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Results for "

Antithrombotic

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (32) Cardiovascular Disease (184) Endocrinology (6) Infection (10) Inflammation/Immunology (30) Metabolic Disease (17) Neurological Disease (8)
Oligonucleotides:	Aptamers (2) Emulsifiers (1) Solubilizing Agents (1) Polymers (2) Antisense Oligonucleotides (1)

216

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113527

TRIA-662 1-Methylnicotinamide chloride	Endogenous Metabolite	Metabolic Disease
TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities .

HY-17369B

Tirofiban 5+ Cited Publications L700462; MK383	Integrin	Cardiovascular Disease
Tirofiban (L700462) is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area .

HY-17459

Clopidogrel hydrogen sulfate Maximum Cited Publications 30 Publications Verification (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate	Cytochrome P450 P2Y Receptor	Cardiovascular Disease Cancer
Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC₅₀s of 18.2 nM and 524 nM, respectively . Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation ．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor .

HY-10268

Betrixaban 5 Publications Verification PRT054021	Factor Xa	Cardiovascular Disease
Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban shows antithrombotic effect .

HY-17369

Tirofiban hydrochloride monohydrate 5+ Cited Publications L700462 hydrochloride monohydrate; MK383 hydrochloride monohydrate	Integrin	Cardiovascular Disease
Tirofiban (L700462) hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban hydrochloride monohydrate induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban hydrochloride monohydrate can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area .

HY-100386

Ticlopidine 3 Publications Verification PCR 5332	NTPDase Cytochrome P450	Cardiovascular Disease
Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively.

HY-D1005H

Poloxamer 188 (F68) PEG-PPG-PEG, 8400(Average Mn)	Environmental Pollutants Biochemical Assay Reagents Fluorescent Dye	Others
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models .

HY-101312

Cilostamide 2 Publications Verification OPC3689	Phosphodiesterase (PDE)	Cardiovascular Disease
Cilostamide is a selective and potent PDE3 inhibitor, with IC₅₀s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.

HY-13831

BPTU 1 Publications Verification BMS-646786	P2Y Receptor	Neurological Disease Cancer
BPTU (BMS-646786) is a non-nucleotide P2Y₁ receptor allosteric antagonist with antithrombotic activity. BPTU is able to block the P2Y1 receptor located at the neuromuscular junction of the gastrointestinal tract .

HY-108660

PSB-0739 1 Publications Verification	P2Y Receptor	Cardiovascular Disease
PSB-0739 is a high-affinity potent, competitive, nonselective platelet P2Y₁₂ receptor antagonist with a K_i values of 24.9 nM. The P2Y₁₂ receptor plays a crucial role in platelet aggregation. Antithrombotic effect .

HY-B1271

Sulfinpyrazone 4 Publications Verification G-28315	Endogenous Metabolite	Inflammation/Immunology
Sulfinpyrazone (G-28315) is an orally active and potent uricosuric agent for chronic and intermittent gouty arthritis. Sulfinpyrazone has antithrombotic and platelet inhibitory effects .

HY-100897

Sulodexide	Thrombin	Cardiovascular Disease
Sulodexide is a mixture of glycosaminoglycans available in soft capsule form for oral administration. It is composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III (AT III) and heparin cofactor II (HC II), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease . Sulodexide is a glycosaminoglycan mixture available in soft gelatin capsule form for oral administration.

HY-N6864

Isovanillic acid 3-Hydroxy-4-methoxybenzoic acid	Thrombin	Cardiovascular Disease Metabolic Disease
Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) is a phenolic acid isolated from isolated from Scrophularia ningpoensis, with anti-thrombotic activity .

HY-15799

AZD1283	P2Y Receptor	Cardiovascular Disease
AZD1283 is a potent P2Y₁₂ receptor antagonist with a binding IC₅₀ of 11 nM and a GTPγS IC₅₀ of 25 nM. AZD1283 has excellent antiplatelet aggregation potency. AZD1283 can be used to research thromboembolic disorders .

HY-101054

NQ301 1 Publications Verification	Thrombin	Cardiovascular Disease
NQ301 is an antithrombotic agent; inhibits collagen-challenged rabbit platelet aggregation with an IC₅₀ of 10 mg/mL.

HY-118969

BMS-262084	Factor Xa Ser/Thr Protease	Cardiovascular Disease
BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC₅₀ of 2.8 nM against human factor XIa. BMS-262084 also inhibits human tryptase (IC₅₀=5 nM). BMS-262084 exhibits antithrombotic effects .

HY-156371

MIPS-21335	PI3K	Cardiovascular Disease Metabolic Disease
MIPS-21335 is a PI3KC2α inhibitor with an IC₅₀ of 7 nM. MIPS-21335 also inhibits PI3KC2β, p110α, p110β and p110δ, with IC₅₀ values of 43, 140, 386 and 742 nM, respectively. MIPS-21335 has antithrombotic effect. MIPS-21335 can be used for the researches of cardiovascular disease and metabolic disease, such as thrombosis and hyperlipidemia .

HY-100897A

Sulodexide solution	Thrombin	Cardiovascular Disease
Sulodexide solution is a mixture of glycosaminoglycans that can be administered by injection. It is composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III (AT III) and heparin cofactor II (HC II), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease.

