472-11-7
Chemical Structure
Ruscogenin
- CAS. Nr.: 472-11-7
- Formula:C27H42O4
- Molecular Weight:430.62
IUPAC Name: (4R,5'R,6R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4,6-diol
InChIKey: QMQIQBOGXYYATH-IDABPMKMSA-N
SMILES: C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])C[C@@]1([H])[C@@](CC=C(C[C@@H](O)C5)[C@@]6([C@@H]5O)C)([H])[C@]6([H])CC2
Biological Activity: Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Ruscogenin | 99.85% | Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity. | ||||||||||||||||||||
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Ruscogenin (Standard) | ≥98% | Ruscogenin (Standard) is the analytical standard of Ruscogenin. This product is intended for research and analytical applications. Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity. | ||||||||||||||||||||
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Similarity Score 1.00
HY-N17945(25S)-Ruscogenin -
Similarity Score 1.00
HY-N513625(R,S)-Ruscogenin -
Similarity Score 0.86
HY-N2253Neoruscogenin -
Similarity Score 0.84
HY-N0177Diosgenin -
Similarity Score 0.84
HY-N2078RYamogenin (Standard) -
Similarity Score 0.74
HY-N1317725(S)Ruscogenin 3-O-α-L-rhamnopyranoside -
Similarity Score 0.74
HY-121593Ruizgenin -
Similarity Score 0.74
HY-N10451Chlorogenin -
Similarity Score 0.74
HY-N16989Neochlorogenin -
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References
- [1]. Cao G, et al. Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. Int J Mol Sci. 2016 Aug 29;17(9). pii: E1418. [Content Brief]
- [2]. Huang YL, et al. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB. J Pharmacol Sci. 2008 Oct;108(2):198-205. [Content Brief]
