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CAGE

" in MedChemExpress (MCE) Product Catalog:

57

Inhibitors & Agonists

2

Fluorescent Dye

3

Peptides

1

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9

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1

Isotope-Labeled Compounds

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108786
    Asfotase alfa

    ENB-0040

    		 Phosphatase Metabolic Disease
    Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2 / knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP) .
    Asfotase alfa
  • HY-P10761
    DPI-4452

    		Radionuclide-Drug Conjugates (RDCs) Carbonic Anhydrase Cancer
    DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC50 for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models . DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    DPI-4452
  • HY-N2427
    Adamantane

    		Others Others
    Adamantane is a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be studied in pharmacological research to improve the lipophilicity and pharmacological properties of other active products .
    Adamantane
  • HY-107520
    MNI-caged-L-glutamate

    		Drug Derivative Neurological Disease
    MNI-caged-L-glutamate is an inert photolabile glutamate precursor. MNI-caged-L-glutamate does not modulate NMDA and AMPA receptor function in cultured neurones. MNI-caged-L-glutamate can be used for research on neurotransmitters .
    MNI-caged-L-glutamate
  • HY-136276
    DMNB-caged-Serine

    		Amino Acid Derivatives Others
    DMNB-caged-Serine is a photocaged amino acid. DMNB-caged-Serine can be used as a catalytic residue, hydrogen bonding partner or site of post-translational modification. DMNB-caged-Serine can be used for the control of protein phosphorylation .
    DMNB-caged-Serine
  • HY-168992
    UNC6535

    		Histone Methyltransferase Neurological Disease Cancer
    UNC6535 is a covalent ligand targeting the SETDB1 triple Tudor domain (3TD) with negative allosteric modulator properties, with an IC50 of 3.4 μM and a Kd of 4.2 μM. UNC6535 inhibits the methyltransferase activity of recombinant SETDB1 protein lacking the 3TD domain. UNC6535 reversibly binds to the aromatic cages of both TD2 and TD3 subdomains of SETDB1 3TD simultaneously, displacing the endogenous H3K9Me2K14Ac histone tail ligand. UNC6535 can be used in research on cancer and neurodegenerative diseases .
    UNC6535
  • HY-156906
    UNC3474

    		MDM-2/p53 Cancer
    UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1 TT, with a dissociation constant (Kd) of 1.0 ± 0.3 μM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells .
    UNC3474
  • HY-153890
    NVOC cage-TMP-Halo

    		Biochemical Assay Reagents Others
    NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research .
    NVOC cage-TMP-Halo
  • HY-126789
    DM-Nitrophen

    		Biochemical Assay Reagents Metabolic Disease
    DM-Nitrophen is a photolabile caged calcium compound that acts as a calcium releaser. DM-Nitrophen binds Ca 2+ with high affinity and Mg 2+ with considerable affinity before photolysis. DM-Nitrophen releases Ca 2+ into the cytosol upon ultraviolet light irradiation. DM-Nitrophen induces calcium concentration pulses, triggers cytosolic calcium transients, promotes calcium-dependent exocytosis. DM-Nitrophen can be used for the research of calcium-dependent cellular processes .
    DM-Nitrophen
  • HY-103427
    NPEC-caged-dopamine

    		Dopamine Receptor Neurological Disease
    NPEC-caged-dopamine is a caged version of dopamine. NPEC-caged-Dopamine was used by applying focal photolysis with UV light (360 nm) to releases dopamine, which leads to D1 receptor activation .
    NPEC-caged-dopamine
  • HY-126789A
    DM-Nitrophen tertasodium

    		Biochemical Assay Reagents Metabolic Disease
    DM-Nitrophen tertasodium is a photolabile caged calcium compound that acts as a calcium releaser. DM-Nitrophen tertasodium binds Ca 2+ with high affinity and Mg 2+ with considerable affinity before photolysis. DM-Nitrophen tertasodium releases Ca 2+ into the cytosol upon ultraviolet light irradiation. DM-Nitrophen tertasodium induces calcium concentration pulses, triggers cytosolic calcium transients, promotes calcium-dependent exocytosis. DM-Nitrophen tertasodium can be used for the research of calcium-dependent cellular processes .
    DM-Nitrophen tertasodium
  • HY-131039
    MDNI-caged-L-glutamate

