetrahydroisoquinoline alkaloids with wide range of antitumor and antimicrobial activities.

HY-P2178

Dihydrochlamydocin analog-1	HDAC	Cancer
Dihydrochlamydocin analog-1 (compound 2) is a Chlamydocin (HY-115761) analogue that inhibits histone H4 peptide deacetylation with IC₅₀ of 30 nM ^[1].

HY-17658

Apiol analog-1	Apoptosis	Cancer
Apiol analog-1 (Compound 2b) is an analog of Apiol (HY-135217). Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model ^[1] .

HY-177567

Cephalosporin C analog-1	Bacterial	Infection
Cephalosporin C analog-1 is an analogue of Cephalosporin C (HY-B1299). Cephalosporin C has weak resistance to Gram-positive and negative bacteria, is stable to penicillinase, and can be broken down by cephalosporin enzyme. Hydrolysis and removal of side chains to obtain 7-amino-cefenoic acid (7-ACA) is an important raw material for the preparation of semi-synthetic cephalosporin ^[1].

HY-169386

YT 6-2 analog-1	AUTOTACs	Cancer
YT 6-2 analog-1 (compound 2-3) is the p62/SQSTM1 targeting, autophagy-targeting ligand (ATL) of AUTOTAC ATC-324 (HY-169385), which is an bivalent AR (Androgen Receptor) degrader. ATC-324 can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa ^[1].

HY-153511

*Rapamycin analog-2*	Drug Derivative	Cancer
Rapamycin analog-2 (compound A) is a Rapamycin analog .

HY-138880

2′,3′-Di-O-acetylguanosine	Nucleoside Antimetabolite/Analog	Others
2′,3′-Di-O-acetylguanosine is a nucleoside analog .

HY-P11278

Federelin Gonadorelin[6-D-Phe]; [D-Phe6]GnRH	GnRH Receptor	Endocrinology
Federelin (Gonadorelin[6-D-Phe]) is a gonadotropin (GnRH) analog .

HY-126708

Luisol A	ADC Payload Antibiotic	Infection
Luisol A, an aromatic tetraol, is a major metabolite of an estuarine marine actinomycete of the genus Streptomyces. Luisol A, is an anthraquinone antibiotic analog ^.

HY-P4693

(Ser(tBu)6,Azagly10)-LHRH	GnRH Receptor	Endocrinology
(Ser(tBu)6,Azagly10)-LHRH is a potent aza-GLY analog .

HY-121305B

L-Ribulose (solution)	Drug Intermediate	Others
L-Ribulose solution is a 1 M solution of L-Ribulose in water. L-Ribulose is an L-form pentulose. L-Ribulose serves as a key precursor for the synthesis of L-ribose and L-nucleoside analogs .

HY-139101

Guanosine 5'-triphosphate-5'-adenosine GpppA	DNA/RNA Synthesis Endogenous Metabolite	Others
Guanosine 5'-triphosphate-5'-adenosine (GpppA), a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine is a fluorescent substrate analog .

HY-169158

Bortezomib analog 1	Ligands for Target Protein for PROTAC	Cancer
Bortezomib analog 1 is an analog of Bortezomib (HY-10227). Bortezomib analog 1 and can be used to synthesize PROTAC 20S proteasome subunit β5 degrader 1 (HY-169134) ^[1].

HY-163836

HMBPP analog 1	Drug Derivative	Others
HMBPP analog 1 (6e), a Trifluoromethyl analog, is the weakest agonist but the strongest inhibitor HMBPP ELISA response ^[1].

HY-163772

Fraxinellone analog 1	Keap1-Nrf2	Neurological Disease
Fraxinellone analog 1 (compound 2) is a potent and rapid activator of the Nrf2 mediated antioxidant defense system, which protects against glutamate-mediated excitotoxicity and induces the expression of antioxidant genes Gpx4, *Sod1, and Nqo1. Fraxinellone analog 1* has neuroprotective effects and regulatory effects against oxidative stress and inflammation, and can be used in the study of neurodegenerative diseases ^[1].

HY-N10492

Spongionellol A analog 1	P-glycoprotein	Cancer
Spongionellol A analog 1, an analog of Spongionellol A (HY-10491), is a *MDR1* (p-glycoprotein) inhibitor. Spongionellol A analog 1 has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase?dependent apoptosis. Spongionellol A analog 1 can be used in the research of cancers, such as prostate cancer ^[1].

