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Results for "

BB2

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

5

Peptides

9

Recombinant Proteins

4

Antibodies

2

Oligonucleotides

Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-103286
    PD176252
    2 Publications Verification

    		 Bombesin Receptor Cancer
    PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.
    PD176252
  • HY-162142
    BB2-50F

    		Bacterial Succinate Dehydrogenase Reactive Oxygen Species (ROS) Infection
    BB2-50F is an antimicrobial agent and succinate dehydrogenase and F1Fo-ATP synthase inhibitor. BB2-50F induces ROS. BB2-50F inhibits succinate oxidation and reduces tricarboxylic acid (TCA) cycle activity. BB2-50F inhibits the growth of Mycobacterium tuberculosis H37Rv and its auxotrophic, attenuated derivative mc2 6230 (ΔRD1, ΔpanCD) with an MIC of 8 μM .
    BB2-50F
  • HY-116216
    PD 168368

    		Bombesin Receptor Cancer
    PD 168368 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with the Ki of 15–45 nM . PD 168368 is neuromedin B receptor (NMBR; IC50=96 nM) / gastrin-releasing peptide receptor (GRPR IC50=3500 nM) antagonist [2]. PD 168368 also is a mixed FPR1/FPR2/FPR3 agonist with EC50s of 0.57, 0.24, and 2.7 nM, respectively .
    PD 168368
  • HY-P10896
    NOTA-P2-RM26

    		Bombesin Receptor Cancer
    NOTA-P2-RM26 is an antagonist of Bombesin (HY-P0195) analogs, and the gastrin-releasing peptide receptor (GRPR/BB2) is a molecular target for prostate cancer visualization. NOTA-P2-RM26 is labeled with 111In and 68Ga for prostate cancer imaging studies using PET and SPECT/CT .
    NOTA-P2-RM26
  • HY-103277
    BIM 23042

    		Bombesin Receptor Neurological Disease Metabolic Disease
    BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin?B?(HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca 2+ release [2] .
    BIM 23042
  • HY-103277A
    BIM 23042 TFA
    1 Publications Verification

    		 Bombesin Receptor Neurological Disease Metabolic Disease
    BIM 23042 TFA, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin?B?(HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca 2+ release [2] .
    BIM 23042 TFA
  • HY-103286R
    PD176252 (Standard)

    		Reference Standards Bombesin Receptor Cancer
    PD176252 (Standard) is the analytical standard of PD176252 (HY-103286). This product is intended for research and analytical applications. PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.
    PD176252 (Standard)
  • HY-P11768
    AMBA

    		Bombesin Receptor Cancer
    AMBA is a gastrin-releasing peptide receptor (GRPR, BB2, BRS-2) ligand with a human IC50 of 0.82 nM and a human Ki of 0.65 nM. AMBA binds to GRPR with high specificity and high affinity, and undergoes receptor-mediated endocytosis, which retains the conjugated radiometal in target cells. AMBA is applicable for the research of prostate cancer .
    AMBA
  • HY-RS05847
    GRPR Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    GRPR Human Pre-designed siRNA Set A contains three designed siRNAs for GRPR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GRPR Human Pre-designed siRNA Set A
    GRPR Human Pre-designed siRNA Set A
  • HY-RS06512
    ICAM1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ICAM1 Human Pre-designed siRNA Set A contains three designed siRNAs for ICAM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ICAM1 Human Pre-designed siRNA Set A
    ICAM1 Human Pre-designed siRNA Set A
  • HY-P11408
    [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14)

    		Bombesin Receptor Neurological Disease Cancer
    [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14), a synthetic peptide, is a non-selective bombesin receptor agonist. [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14) has preferred pEC50 values of 8.06 for the neurotrophin B bombesin receptor (BB1), 8.69 for the gastrin-releasing peptide bombesin receptor (BB2), and 6.71 for the orphan receptor (BB3). [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14) can be used to study diseases related to bombesin receptors, such as cancer and neurological disorders .
    [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14)
  • HY-17673
    PD 168368 derivative-1

    		Drug Derivative Bombesin Receptor Neurological Disease Cancer
    PD 168368 derivative-1 (Compound 16) is a derivative of PD 168368 (HY-116216), with Ki values of 0.46 and 3.7 nM for the subtypes of bombesin receptor (BB₁ and BB₂). PD 168368 derivative-1 can be used for the study of various diseases, such as cancer, depression, and eating disorders .
    PD 168368 derivative-1

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