    MDNI-glu

    		 Amino Acid Derivatives Others
    MDNI-caged-L-glutamate (MDNI-glu) is a biologically inert, photosensitive derivative of the major excitatory amino acid, L-glutamate. MDNI-caged-L-glutamate makes more efficient use of incident light .
    MDNI-caged-L-glutamate
  • HY-N8727
    Isomorellic acid

    		Others Cancer
    Isomorellic acid is a cytotoxic caged xanthone and can be used for cancer research .
    Isomorellic acid
  • HY-D1343
    DMNPE-caged D-luciferin

    		Fluorescent Dye
    DMNPE-caged D-luciferin is a heterocyclic luminescent compound that is a natural ligand for luciferase, an enzyme used to detect cell activity. Its reaction requires ATP and emits yellow-green light with a peak wavelength of about 530 nm. The luciferin in the DMNPE cage easily crosses the cell membrane.
    DMNPE-caged D-luciferin
  • HY-N2427S
    Adamantane-d16

    		Isotope-Labeled Compounds Others
    Adamantane-d16is the deuterium labeled Adamantane (HY-N2427). Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .
    Adamantane-d16
  • HY-124086
    BHQ-O-5HT

    		5-HT Receptor Neurological Disease
    BHQ-O-5HT is a light-activated caged 5-HT protected by a BHQ group. When exposed to light at 365 or 740 nm, BHQ-O-5HT releases 5-HT through 1 or 2 photon excitation, respectively. BHQ-O-5HT can be manipulated in space and time to explore the role of 5-HT in regulating mood, appetite, memory, learning, and other cognitive functions .
    BHQ-O-5HT
  • HY-136283
    DMNPE-4 AM-caged-calcium

    		Calcium Channel Neurological Disease
    DMNPE-4 AM-caged-calcium, photolabile analogues of EGTA, is an extremely effective Ca 2+ selective cage, with a Kd for Ca 2+ of 48 nM and 19 nM at pH 7.2 and pH 7.4, respectively. DMNPE-4 AM-caged-calcium has a lower affinity for Ca 2+ (Kd=~2 nM) after photolysis .
    DMNPE-4 AM-caged-calcium
  • HY-103235
    NPEC-caged-(S)-AMPA

    		iGluR Neurological Disease
    NPEC- caged-(S)-AMPA, a caged neurotransmitter analog, is a NPEC photoprotecting group caged the (S)-AMPA (HY-100815A) to make caged ligands specific for glutamate receptor sub-types. NPEC- caged-(S)-AMPA selectively activates AMPA receptor .
    NPEC-caged-(S)-AMPA
  • HY-115231
    ci-IP3/PM

    		Drug Derivative Others
    ci-IP3/PM is a caged and cell permeable derivative of IP3. ci-IP3/PM can induce Ca 2+ release from internal stores .
    ci-IP3/PM
  • HY-103527
    RuBi-GABA

    		GABA Receptor Neurological Disease
    RuBi-GABA is a new ruthenium-based caged GABA compound. RuBi-GABA photocleaves and releases GABA after being excited with visible wavelengths. RuBi-GABA produces gaba receptor-mediated currents .
    RuBi-GABA
  • HY-153056
    BNN3

    		NO Synthase Others
    BNN3 is a caged nitric oxide (NO) donor. BNN3 is membrane-permeant and incorporated in the lipid membrane .
    BNN3
  • HY-N7502
    2-(Hydroxymethyl)anthraquinone

    		Others Others
    2-(Hydroxymethyl)anthraquinone is used as a photoremovable protecting group (PRPG) to chemically cage sex pheromone (e.g. (Z)-11-hexadecen-1-ol (sex pheromone of Chilo infuscatellussnellen)) .
    2-(Hydroxymethyl)anthraquinone
  • HY-113770
    Lysyl threonine

