291517-40-3
Chemical Structure
DM-Nitrophen tertasodium
- CAS No.: 291517-40-3
- Formula:C18H19N3Na4O12
- Molecular Weight:561.32
InChIKey: KCTLZBKLHCBAMY-UHFFFAOYSA-J
SMILES: O=C(CN(CC(N(CC(O[Na])=O)CC(O[Na])=O)C1=CC(OC)=C(C=C1[N+]([O-])=O)OC)CC(O[Na])=O)O[Na]
Biological Activity: DM-Nitrophen tertasodium is a photolabile caged calcium compound that acts as a calcium releaser. DM-Nitrophen tertasodium binds Ca2+ with high affinity and Mg2+ with considerable affinity before photolysis. DM-Nitrophen tertasodium releases Ca2+ into the cytosol upon ultraviolet light irradiation. DM-Nitrophen tertasodium induces calcium concentration pulses, triggers cytosolic calcium transients, promotes calcium-dependent exocytosis. DM-Nitrophen tertasodium can be used for the research of calcium-dependent cellular processes[1][2][3].
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DM-Nitrophen tertasodium | 90.0% | DM-Nitrophen tertasodium is a photolabile caged calcium compound that acts as a calcium releaser. DM-Nitrophen tertasodium binds Ca2+ with high affinity and Mg2+ with considerable affinity before photolysis. DM-Nitrophen tertasodium releases Ca2+ into the cytosol upon ultraviolet light irradiation. DM-Nitrophen tertasodium induces calcium concentration pulses, triggers cytosolic calcium transients, promotes calcium-dependent exocytosis. DM-Nitrophen tertasodium can be used for the research of calcium-dependent cellular processes. | ||||||||||||||||||||
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References
- [1]. Ellis-Davies GC, et al. Laser photolysis of caged calcium: rates of calcium release by nitrophenyl-EGTA and DM-nitrophen. Biophys J. 1996 Feb;70(2):1006-16. [Content Brief]
- [2]. Parsons TD, et al. Millisecond studies of calcium-dependent exocytosis in pituitary melanotrophs: comparison of the photolabile calcium chelators nitrophenyl-EGTA and DM-nitrophen. Cell Calcium. 1996;19(3):185-192. [Content Brief]
- [3]. Currie KP, et al. Activation of Ca(2+)-dependent Cl- currents in cultured rat sensory neurones by flash photolysis of DM-nitrophen. J Physiol. 1995;482 ( Pt 2)(Pt 2):291-307. [Content Brief]