HY-N5037

Ilexoside D	Others	Cardiovascular Disease
Ilexoside D is isolated from the roots of Ilex pubescens Hook. et Arn. Ilexoside D has the anti-tissue factor activity as well as the antithrombotic activity .

HY-N8903

Mumefural	Integrin NF-κB Toll-like Receptor (TLR) TNF Receptor	Cardiovascular Disease Neurological Disease
Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. Mumefural inhibits platelet aggregation. Mumefural shows anti-thrombotic effects and ameliorates cognitive impairment .

HY-109122

Selatogrel ACT-246475	P2Y Receptor	Cardiovascular Disease
Selatogrel (ACT-246475) is a reversible and selective P2Y₁₂ receptor antagonist which inhibits platelet aggregation with an IC₅₀ of 8 nM. Selatogrel exhibits antithrombotic efficacy .

HY-N2094

Genipin 1-β-D-gentiobioside 2 Publications Verification Genipin 1-gentiobioside; Genipin 1-β-gentiobioside; Genipin gentiobioside	Others	Inflammation/Immunology
Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) is one of the most abundant and bioactive iridoid glycosides in Gardenia jasminoides Ellis, which possesses hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.

HY-122098

Diaplasinin PAI-749	PAI-1	Cardiovascular Disease
Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC₅₀ of 295 nM. Diaplasinin has antithrombotic efficacy .

HY-124577

MDI-2268	PAI-1 Apoptosis	Cardiovascular Disease
MDI-2268 is an inhibitor of plasma kallikrein inhibitor 1 (PAI-1). MDI-2268 has good antithrombotic properties and regulates blood coagulation and fibrinolysis process by enhancing fibrinolysis. MDI-2268 can be used in research areas such as deep vein thrombosis .

HY-150790

BMS-986141	Protease Activated Receptor (PAR)	Cardiovascular Disease
BMS-98614 is an orally active, selective thrombin receptor protease-activated receptor-4 (PAR-4) antagonist with an IC₅₀ value of 0.4 nM. BMS-98614 has excellent antithrombotic effect .

HY-100386R

Ticlopidine (Standard) PCR 5332 (Standard)	Reference Standards NTPDase Cytochrome P450	Cardiovascular Disease
Ticlopidine (Standard) is the analytical standard of Ticlopidine. This product is intended for research and analytical applications. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively .

HY-N4271

Protogracillin	Others	Cardiovascular Disease
Protogracillin is a steroidal saponin isolated from Dioscorea zingiberensis Wright (DZW). Steroidal saponins from DZW rhizomes have the potential to reduce the risk of cardiovascular diseases by anti-thrombotic action .

HY-10268A

Betrixaban maleate 5 Publications Verification PRT054021 maleate	Factor Xa	Cardiovascular Disease
Betrixaban (PRT054021) maleate is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban maleate shows antithrombotic effect .

HY-106784

Ajoene	Fungal Apoptosis	Infection Cancer
Ajoene, a garlic-derived compound, is an *antithrombotic* and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities .

HY-105495

Iliparcil	Glycosyltransferase	Cardiovascular Disease
Iliparcil has a potent antithrombotic activity in the Wessler model in rats. Iliparcil has oral activity .

HY-10217

Thrombin Inhibitor 2	Thrombin	Cardiovascular Disease
Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor, extracted from US8541580B2. Thrombin Inhibitor 2 has antithrombotic activity .

HY-113527R

TRIA-662 (Standard) 1-Methylnicotinamide chloride (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
TRIA-662 (Standard) is the analytical standard of TRIA-662. This product is intended for research and analytical applications. TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities .

HY-B1271R

Sulfinpyrazone (Standard) G-28315 (Standard)	Reference Standards Endogenous Metabolite	Inflammation/Immunology
Sulfinpyrazone (Standard) is the analytical standard of Sulfinpyrazone. This product is intended for research and analytical applications. Sulfinpyrazone (G-28315) is an orally active and potent uricosuric agent for chronic and intermittent gouty arthritis. Sulfinpyrazone has antithrombotic and platelet inhibitory effects .

HY-P5875A

P4pal10 TFA	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
P4pal10 TFA is the TFA salt form of P4pal10 (HY-P5875). P4pal10 TFA is an antagonist for protease-activated receptor 4 (PAR4). P4pal10 TFA inhibits the platelet aggregation, inhibits tissue factor (TF)-induced thrombin generation, and exhibits anticoagulant and antithrombotic activities. P4pal10 TFA reduces the oedema and the granulocyte infiltration induced by Carrageenan (HY-125474). P4pal10 TFA ameliorates the injury in rats myocardial ischemia/reperfusion (I/R) models .

HY-W077219

Boc-L-Arg(Mtr)-OH Boc-Arg(Mtr)-OH	Amino Acid Derivatives	Others
Boc-L-Arg(Mtr)-OH (Boc-Arg(Mtr)-OH) is an amino acid derivative with a Boc protecting group, which can be used to synthesize peptides with antithrombotic activity .

HY-10268B

Betrixaban hydrochloride PRT054021 hydrochloride	Factor Xa	Cardiovascular Disease
Betrixaban (PRT054021) hydrochloride is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban hydrochloride shows antithrombotic effect .