    Lys-Thr

    		 Drug Intermediate Cancer
    Lysyl threonine (Lys-Thr) is a dipeptide. Lysyl threonine can be used to synthesize the pentapeptide Gly-Thr-Gly-Lys-Thr. Gly-Thr-Gly-Lys-Thr confers cell sensitivity to anticancer agents by inhibiting the binding of CAGE to GSK3β and reducing the expression of CyclinD1 .
    Lysyl threonine
  • HY-165624A
    (S)-LY-41

    		Drug Isomer Drug Derivative 5-HT Receptor Neurological Disease
    (S)-LY-41, R-enantiomer of LY-41 (HY-165624), is 2-Sminotetralin (HY-W022362) derivative and 8-OH-DPAT (HY-112061) analogue. (S)-LY-41 is a potent and selective 5-HT1A receptor agonist. (S)-LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015). (S)-LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (S)-LY-41 can induce the 5-HT behavioral syndrome. (S)-LY-41can be used for the research of neurological disease, such as depression and anxiety .
    (S)-LY-41
  • HY-165624B
    (R)-LY-41

    		Drug Isomer Drug Derivative 5-HT Receptor Neurological Disease
    (R)-LY-41, R-enantiomer of LY-41 (HY-165624), is 2-Sminotetralin (HY-W022362) derivative and 8-OH-DPAT (HY-112061) analogue. (R)-LY-41 is a potent and selective 5-HT1A receptor agonist. (R)-LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015). (R)-LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (R)-LY-41 can induce the 5-HT behavioral syndrome but is weaker than (S)-LY-41 (HY-165624A). (R)-LY-41 can be used for the research of neurological disease, such as depression and anxiety .
    (R)-LY-41
  • HY-RS01825
    CAGE1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CAGE1 Human Pre-designed siRNA Set A contains three designed siRNAs for CAGE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CAGE1 Human Pre-designed siRNA Set A
    CAGE1 Human Pre-designed siRNA Set A
  • HY-N2427R
    Adamantane (Standard)

    		Reference Standards Others Others
    Adamantane (Standard) is the analytical standard of Adamantane. This product is intended for research and analytical applications. Adamantane, a polycyclic cage molecule with high symmetry and remarkable properties. Adamantane can be incorporated into a lipophilic part of the lipid bilayer that constitutes membranes and as an anchor in the lipid bilayer of liposomes. Adamantane can be used in research of surface recognition and drug delivery .
    Adamantane (Standard)
  • HY-RS03658
    DDX53 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    DDX53 Human Pre-designed siRNA Set A contains three designed siRNAs for DDX53 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DDX53 Human Pre-designed siRNA Set A
    DDX53 Human Pre-designed siRNA Set A
  • HY-107520A
    MNI-caged-L-glutamate TFA

    		Drug Derivative Neurological Disease
    MNI-caged-L-glutamate TFA is an inert photolabile glutamate precursor. MNI-caged-L-glutamate TFA does not modulate NMDA and AMPA receptor function in cultured neurones. MNI-caged-L-glutamate TFA can be used for research on neurotransmitters .
    MNI-caged-L-glutamate TFA
  • HY-103298
    MNI-caged kainate

    		Endogenous Metabolite Neurological Disease
    MNI-caged kainate is a photoprotected neuroactive amino acid with the activity to generate large inward currents. MNI-caged kainate can be released at the resting membrane potential of Purkinje cells and generate significant inward currents. The release of MNI-caged kainate results in approximately 40% of the current being generated through AMPA receptor activation. MNI-caged kainate is used to study fast synaptic receptor mechanisms. The photorelease time of MNI-caged kainate is in the sub-microsecond range, making it suitable for investigating the mechanisms of fast synaptic transmission .
    MNI-caged kainate
  • HY-164264
    Caged MK801

