2941391-49-5
Chemical Structure
DPI-4452
- CAS. Nr.: 2941391-49-5
- Formula:C92H132N22O29S3
- Molecular Weight:2106.36
InChIKey: IGTWTCVMZRKJAW-OMNWDWICSA-N
SMILES: C[C@@H](O)[C@H](NC([C@@H](N1)CC(C)C)=O)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](C(N[C@@H](CSCC4=CC(CSC[C@H](NC([C@@H](NC(CN5CCN(C(CN(CCN6CC(O)=O)CCN(CCN(CC(O)=O)CC6)CC(O)=O)=O)CC5)=O)CCC(N)=O)=O)C(N[C@@H](CCC(O)=O)C(N(CCC7)[C@H]7C(N[C@@H](CC(O)=O)C(N[C@@H](CC8=CC=CC(NC(CCCS(=O)(N)=O)=O)=C8)C1=O)=O)=O)=O)=O)=CC=C4)C(N)=O)=O)CO)=O)=O
Biological Activity: DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC50 for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models[1]. DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
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DPI-4452 | 99.30% | DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC50 for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models. DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). | ||||||||||||||||||||
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Keywords
