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  3. Amino Acid Derivatives
  4. Boc-L-Dap-OH

Boc-L-Dap-OH is a Boc-protected derivative of L-2,3-diaminopropionic acid. Boc-L-Dap-OH is an important chiral amino acid derivative. Boc-L-Dap-OH can be generated via the Hofmann rearrangement of Boc-L-asparagine. Boc-L-Dap-OH serves as a starting material for the preparation of BIM analogs.

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Boc-L-Dap-OH

Boc-L-Dap-OH Chemical Structure

CAS No. : 73259-81-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Boc-L-Dap-OH Related Antibodies

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  • Purity & Documentation

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Description

Boc-L-Dap-OH is a Boc-protected derivative of L-2,3-diaminopropionic acid. Boc-L-Dap-OH is an important chiral amino acid derivative. Boc-L-Dap-OH can be generated via the Hofmann rearrangement of Boc-L-asparagine. Boc-L-Dap-OH serves as a starting material for the preparation of BIM analogs[1][2].

In Vitro

BIM compounds are a class of 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-based heterocyclic dipeptides, and are among the few known small-molecule tool compounds that can penetrate cell membranes and preferentially silence Gαq proteins. Their core representative molecules are the monomer BIM-46174 and its dimer BIM-46187 (HY-10499)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Boc-L-Dap-OH Related Antibodies
Molecular Weight

204.23

Formula

C8H16N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H](CN)NC(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (48.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8964 mL 24.4822 mL 48.9644 mL
5 mM 0.9793 mL 4.8964 mL 9.7929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.0% ee.: 99.85%

SDS (396 KB)

COA (248 KB) HNMR (133 KB) NP-HPLC (62 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8964 mL 24.4822 mL 48.9644 mL 122.4110 mL
5 mM 0.9793 mL 4.8964 mL 9.7929 mL 24.4822 mL
10 mM 0.4896 mL 2.4482 mL 4.8964 mL 12.2411 mL
15 mM 0.3264 mL 1.6321 mL 3.2643 mL 8.1607 mL
20 mM 0.2448 mL 1.2241 mL 2.4482 mL 6.1206 mL
25 mM 0.1959 mL 0.9793 mL 1.9586 mL 4.8964 mL
30 mM 0.1632 mL 0.8161 mL 1.6321 mL 4.0804 mL
40 mM 0.1224 mL 0.6121 mL 1.2241 mL 3.0603 mL
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Boc-L-Dap-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-L-Dap-OH73259-81-1Amino Acid Derivativeschiral amino acid derivativeHofmann rearrangementBoc-protected L-2,3-diaminopropionic acid derivativeBoc-L-AsnBIM analogsInhibitorinhibitorinhibit

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