HY-128004

ML171 analog 1	NADPH Oxidase	Cancer
ML171 analog 1 (Crop ID: SR-03000000698-1 SID: 57287906) is a *NOX1* inhibitor. ML171 analog 1 can be used in cancer research ^[1].

HY-135593

LY88074 analog 1	Others	Endocrinology
LY88074 analog 1 is a benzothiophene compound with nitrogen-containing non-basic side chains, Compound 26, extracted from patent EP0747380A1. LY88074 analog 1 is an agent for alleviating the symptoms of post-menopausal symptoms, such as osteoporosis, cardiovascular related pathological conditions, and estrogen-dependent cancer. LY88074 analog 1 can be used alone or in combination with estrogen or progestin ^[1].

HY-135237

DB04760 analog 1	Drug Derivative	Neurological Disease Cancer
DB04760 analog 1 is an analogue of DB04760.

HY-15966

GSK2110183 analog 1	Akt	Cancer
GSK2110183 analog 1 is the structural analogue of GSK2110183.

HY-163704

KRN7000 analog 1	IFNAR Interleukin Related	Inflammation/Immunology Cancer
KRN7000 analog 1 exhibits good Th1-biased immune response through induction of interferon-γ (IFN-γ) and reduction of interleukin-4 (IL-4). KRN7000 analog 1 is potential as an antitumor agent and vaccine adjuvant ^[1].

HY-164828

Rezatapopt analog-1 PC14586 Analog-1	MDM-2/p53	Cancer
Rezatapopt analog-1 (PC14586 analog-1) (1919) is a Rezatapopt (HY-156633) analog. Rezatapopt binds to a pocket created by the TP53 Y220C mutation. Rezatapopt restores p53 tumor suppressor functions by stabilization of the p53 protein structure ^[1].

HY-127178

ML120 analog 1	Phosphatase	Cancer
ML120 analog 1 (compound 1) is a competitive inhibitor with a K_i of 0.69 μM for Hematopoietic protein tyrosine phosphatase (HePTP) ^[1].

HY-120849

Darapladib analog-1	Drug Derivative Phospholipase	Cardiovascular Disease
Darapladib analog-1 (Compound 16) is an O-alkylated Darapladib (HY-10521). Darapladib analog-1 inhibits Lp-PLA₂. Darapladib analog-1 can be used in the research of atherosclerosis ^[1].

HY-171167

Bosutinib analog-1	Drug Derivative	Cancer
Bosutinib analog-1 (compound 74) is an orally active Bosutinib (HY-10158) analog. Bosutinib analog-1 can be used for leukemia research ^[1].

HY-133875

CE3F4 analog 1 1 Publications Verification	Ras	Metabolic Disease
CE3F4 analog 1 is an analogue of CE3F4 ^[1].

HY-77651

Nucleoside-Analog-1 1 Publications Verification	Nucleoside Antimetabolite/Analog HCV	Infection
Nucleoside-Analog-1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Type

HY-W008325

Boc-L-Dap-OH	Biochemical Assay Reagents
Boc-L-Dap-OH is a Boc-protected derivative of L-2,3-diaminopropionic acid. Boc-L-Dap-OH is an important chiral amino acid derivative. Boc-L-Dap-OH can be generated via the Hofmann rearrangement of Boc-L-asparagine. Boc-L-Dap-OH serves as a starting material for the preparation of BIM analogs .

HY-139101

Guanosine 5'-triphosphate-5'-adenosine GpppA	Biochemical Assay Reagents
Guanosine 5'-triphosphate-5'-adenosine (GpppA), a 5′ cap analog, can be used for RNA synthesis in vitro. Guanosine 5'-triphosphate-5'-adenosine is a fluorescent substrate analog .

Cat. No.	Product Name		Classification

HY-131520

(E,E,E)-Farnesyl alcohol azide		Azide
(E,E,E)-Farnesyl alcohol azide can be used as a precursor for the preparation of C15-Azide analogs .

HY-77651

Nucleoside-Analog-1 1 Publications Verification		Azide
Nucleoside-Analog-1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Analog-1

Inhibitors & Agonists

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Biochemical Assay Reagents

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NaturalProducts

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