HY-14853

Darexaban YM150	Factor Xa Ser/Thr Protease	Cardiovascular Disease
Darexaban (YM150) is a potent, selective and orally active factor Xa (FXa) inhibitor with an IC₅₀ of 54.6 nM. Darexaban shows high selectivity against other related serine proteases, such as trypsin, thrombin, and kallikrein. Darexaban has anticoagulant and antithrombotic effects .

HY-129496

NP-313	Thrombin	Cardiovascular Disease
NP-313 is a potent antithrombotic agent that inhibits platelet aggregation and activation. NP-313 has dual inhibition of thromboxane A 2 synthesis and selective inhibition of SOCC-mediated Ca ²⁺ inward flow .

HY-P99560

Tadocizumab C4G1; YM-337	Integrin	Cardiovascular Disease
Tadocizumab (C4G1; YM-337) is a humanized monoclonal antibody tageting integrin αIIbβ3. Tadocizumab has antiplatelet and antithrombotic effects, and can be used for cardiovascular disease research .

HY-U00383

Rafigrelide 3,3-Dimethylanagrelide	Thrombopoietin Receptor	Cardiovascular Disease
Rafigrelide is a platelet-lowering agent, and also has antithrombotic properties.

HY-107348

Etofylline clofibrate	Prostaglandin Receptor	Cardiovascular Disease
Etofylline clofibrate has ypolipidemic and antithrombotic effect. Etofylline clofibrate has an agonistic interaction with intimal PGI2 .

HY-147079A

Egaptivon pegol sodium ARC 1779 sodium	Integrin	Cardiovascular Disease
Egaptivon pegol sodium is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol sodium has anti-thrombotic efficacy.

HY-147079

Egaptivon pegol ARC 1779	Integrin	Cardiovascular Disease
Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.

HY-19373

RWJ-445167 3DP-10017	Thrombin Factor Xa	Cardiovascular Disease
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with K_i of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

HY-105559A

Viquidil hydrochloride Quinotoxine hydrochloride	Drug Isomer	Cardiovascular Disease
Viquidil hydrochloride (Quinotoxine hydrochloride), an isomer of Quinidine, is a cerebral vasodilator agent. Viquidil hydrochloride shows antithrombotic activity .

HY-105559

Viquidil Quinotoxine	Potassium Channel	Cardiovascular Disease
Viquidil (Quinotoxine), an isomer of Quinidine, is a cerebral vasodilator agent. Viquidil shows antithrombotic activity .

HY-W009418

TRIA-662 iodide 1-Methylnicotinamide iodide	Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
TRIA-662 (1-Methylnicotinamide chloride) iodide is an endogenous metabolite. TRIA-662 iodide shows antithrombotic and anti-inflammatory activities .

HY-125123

Euchrestaflavanone A	Integrin	Cardiovascular Disease
Euchrestaflavanone A is a flavonoid found in the root bark of Cudrania tricuspidate. Euchrestaflavanone A inhibits platelet aggregation and has some antiplatelet and antithrombotic properties, making it a potential compound for thromboprophylaxis .

HY-15759A

Napsagatran hydrate Ro 46-6240 hydrate; Ro 46-6240/010 hydrate	Thrombin	Cardiovascular Disease
Napsagatran (Ro 46-6240) hydrate is a potent thrombin inhibitor. Napsagatran hydrate exhibits anticoagulant effects in vitro and in vivo. Napsagatran hydrate can be used in antithrombotic research ^[1][2].

HY-163341

PAR4 antagonist 1	Protease Activated Receptor (PAR)	Cardiovascular Disease
PAR4 antagonist 1 (Compound 48) is a protease activated receptor 4 (PAR4) antagonist with an IC₅₀ of 1.8 nM. PAR4 antagonist 1 has an IC₅₀ of 2 nM against γ-thrombin-activated PAR4 in platelet-rich plasma (PRP). PAR4 antagonist 1 can be used in antithrombotic research .

Cat. No.	Product Name	Type

HY-D1005A

Poloxamer 188 PEG-PPG-PEG, 8800 (Average Mn)	Biochemical Assay Reagents
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models. Poloxamer 188 can be used for drug delivery .

HY-112624P

Dextran T500 (MW 500,000) 1 Publications Verification Dextran 500; Dextran D500; Dextran T500(MW 440000-560000)	Biochemical Assay Reagents
Dextran T500 MW 500,000 (Dextran 500; Dextran D500; Dextran T500 MW 440000-560000) is a polymer of anhydroglucose with the average molecular weight of 500,000. Dextran T500 MW 500,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .

HY-112624B

Dextran T70 (MW 70,000)

Dextran 70; Dextran D70; Dextran T70(MW 64000-76000)

Biochemical Assay Reagents

Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.

HY-D1005H

Poloxamer 188 (F68) PEG-PPG-PEG, 8400(Average Mn)	Biochemical Assay Reagents
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models .

HY-112624D

Dextran T60 (MW 60,000) Dextran 60; Dextran D60; Dextran T60(MW 54000-66000)	Biochemical Assay Reagents
Dextran T60 MW 60,000 (Dextran 60; Dextran D60; Dextran T60 MW 54000-66000) is a polymer of anhydroglucose with the average molecular weight of 60,000. Dextran T60 MW 60,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .

HY-112624Q

Dextran T800 (MW 800,000) Dextran 800; Dextran D800; Dextran T800(MW 750000-850000)	Biochemical Assay Reagents
Dextran T800 MW 800,000 (Dextran 800; Dextran D800; Dextran T800 MW 750000-850000) is a polymer of anhydroglucose with the average molecular weight of 800,000. Dextran T800 MW 800,000 exhibits good biodegradability and good biocompatibility, that is utilized in food, pharmaceutics, cosmetics, and research area .

Cat. No.	Product Name	Target	Research Area

HY-P2813

Hirudin 3 Publications Verification	Thrombin Apoptosis	Cardiovascular Disease Cancer
Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .

HY-122542B

PPACK TFA 2 Publications Verification	Ligands for E3 Ligase Molecular Glues IKZF Family	Cardiovascular Disease
PPACK TFA is an orally active, selective molecular glue degrader targeting IKZF2. Through a molecular glue mechanism, PPACK TFA binds to CRBN, recruits IKZF2 to form a ternary complex, and promotes its ubiquitination and proteasomal degradation. This further converts inhibitory regulatory T cells (T_reg) into effector-like T cells, enhances CD8 ⁺ T cell responses, and modulates the T_eff:T_reg balance. PPACK TFA also increases the production of the inflammatory cytokine IL-2 and reduces the suppressive activity of T_reg. PPACK TFA can be used in cancer immunotherapy research, and exhibits a synergistic effect when combined with immune checkpoint inhibitors such as anti-PD1 .

HY-132828

Odatroltide LT3001; DHDMIQK(KAP)	P-selectin	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Odatroltide (LT3001; DHDMIQK(KAP)) is a P-selectin inhibitor. Odatroltide is a peptide molecule comprising a tripeptide Pro-Ala-Lys (PAK) and an (S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid domain. Odatroltide can restore cerebral blood flow, scavenge free radicals, and inhibit leukocyte migration. Odatroltide possesses thrombolytic and anti-thrombotic activities .

HY-122542

PPACK	PAI-1 Thrombin	Inflammation/Immunology
PPACK is a potent, peptidic inhibitor targeting thrombin and granzyme GZMK. PPACK specifically blocks the activities of thrombin and GZMK, thereby inhibiting thrombin-mediated PAR-1 cleavage, as well as downstream inflammatory and procoagulant signaling pathways. Through stabilizing IκB proteins, blocking NF-κB activation and reducing systemic levels of proinflammatory/procoagulant biomarkers, PPACK exerts multiple effects including anti-inflammatory, antithrombotic, barrier repair, and inhibition of atherosclerotic plaque progression. PPACK binds to platelets without interference from kininogen, effectively limiting acute thrombus growth and reducing eosinophil infiltration and goblet cell hyperplasia in asthma models. PPACK is an important tool molecule for investigating the mechanisms of atherosclerosis, asthma and related thromboinflammatory diseases .

HY-P5875A

P4pal10 TFA	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
P4pal10 TFA is the TFA salt form of P4pal10 (HY-P5875). P4pal10 TFA is an antagonist for protease-activated receptor 4 (PAR4). P4pal10 TFA inhibits the platelet aggregation, inhibits tissue factor (TF)-induced thrombin generation, and exhibits anticoagulant and antithrombotic activities. P4pal10 TFA reduces the oedema and the granulocyte infiltration induced by Carrageenan (HY-125474). P4pal10 TFA ameliorates the injury in rats myocardial ischemia/reperfusion (I/R) models .

HY-W077219

Boc-L-Arg(Mtr)-OH Boc-Arg(Mtr)-OH	Amino Acid Derivatives	Others
Boc-L-Arg(Mtr)-OH (Boc-Arg(Mtr)-OH) is an amino acid derivative with a Boc protecting group, which can be used to synthesize peptides with antithrombotic activity .

HY-P5889

Thrombin receptor peptide ligand	Thrombin	Cardiovascular Disease
Thrombin receptor peptide ligand is a thrombin receptor antagonist peptide that can be used as an antithrombotic agent .

HY-P10949

pep-10L peptide	Glycoprotein VI	Cardiovascular Disease
Pep-10L peptide is a glycoprotein VI (GPVI) antagonist with K_i values of 180, 225, and 179 μM for CPR, GPO-1, and Type 1 collagen, respectively. Pep-10L peptide has anti-thrombotic effects .

HY-105240

Delparantag PMX-60056	Factor Xa	Cardiovascular Disease
Delparantag (PMX-60056) is a salicylamide derivative and an effective unfractionated heparin (UFH) and low molecular weight heparin (LMWH) reversing agent. Delparantag shows ability to neutralize the anticoagulation and bleeding effects of UFH and LMWH .

HY-P3082

SKF 106760	Endogenous Metabolite	Cardiovascular Disease
SKF 106760 is a potent platelet fibrin receptor (glycoprotein IIb/IIIa) antagonist with significant antiplatelet and antithrombotic activities. SKF 106760 inhibits platelet aggregation in dogs in vitro and prevents thrombus formation in stenotic carotid arteries. SKF 106760 has also shown elimination effects against aspirin-resistant thrombi that develop in the setting of high-grade stenosis .

