2253744-58-8
Chemical Structure
DMNPE-4 AM-caged-calcium
- No. CAS: 2253744-58-8
- Formula:C34H47N3O22
- Molecular Weight:849.74
IUPAC Name: bis(acetoxymethyl) 3,12-bis(2-(acetoxymethoxy)-2-oxoethyl)-5-(4,5-dimethoxy-2-nitrophenyl)-6,9-dioxa-3,12-diazatetradecanedioate
InChIKey: UUZFENOXYOBVDU-UHFFFAOYSA-N
SMILES: O=C(CN(CCOCCOC(C1=C([N+]([O-])=O)C=C(OC)C(OC)=C1)CN(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)OCOC(C)=O
Biological Activity: DMNPE-4 AM-caged-calcium, photolabile analogues of EGTA, is an extremely effective Ca2+ selective cage, with a Kd for Ca2+ of 48 nM and 19 nM at pH 7.2 and pH 7.4, respectively. DMNPE-4 AM-caged-calcium has a lower affinity for Ca2+ (Kd=~2 nM) after photolysis[1][2].
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DMNPE-4 AM-caged-calcium | DMNPE-4 AM-caged-calcium, photolabile analogues of EGTA, is an extremely effective Ca2+ selective cage, with a Kd for Ca2+ of 48 nM and 19 nM at pH 7.2 and pH 7.4, respectively. DMNPE-4 AM-caged-calcium has a lower affinity for Ca2+ (Kd=~2 nM) after photolysis. | |||||||||||||||||||||
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References
- [1]. Ellis-Davies GCR, et, al. Tuning caged calcium: photolabile analogues of EGTA with improved optical and chelation properties. Cell Calcium. 2006 Jan;39(1):75-83. [Content Brief]
- [2]. DelPrincipe F, et, al. Two-photon and UV-laser flash photolysis of the Ca2+ cage, dimethoxynitrophenyl-EGTA-4. Cell Calcium. 1999 Jan;25(1):85-91. [Content Brief]
