870544-59-5
870544-59-5
Chemical Structure
BPTU
Synonym(s): BMS-646786
- CAS No.: 870544-59-5
- Formula:C23H22F3N3O3
- Molecular Weight:445.43
IUPAC Name: 1-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea
InChIKey: AHFLGPTXSIRAQK-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2=CC=CN=C2OC3=CC=CC=C3C(C)(C)C
Biological Activity: BPTU (BMS-646786) is a non-nucleotide P2Y1 receptor allosteric antagonist with antithrombotic activity. BPTU is able to block the P2Y1 receptor located at the neuromuscular junction of the gastrointestinal tract[1][2].
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BPTU | 99.67% | BPTU (BMS-646786) is a non-nucleotide P2Y1 receptor allosteric antagonist with antithrombotic activity. BPTU is able to block the P2Y1 receptor located at the neuromuscular junction of the gastrointestinal tract. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.87
HY-124405P2Y1 antagonist 6 -
Similarity Score 0.57
HY-160676sEH-IN-1 -
Similarity Score 0.55
HY-151463CDK8-IN-11 -
Similarity Score 0.55
HY-18817AFG210 -
Similarity Score 0.53
HY-145887BCR-ABL1-IN-1 -
Similarity Score 0.53
HY-136658STAT3-IN-48 -
Similarity Score 0.52
HY-143491VS 8 -
Similarity Score 0.52
HY-B2049RTriflumuron (Standard) -
Similarity Score 0.52
HY-136657SC-43 -
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References
- [1]. Noemí Mañé, et al. BPTU, an allosteric antagonist of P2Y1 receptor, blocks nerve mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents. Neuropharmacology. 2016 Nov;110(Pt A):376-385. [Content Brief]
- [2]. Dandan Zhang, et al. Two disparate ligand binding sites in the human P2Y1 receptor. Nature. 2015 Apr 16; 520(7547): 317–321. [Content Brief]