HY-P5875

P4pal10	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
P4pal10 is an antagonist for protease-activated receptor 4 (PAR4). P4pal10 inhibits the platelet aggregation, inhibits tissue factor (TF)-induced thrombin generation, and exhibits anticoagulant and antithrombotic activities. P4pal10 reduces the oedema and the granulocyte infiltration induced by Carrageenan (HY-125474). P4pal10 ameliorates the injury in mice myocardial ischemia/reperfusion (I/R) models .

HY-P4721

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) sulfated	Thrombin	Cardiovascular Disease
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a K_D < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM .

HY-P1711

L 366763	Peptides	Cardiovascular Disease
L 366763 is a potent peptide that acts as a fibrinogen receptor antagonist, preventing collagen-induced platelet aggregation and adhesion. L 366763 inhibits platelet deposition and maintains blood flow in a baboon thrombosis model, significantly prolonging bleeding time. L 366763 has antithrombotic efficacy, whereas recombinant LAPP does not have the same effect .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99560

Tadocizumab C4G1; YM-337	Integrin	Cardiovascular Disease
Tadocizumab (C4G1; YM-337) is a humanized monoclonal antibody tageting integrin αIIbβ3. Tadocizumab has antiplatelet and antithrombotic effects, and can be used for cardiovascular disease research .

HY-P991516

TB-402	Factor VIII	Cardiovascular Disease
TB-402, a human IgG4 anticoagulant monoclonal antibody, is a partial Factor VIII inhibitor. TB-402 has a prolonged antithrombotic effect. TB-402 can be used for the prevention of venous thromboembolism (VTE) after total knee replacement (TKR) .

HY-P991993

AB054	Factor Xa	Cardiovascular Disease
AB054 is a humanized monoclonal antibody targeting factor XII (FXII). AB054 inhibits FXII activation and FXIIa activity through specific binding to the catalytic domain of FXII, and exerts antithrombotic effects in a concentration-dependent manner. AB054 can be used in studies related to thrombosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113527

TRIA-662 1-Methylnicotinamide chloride	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities .

HY-N0188

Esculin 5 Publications Verification	Structural Classification Monophenols other families Classification of Application Fields Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	p38 MAPK
Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

HY-P2813

Hirudin 3 Publications Verification	Cardiovascular Disease Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification Cancer	Thrombin Apoptosis
Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .

HY-P2970

Stem bromelain	Ananas comosus(L.) Merr. Structural Classification Natural Products Classification of Application Fields Bromeliaceae Plants Inflammation/Immunology Disease Research Fields Cancer	Apoptosis PARP Caspase Bcl-2 Family Bacterial Interleukin Related
Stem bromelain (EC 3.4.22.32) is a cysteine protease and antibacterial agent. Stem bromelain can be isolated from the stem of the pineapple (Ananas comosus). Stem bromelain induces dose-dependent secretion of IL-12p70, and IL-6, induces Apoptosis, causes cleavage of full-length PARP protein, Caspase 3, and Caspase 9, increases Bax, and decreases Bcl-2. Stem bromelain possesses various fibrinolytic, antiedema, antithrombotic, and anti-inflammatory activities. Stem bromelain also exhibits in vivo antitumor and antileukemic activities, as well as antimetastatic effects. Stem bromelain has antimycobacterial activity. Stem bromelain provides protection against lead poisoning .

HY-B1271

Sulfinpyrazone 4 Publications Verification G-28315	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Sulfinpyrazone (G-28315) is an orally active and potent uricosuric agent for chronic and intermittent gouty arthritis. Sulfinpyrazone has antithrombotic and platelet inhibitory effects .

HY-124124

N-Methylnicotinamide 1 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Metabolite
N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway .

HY-N0496

Ruscogenin Maximum Cited Publications 6 Publications Verification	Ophiopogon japonicus (L. f.) Ker-Gawl. Cardiovascular Disease Liliaceae Classification of Application Fields Plants Disease Research Fields Steroids Source Classification	NOD-like Receptor (NLR)
Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity .

HY-N8278

Dermatan sulphate sodium 1 Publications Verification	Natural Products Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Thrombin
Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin (HY-108345). Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation .

HY-N6864

Isovanillic acid 3-Hydroxy-4-methoxybenzoic acid	Monophenols Classification of Application Fields Scrophularia ningpoensis Hemsl. Ketones, Aldehydes, Acids Phenols Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Thrombin
Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) is a phenolic acid isolated from isolated from Scrophularia ningpoensis, with anti-thrombotic activity .

HY-N0367

Trans-Anethole 2 Publications Verification (E)-Anethole	Structural Classification Classification of Application Fields Simple Phenylpropanols Phenylpropanoids Umbelliferae Plants Endogenous metabolite Vernonia Schreb. Disease Research Fields Source Classification Cancer	Environmental Pollutants Endogenous Metabolite
Trans-Anethole ((E)-Anethole) is an orally active phenylpropene derivative found in Foeniculum vulgare that is estrogenic at low concentrations and cytotoxic at high concentrations in tumor cell lines. Trans-Anethole also has anti-aflatoxin, anti-thrombotic and anti-diabetic activities. Trans-Anethole is an important odor component in plants such as fennel, myrtle, liquorice, and camphor .