    		iGluR Neurological Disease
    Caged MK801 (cMK801) is a selective, non-competitive, irreversible NMDA receptor open-channel blocker. NVOC cages are neuro pharmocologically compatible .
    Caged MK801
  • HY-107717
    MNI-caged-NMDA

    		iGluR Neurological Disease
    MNI-caged-NMDA is a light-sensitive amino acid with rapid release properties suitable for use in the study of fast synaptic receptor mechanisms. MNI-caged-NMDA shows metered release of NMDA receptors, inducing rapid and sustained receptor activation in cerebellar interneurons. MNI-caged-NMDA is able to achieve rapid transient responses and generate large inward currents by local laser photolysis. The use of MNI-caged-NMDA can effectively study neurotransmitter signaling and its inhibitory effects on GABA-A receptors .
    MNI-caged-NMDA
  • HY-159110
    ABA-DMNB

    		Drug Derivative Others
    ABA-DMNB is a photo-caged chemically induced proximity (CIP) inducer. ABA-DMNB is a photo-caged ABA (Abscisic acid (HY-100560)). ABA-DMNB can be uncaged under light irradiation and generate active ABA .
    ABA-DMNB
  • HY-103300
    NPE-caged-proton

    		Endogenous Metabolite Infection
    NPE-caged-proton is a reagent that releases protons under UV light and has the activity of activating the fusion protein GP64 under weak acidic conditions. NPE-caged-proton can promote the binding of enveloped viruses to liposome membranes with acidic phospholipids in an environment of pH 4.0 to 5.5, thereby initiating membrane fusion. The ultraviolet unblocking effect of NPE-caged-proton can lower the environmental pH, thereby triggering the process of viral membrane fusion. When studying the interaction between viruses and cell membranes, NPE-caged-proton provides a valuable tool for revealing the subtle behaviors of viruses in different chemical and biochemical environments .
    NPE-caged-proton
  • HY-110304
    NPEC-caged-LY379268

    		mGluR Neurological Disease
    NPEC-caged-LY379268 is a type II mGluR agonist .
    NPEC-caged-LY379268
  • HY-103467
    NPE-caged-HPTS sodium

    		Fluorescent Dye Others
    NPE-caged-HPTS sodium is a caged fluorophore that fluoresces upon uncaged fluorophore release, releasing the free highly polar fluorophore HPTS (Exc=470/40 nm, Em=525/50 nm). HPTS releases the fluorophore rapidly and uniformly, allowing for measurement of diffusion within tissues, with a diffusion coefficient of μm 2s -1, similar to that of synaptic L-glutamate .
    NPE-caged-HPTS sodium
  • HY-103555
    NPEC-caged-(1S,3R)-ACPD

    		Biochemical Assay Reagents Others
    NPEC-caged-(1S,3R)-ACPD is a specific photosensitive ligand for glutamate receptor subtypes.
    NPEC-caged-(1S,3R)-ACPD
  • HY-103526
    DPNI-GABA

    		GABA Receptor Neurological Disease
    DPNI-GABA is a nitroindoline cage compound that inhibits GABA(A) receptors and reduces GABA-evoked peak responses with an IC50 value of 0.5 mM .
    DPNI-GABA
  • HY-N10256
    Varioxepine A

    		Endogenous Metabolite Infection
    Varioxepine A is a 3H-oxepine-containing alkaloid with a new oxa-cage found in the marine algal-derived endophytic fungus Paecilomyces variotii. Varioxepine A inhibits plant pathogenic fungus Fusarium graminearum .
    Varioxepine A
  • HY-N7502R
    2-(Hydroxymethyl)anthraquinone (Standard)

    		Reference Standards Others Others
    2-(Hydroxymethyl)anthraquinone is used as a photoremovable protecting group (PRPG) to chemically cage sex pheromone (e.g. (Z)-11-hexadecen-1-ol (sex pheromone of Chilo infuscatellussnellen)) .
    2-(Hydroxymethyl)anthraquinone (Standard)
  • HY-161005
    TETS-Methyl benzoate

