117367-86-9
Chemical Structure
DM-Nitrophen
- CAS No.: 117367-86-9
- Formula:C18H23N3O12
- Molecular Weight:473.39
IUPAC Name: 2,2',2'',2'''-((1-(4,5-dimethoxy-2-nitrophenyl)ethane-1,2-diyl)bis(azanetriyl))tetraacetic acid
InChIKey: FKXGYESXGMKAKC-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC(OC)=C(OC)C=C1C(N(CC(O)=O)CC(O)=O)CN(CC(O)=O)CC(O)=O)[O-]
Biological Activity: DM-Nitrophen is a photolabile caged calcium compound that acts as a calcium releaser. DM-Nitrophen binds Ca2+ with high affinity and Mg2+ with considerable affinity before photolysis. DM-Nitrophen releases Ca2+ into the cytosol upon ultraviolet light irradiation. DM-Nitrophen induces calcium concentration pulses, triggers cytosolic calcium transients, promotes calcium-dependent exocytosis. DM-Nitrophen can be used for the research of calcium-dependent cellular processes[1][2][3].
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DM-Nitrophen | 98.40% | DM-Nitrophen is a photolabile caged calcium compound that acts as a calcium releaser. DM-Nitrophen binds Ca2+ with high affinity and Mg2+ with considerable affinity before photolysis. DM-Nitrophen releases Ca2+ into the cytosol upon ultraviolet light irradiation. DM-Nitrophen induces calcium concentration pulses, triggers cytosolic calcium transients, promotes calcium-dependent exocytosis. DM-Nitrophen can be used for the research of calcium-dependent cellular processes. | ||||||||||||||||||||
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References
- [1]. Ellis-Davies GC, et al. Laser photolysis of caged calcium: rates of calcium release by nitrophenyl-EGTA and DM-nitrophen. Biophys J. 1996;70(2):1006-1016. [Content Brief]
- [2]. Parsons TD, et al. Millisecond studies of calcium-dependent exocytosis in pituitary melanotrophs: comparison of the photolabile calcium chelators nitrophenyl-EGTA and DM-nitrophen. Cell Calcium. 1996;19(3):185-192. [Content Brief]
- [3]. Currie KP, et al. Activation of Ca(2+)-dependent Cl- currents in cultured rat sensory neurones by flash photolysis of DM-nitrophen. J Physiol. 1995;482 ( Pt 2)(Pt 2):291-307. [Content Brief]