HY-113439

12-HETE 2 Publications Verification	Microorganisms Source Classification	Apoptosis
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

HY-N0713

Diosmetin-7-O-β-D-glucopyranoside	Flavonoids Classification of Application Fields Flavones Dendranthema morifolium (Ramat.) Tzvel. Other Diseases Phenols Polyphenols Plants Compositae Disease Research Fields Source Classification	SARS-CoV NF-κB Interleukin Related
Diosmetin-7-O-β-D-glucopyranoside is a natural product that can be isolated from the flowers of Chrysanthemum morifolium. Diosmetin-7-O-β-D-glucopyranoside has potent antiviral and anti-inflammatory activities against SARS-CoV-2 both in vitro (IC₅₀ = 0.74 μM) and in vivo. Diosmetin-7-O-β-D-glucopyranoside has significant anti-thrombotic activity when combined with Pae and 5-HMF at a ratio of 3:4:3 in a zebrafish model .

HY-N3097

Pellitorine	Alkaloids Classification of Application Fields Other Alkaloids Piperaceae Plants Disease Research Fields Piper nigrum Linn. Biological Pesticide Research Source Classification Cancer Agricultural Research	TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB ERK Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial
Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria .

HY-N0677

Dehydroandrographolide succinate 1 Publications Verification	Acanthaceae Classification of Application Fields Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification Cancer	Influenza Virus Prostaglandin Receptor Akt GSK-3
Dehydroandrographolide succinate can be extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used in research for viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect. Dehydroandrographolide succinate exerts antithrombotic effect. Dehydroandrographolide succinate significantly inhibits the platelet aggregation rate (ED₅₀ = 386.9 mg/kg) by decreasing TXB₂ levels. Dehydroandrographolide succinate mitigates muscle astrophy via the Akt/GSK3β and MuRF-1 pathways .

HY-N5037

Ilexoside D	Cardiovascular Disease Aquifoliaceae Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Tabernaemontana elegans Stapf Source Classification	Others
Ilexoside D is isolated from the roots of Ilex pubescens Hook. et Arn. Ilexoside D has the anti-tissue factor activity as well as the antithrombotic activity .

HY-N2094

Genipin 1-β-D-gentiobioside 2 Publications Verification Genipin 1-gentiobioside; Genipin 1-β-gentiobioside; Genipin gentiobioside	Iridoids Classification of Application Fields Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields Source Classification	Others
Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) is one of the most abundant and bioactive iridoid glycosides in Gardenia jasminoides Ellis, which possesses hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.

HY-N1400

(20R)-Ginsenoside Rh1	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification Cancer	PKC
(20R)-Ginsenoside Rh1 is the R-isomer of Ginsenoside Rh1 (HY-N0604), and it is found in red ginseng, ginseng, and other sources. (20R)-Ginsenoside Rh1 inhibits thrombin-induced conversion of fibrinogen to fibrin, exerting anticoagulant and antithrombotic effects .

HY-N1745A

3-Deoxysappanchalcone 2 Publications Verification	Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Influenza Virus
3-Deoxysappanchalcone is a kinase inhibitor and antiviral agent. 3-Deoxysappanchalcone directly targets MET, EGFR, AKT, mTOR, p38 MAPK, JNK, thrombin, FXa, and influenza virus neuraminidase, thereby regulating related signaling pathways. 3-Deoxysappanchalcone induces cell cycle arrest, ROS production, and apoptosis. 3-Deoxysappanchalcone exhibits anti-inflammatory, anti-allergic, anticoagulant, and antithrombotic activities. 3-Deoxysappanchalcone is applicable to research related to gefitinib-resistant lung cancer, esophageal squamous cell carcinoma, thrombosis, and influenza virus infection .

HY-N4271

Protogracillin	Cardiovascular Disease other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification	Others
Protogracillin is a steroidal saponin isolated from Dioscorea zingiberensis Wright (DZW). Steroidal saponins from DZW rhizomes have the potential to reduce the risk of cardiovascular diseases by anti-thrombotic action .

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Cardiovascular Disease Flavonols Flavonoids Typhaceae Classification of Application Fields Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields Source Classification	Thrombin COX ERK JNK Factor Xa
Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases .

HY-106784

Ajoene	Infection Natural Products Liliaceae Classification of Application Fields Plants Disease Research Fields A．Sativam L. var．Viviparum Regel Source Classification	Fungal Apoptosis
Ajoene, a garlic-derived compound, is an *antithrombotic* and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities .

HY-113527R

TRIA-662 (Standard) 1-Methylnicotinamide chloride (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
TRIA-662 (Standard) is the analytical standard of TRIA-662. This product is intended for research and analytical applications. TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities .

HY-B1271R

Sulfinpyrazone (Standard) G-28315 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Sulfinpyrazone (Standard) is the analytical standard of Sulfinpyrazone. This product is intended for research and analytical applications. Sulfinpyrazone (G-28315) is an orally active and potent uricosuric agent for chronic and intermittent gouty arthritis. Sulfinpyrazone has antithrombotic and platelet inhibitory effects .

