69909-92-8
69909-92-8
Chemical Structure
RNF5 agonist 1
- CAS No.: 69909-92-8
- Formula:C22H18N4S
- Molecular Weight:370.47
InChIKey: SCPUGCLDMPNDGZ-CFPQKXLCSA-N
SMILES: CC1=NS/C(N1C2=CC=CC=C2)=N\C(C3=CC=CC=C3)=N\C4=CC=CC=C4
Biological Activity: RNF5 agonist 1 (analog-1), a structural analog of RNF5 inhibitor inh-02 (HY-123967), is a potent RNF5 agonist. RNF5 agonist 1 increases the ubiquitylation status of ATG4B in F508del-CFTR-expressing CFBE41o- cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RNF5 agonist 1 | 99.05% | RNF5 agonist 1 (analog-1), a structural analog of RNF5 inhibitor inh-02 (HY-123967), is a potent RNF5 agonist. RNF5 agonist 1 increases the ubiquitylation status of ATG4B in F508del-CFTR-expressing CFBE41o- cells. | ||||||||||||||||||||
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References
- [1]. Sondo E, et al. Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia. Cell Chem Biol. 2018 Jul 19;25(7):891-905.e8. [Content Brief]
- [2]. Li Z, et al. The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation. Signal Transduct Target Ther. 2023 Feb 3;8(1):53. [Content Brief]
