Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
CBP-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "CBP-IN-1" in MCE Product Catalog:
Cat. No.: HY-153948
CAS No.: 1936431-44-5
Research Areas:
CBP-IN-1 is a potent CBP inhibitor with an IC50 of 1.5 nM. CBP-IN-1 also inhibits CBP BRET and BRD4 (1), with IC50 values of 690 nM and 3100 nM, respectively. CBP-IN-1 can be used in oncology and immuno-oncology research [1].
Cat. No.: HY-177927
CAS No.: 2750072-14-9
Research Areas:
CBP-IN-1 acid is a CBP Inhibitor-Linker Conjugate composed of CBP-IN-1 (HY-153948) and a linker. CBP-IN-1 acid can be used to synthesize PROTACs, such as CBPD-268 (HY-161369) [1].
Cat. No.: HY-124722
CAS No.: 1450995-09-1
Target:
Research Areas:
OHM1 is an analog of HIF1α CTAD that inhibits its binding with p300/CBP. OHM1 targets CH1 domain with an affinity of 0.53 μM [1].
Cat. No.: HY-160260
CAS No.: 2638507-71-6
Research Areas:
EP300/CBP-IN-1 (compound 172) is a potent EP300/CBP inhibitor with IC50s of 2.3 nM and 2.1 nM for CBP BRD and EP300 BRD, respectively. EP300/CBP-IN-1 has the inhibitory effect on the proliferation of prostate cancer CWR22RV1 cells [1].
Cat. No.: HY-161959
Research Areas:
EP300/CBP ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). EP300/CBP ligand 1 can be used for synthesis dCE-2 (HY-161958) [1].
Cat. No.: HY-149806
CAS No.: 2445335-77-1
Target:
Research Areas:
BD-IN-1 is a pan bromodomain (BD) inhibitor with KD values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 respectively. BD-IN-1 shows antiproliferative activity [1].
Cat. No.: HY-181758
CAS No.: 3109024-12-3
Research Areas:
PROTAC CBP/p300/BRD4 Degrader-1 is a dual-target PROTAC degrader with DC50 values of 8.8 pM (BRD4), 6.55 nM (CBP), and 1.05 nM (p300). PROTAC CBP/p300/BRD4 Degrader-1 induces CRBN- and proteasome-dependent degradation of BRD4 and CBP/p300, downregulates c-Myc and acetyl-H3K27, induces apoptosis. PROTAC CBP/p300/BRD4 Degrader-1 acts as an antiproliferative and antitumor agent, induces tumor growth inhibition in xenograft models. PROTAC CBP/p300/BRD4 Degrader-1 can be used for the research of prostate cancer and colorectal cancer [1].
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