HY-N0188R

Esculin (Standard)	Structural Classification Monophenols other families Coumarins Phenols Phenylpropanoids Plants Source Classification	Reference Standards p38 MAPK
Esculin (Standard) is the analytical standard of Esculin. This product is intended for research and analytical applications. Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

HY-125123

Euchrestaflavanone A	Flavonoids Flavones Leguminosae Sophora alopecuroides L Plants Source Classification	Integrin
Euchrestaflavanone A is a flavonoid found in the root bark of Cudrania tricuspidate. Euchrestaflavanone A inhibits platelet aggregation and has some antiplatelet and antithrombotic properties, making it a potential compound for thromboprophylaxis .

HY-N7314

Asebogenin	Glycosmis parviflora Kurz. Phenols Polyphenols Plants Salicaceae Source Classification	Syk
Asebogenin has antimalarial activity in vitro . Asebogenin can inhibit the phosphorylation of Syk, thereby effectively suppressing platelet activation and the formation of neutrophil extracellular traps .

HY-N0496R

Ruscogenin (Standard)	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Liliaceae Plants Steroids Source Classification	Reference Standards NOD-like Receptor (NLR)
Ruscogenin (Standard) is the analytical standard of Ruscogenin. This product is intended for research and analytical applications. Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity .

HY-N6864R

Isovanillic acid (Standard) 3-Hydroxy-4-methoxybenzoic acid (Standard)	Structural Classification Monophenols Scrophularia ningpoensis Hemsl. Ketones, Aldehydes, Acids Phenols Scrophulariaceae Plants Source Classification	Reference Standards Thrombin
Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) is a phenolic acid isolated from isolated from Scrophularia ningpoensis, with anti-thrombotic activity .

HY-N16369

1,2-Di-(9Z-hexadecenoyl)-sn-glycerol	Microorganisms Antibiotics Other Antibiotics Source Classification	Thrombin
1,2-Di-(9Z-hexadecenoyl)-sn-glycerol (Compound 2e) is a diacylglycerol derivative that can be isolated from the fungus Stereum Hirsutum. 1,2-Di-(9Z-hexadecenoyl)-sn-glycerol has potential thrombin-inhibiting activity and can be used in research related to antithrombotic drugs .

HY-124124R

N-Methylnicotinamide (Standard)	Alkaloids Structural Classification Pyridine Alkaloids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Drug Metabolite
N-Methylnicotinamide (Standard) is the analytical standard of N-Methylnicotinamide (HY-124124). This product is intended for research and analytical applications. N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway.

HY-N0367R

Trans-Anethole (Standard) (E)-Anethole (Standard)	Structural Classification Simple Phenylpropanols Phenylpropanoids Umbelliferae Plants Endogenous metabolite Vernonia Schreb. Source Classification	Reference Standards Endogenous Metabolite
Trans-Anethole (Standard) is the analytical standard of Trans-Anethole. This product is intended for research and analytical applications. Trans-Anethole ((E)-Anethole) is an orally active phenylpropene derivative found in Foeniculum vulgare that is estrogenic at low concentrations and cytotoxic at high concentrations in tumor cell lines. Trans-Anethole also has anti-aflatoxin, anti-thrombotic and anti-diabetic activities. Trans-Anethole is an important odor component in plants such as fennel, myrtle, liquorice, and camphor .

HY-N1400R

(20R)-Ginsenoside Rh1 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Plants Araliaceae Source Classification	Reference Standards PKC
(20R)-Ginsenoside Rh1 (Standard) is the analytical standard of (20R)-Ginsenoside Rh1 (HY-N1400). This product is intended for research and analytical applications. (20R)-Ginsenoside Rh1 is the R-isomer of Ginsenoside Rh1 (HY-N0604), and it is found in red ginseng, ginseng, and other sources. (20R)-Ginsenoside Rh1 inhibits thrombin-induced conversion of fibrinogen to fibrin, exerting anticoagulant and antithrombotic effects .

HY-N3097R

Pellitorine (Standard)	Alkaloids Other Alkaloids Piperaceae Plants Piper nigrum Linn. Source Classification	Reference Standards TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial
Pellitorine (Standard) is the analytical standard of Pellitorine (HY-N3097). Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria.

HY-N17611

5,6,7-Trihydroxy-4'-methoxyflavone 4'-O-Methylscutellarein	Structural Classification Flavonoids Flavones Labiatae Plants Medicago truncatula Gaertn. Source Classification	Xanthine Oxidase
5,6,7-Trihydroxy-4'-methoxyflavone (4'-O-Methylscutellarein) is a flavonoid and a weak inhibitor of xanthine oxidase. 5,6,7-Trihydroxy-4'-methoxyflavone possesses antithrombotic and antioxidant activities. 5,6,7-Trihydroxy-4'-methoxyflavone has an IC₅₀ value of 25.29 µM for DPPH free radical scavenging. 5,6,7-Trihydroxy-4'-methoxyflavone can also inhibit H₂O₂-induced damage to PC12 cells. 5,6,7-Trihydroxy-4'-methoxyflavone is applicable for the research of diseases such as cerebrovascular disorders .