    		Hapten Metabolic Disease
    TETS-Methyl benzoate(compound 2j) is a haptendirectly conjugated to the carrier protein via carboxylic acid function using the standard activated ester method .
    TETS-Methyl benzoate
  • HY-131019
    JF-NP-26

    		mGluR Neurological Disease
    JF-NP-26, an inactive photocaged derivative of raseglurant, is the first caged mGlu5 receptor negative allosteric modulator. Uncaging of JF-NP-26 is elicited with light pulses in the visible spectrum (405 nm). JF-NP-26 induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals .
    JF-NP-26
  • HY-131885
    RuBi-Glutamate hexafluorophosphate sodium

    		GABA Receptor Neurological Disease
    RuBi-Glutamate hexafluorophosphate sodium is a neuronal activator. RuBi-Glutamate hexafluorophosphate sodium photocleaves to release glutamate upon one- or two-photon excitation, activating glutamate receptors in cortical pyramidal neurons. RuBi-Glutamate hexafluorophosphate sodium reduces peak amplitude of evoked GABAergic inhibitory postsynaptic currents in its caged form. RuBi-Glutamate hexafluorophosphate sodium can be used for the research of Huntington's disease .
    RuBi-Glutamate hexafluorophosphate sodium
  • HY-131001
    DPNB-ABT594

    		nAChR Neurological Disease
    DPNB-ABT594 is a nitrobenzyl-caged ABT594 (HY-14316A) and activates nAChRs containing the α4β2 subunits with good selectivity than the α7 subunit. DPNB-ABT594 can be used to map the distribution of nAChRs on neurons of the medial habenula (MHb) and helps to gain a deeper understanding of the nAChR-mediated Ca 2+ signalling in the MHb .
    DPNB-ABT594
  • HY-108578
    RuBi-4AP

    		Potassium Channel Neurological Disease
    RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged Kv channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation .
    RuBi-4AP
  • HY-155817
    UNC7096

    		Histone Methyltransferase Others
    UNC7096 (compound 53) is a biotinylated affinity reagent. The phenyl ring of UNC7096 replaces the pyrimidine ring in UNC6934 (HY-145103) and introduces biotin at the para position of the phenyl ring, which has a high binding affinity to the NSD2-PWWP1 domain (Kd=46 nM). UNC7096 blocks the interaction between NSD2-PWWP1 and nucleosomal H3K36me2 by occupying the methyl-lysine binding pocket of NSD2-PWWP1. This binding is achieved by covalent binding through the formation of hydrogen bonds and a specific aromatic cage structure. UNC7096 can be used to capture proteins that interact with the NSD2-PWWP1 domain to further analyze the biological significance of these interactions .
    UNC7096
  • HY-P11782
    GTGKT

    		GSK-3 CDK Apoptosis Cancer
    GTGKT is a CAGE inhibitor. GTGKT binds to CAGE and blocks the binding of CAGE to GSK3β. GTGKT alters the localization of CAGE and inhibits the binding of CAGE to the promoter sequence of Cyclin D1. GTGKT enhances the Apoptotic effect of anticancer agents. GTGKT reduces the expression of Cyclin D1. GTGKT decreases the tumorigenic potential of melanoma and hepatocellular carcinoma cells .
    GTGKT
  • HY-182134
    NPOM caged-dT-CE phosphoramidite

    		DNA/RNA Synthesis Phosphoramidites Others
    NPOM caged-dT-CE phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
    NPOM caged-dT-CE phosphoramidite
  • HY-182128
    DEACM caged-dG-CE phosphoramidite

    		DNA/RNA Synthesis Phosphoramidites Others
    DEACM caged-dG-CE phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
    DEACM caged-dG-CE phosphoramidite
  • HY-182461
    Deoxymorellin

    		Bacterial Infection
    Deoxymorellin is a caged xanthone found in resins and fruits of Garcinia hanburyi hook. f.. Deoxymorellin exhibits cytotoxicity. Deoxymorellin can be used for research of Methicillin (HY-121544)-resistant or Methicillin-susceptible Staphylococcus aureus .
    Deoxymorellin

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