ICAM1/CD54 Antibody (YA3656)

Cat. No.: HY-P83959: Ficha de datos User Guide for Antibodies
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ICAM1/CD54 Antibody (YA3656) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ICAM1/CD54.

Para uso exclusivo en investigación. No vendemos a pacientes.

Tamaño	Stock	Cantidad
20 μL	Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn
Referencias

Descripciòn

ICAM1/CD54 Antibody (YA3656) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ICAM1/CD54.

Host

Rabbit

Clonality

Monoclonal

Peso molecular

Predicted band size: 60 kDa;

Observed band size: 120 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Mouse

SwissProt ID

P13597

Immunogen

Recombinant protein within mouse ICAM1 aa 1-485.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:10,000
IHC-F IHC-F: Immunohistochemistry-Frozen	1:1,000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:2,000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200
FC FC: Flow Cytometry	1:2,000
IP IP: Immunoprecipitation	1-2μg/sample
IF-Tissue IF-Tissue: Immunofluorescence-Tissue	1:500

Pureza	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation; (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins; (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins; (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell

Subcellular Localization：Membrane; Single-pass type I membrane protein

Expression：
Induction:Up-regulated by coagulation factor Xa (F10) in atrial tissues (PubMed:24041930) . Up-regulated in atrial tissues by rapid pacing resembling atrial fibrillation (PubMed:24041930)

Subunit：Homodimer (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells

Synonyms

BB2; CD54; P3.58

Documentación

User Guide for Antibodies (1077 KB)

Referencias

[1]. /biology-dictionary/pc-3-cell.html [Content Brief]