HY-N2094R

Genipin 1-β-D-gentiobioside (Standard) Genipin 1-gentiobioside (Standard); Genipin 1-β-gentiobioside (Standard); Genipin gentiobioside (Standard)	Structural Classification Iridoids Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis Source Classification	Reference Standards Others
Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) is one of the most abundant and bioactive iridoid glycosides in Gardenia jasminoides Ellis, which possesses hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.

HY-W835723

1-(2,6-Dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one	Structural Classification Monophenols Phenols Plants Asparagaceae Juss. Source Classification	Drug Derivative
1-(2,6-Dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one is a phenolic compound derived from Dracaena cochinchinensis that exhibits antioxidant, antimicrobial, antiviral, hemostatic, antithrombotic, anti-inflammatory activities, and protects myocardial cells .

HY-N16748

Heptazoline	Structural Classification Alkaloids Rutaceae Carbazole Alkaloids Plants Clausena excavata N. L. Burman Source Classification	Others
Heptazoline is a carbazole alkaloid that can be isolated from the stem bark of Clausena excavata. Heptazoline exhibits significant antiplatelet aggregation activity (inhibiting platelet aggregation induced by arachidonic acid, collagen, etc.) and certain vasodilatory activity (inhibiting norepinephrine-induced contraction of rat aorta). Heptazoline can be used in antithrombotic research in the cardiovascular field .

Cat. No.	Product Name	Chemical Structure

HY-113439S

12-HETE-d8 2 Publications Verification
12-HETE-d₈ is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

HY-113527S

TRIA-662-d3
TRIA-662-d₃ is the deuterium labeled TRIA-662 . TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities .

HY-124124S

N-Methylnicotinamide-d4

N-Methylnicotinamide-d₄ is the deuterium labeled N-Methylnicotinamide (HY-124124). N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway.

HY-10264S

Edoxaban-d6

Edoxaban-d₆ is deuterium labeled Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention. Edoxaban is also a weak inhibitor of thrombin and factor IXaβ (FIXa), with Kis of 6.00 μM and 41.7 μM, respectively, exhibits >10000-fold selectivity for FXa. Edoxaban has antithrombotic properties and has potential for thromboembolic diseases treatment .

HY-10268S1

Betrixaban-d4
Betrixaban-d₄ (PRT054021-d₄) is deuterium labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban shows antithrombotic effect .

HY-N0367S

Trans-Anethole-d3

Trans-Anethole-d3 is deuterated labeled Trans-Anethole (HY-N0367). Trans-Anethole ((E)-Anethole) is an orally active phenylpropene derivative found in Foeniculum vulgare that is estrogenic at low concentrations and cytotoxic at high concentrations in tumor cell lines. Trans-Anethole also has anti-aflatoxin, anti-thrombotic and anti-diabetic activities. Trans-Anethole is an important odor component in plants such as fennel, myrtle, liquorice, and camphor .

HY-100386S

Ticlopidine-d4

Ticlopidine-d₄ is the deuterium labeled Ticlopidine. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively .

HY-17459S

Clopidogrel-d3 hydrogen sulfate

Clopidogrel-d₃ (hydrogen sulfate) is the deuterium labeled Clopidogrel hydrogen sulfate . Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC₅₀s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor .

HY-B0153AS

Ticlopidine-d4 hydrochloride

Ticlopidine-d₄ hydrochloride is the deuterium labeled Ticlopidine hydrochloride (HY-B0153A). Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively .

HY-W707554

Ticlopidine hydrochloride-d6

Ticlopidine hydrochloride-d₆ is the deuterium labeled Ticlopidine hydrochloride (HY-B0153A). Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively .

HY-10268S2

Betrixaban-13C6
Betrixaban- ¹³C₆ (PRT054021- ¹³C₆) is ¹³C labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC₅₀ of 1.5 nM. Betrixaban shows antithrombotic effect .

HY-166530S

Ticlopidine-d6 hydrochloride

Ticlopidine-d₆ hydrochloride is the deuterium labeled Ticlopidine hydrochloride. Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC₅₀ of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC₅₀s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively . Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC₅₀s of 26.0 and 32.3 μM, respectively .

Cat. No.	Product Name		Classification

HY-D1005A

Poloxamer 188 PEG-PPG-PEG, 8800 (Average Mn)		Emulsifiers Solubilizing Agents
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models. Poloxamer 188 can be used for drug delivery .

HY-112624B

Dextran T70 (MW 70,000) Dextran 70; Dextran D70; Dextran T70(MW 64000-76000)		Polymers
Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.

HY-D1005H

Poloxamer 188 (F68) PEG-PPG-PEG, 8400(Average Mn)		Polymers
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models .

HY-108746

Defibrotide sodium		Antisense Oligonucleotides
Defibrotide sodium is a complex mixture of single stranded polydeoxyribonucleotides. Defibrotide sodium has liver protection, anti-inflammatory, antithrombotic, profibrinolytic, and anti-ischemic properties. Defibrotide sodium can be used for sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) research .

HY-147079A

Egaptivon pegol sodium ARC 1779 sodium		Aptamers
Egaptivon pegol sodium is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol sodium has anti-thrombotic efficacy.

HY-147079

Egaptivon pegol ARC 1779		Aptamers
Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.

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