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Results for "

CCL-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Antibiotic (1) Antibody-Drug Conjugates (ADCs) (6) Apoptosis (7) Bacterial (1) CCR (24) COX (1) DNA Alkylator/Crosslinker (1) Drug-Linker Conjugates for ADC (1) Enterovirus (1) Epigenetic Reader Domain (1) FLT3 (1) Glucocorticoid Receptor (4) Heme Oxygenase (HO) (1) HIV (1) HSP (1) Interleukin Related (7) Isotope-Labeled Compounds (3) Keap1-Nrf2 (1) Liposome (1) Microtubule/Tubulin (4) Mineralocorticoid Receptor (4) Molecular Glues (1) mRNA (1) NF-κB (1) NO Synthase (1) PPAR (3) Protease Activated Receptor (PAR) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) SHP2 (1) Small Interfering RNA (siRNA) (3) STAT (2) TGF-beta/Smad (3) TNF Receptor (4) Topoisomerase (1) VEGFR (2)
By Research Areas:	Cancer (22) Endocrinology (2) Infection (4) Inflammation/Immunology (29) Metabolic Disease (8) Neurological Disease (4)
Oligonucleotides:	Aptamers (3) Chemokine & Receptors (1) Rat Pre-designed siRNA Sets (1) Cationic Lipids (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0673

Pirfenidone Maximum Cited Publications 80 Publications Verification AMR69	TGF-beta/Smad CCR	Inflammation/Immunology Cancer
Pirfenidone (AMR69) is an antifibrotic agent that attenuates *CCL2* and *CCL12* production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces *TGF-β2* protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[2] .

HY-B0498

Bindarit 25+ Cited Publications AF2838	CCR	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23*. Bindarit also has anti-inflammatory activity .

HY-B1203

Fludrocortisone 9α-Fludrocortisone; 9α-Fluorcortisol	Mineralocorticoid Receptor Glucocorticoid Receptor Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Fludrocortisone (9α-Fludrocortisone) is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces *CCL2, IL-6, IL-8* levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, *ERK1/2, mTOR* phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency ^[2] .

HY-P99188

Carlumab 4 Publications Verification CNTO 888	CCR	Cancer
Carlumab (CNTO 888) is a human anti-CCL2 (chemokine ligand 2) monoclonal antibody. Carlumab binds and neutralises profibrotic activities of human CCL2. Carlumab inhibits tumor growth by reducing macrophage infiltration and decreasing tumor microvascular density. Carlumab can be used for the research of cancer, suah as prostate cancer ^[2].

HY-P99781

Plozalizumab MLN-1202	CCR	Inflammation/Immunology Cancer
Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) ^[2] .

HY-B0673R

Pirfenidone (Standard) AMR69 (Standard)	Reference Standards TGF-beta/Smad CCR	Inflammation/Immunology Cancer
Pirfenidone (Standard) is the analytical standard of Pirfenidone. This product is intended for research and analytical applications. Pirfenidone (AMR69) is an antifibrotic agent that attenuates *CCL2* and *CCL12* production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces *TGF-β2* protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[2] .

HY-P990297

*Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5)* 1 Publications Verification	CCR HIV	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human *CCL2/MCP-1* IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV ^[2] .

HY-B0673S1

Deupirfenidone LYT-100; AMR69-d₃	Isotope-Labeled Compounds	Others
Deupirfenidone-d₃ is the deuterium labeled Pirfenidone (HY-B0673). Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[2] .

HY-148100

Emapticap pegol 1 Publications Verification NOX-E36	CCR	Inflammation/Immunology Cancer
Emapticap pegol (NOX-E36) is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36). mNOX-E36 is a murine-specific analogue of NOX-E36, an anti-MCP-1 L-RNA aptamer that was previously shown to attenuate liver fibrosis in mice ^[2] .

HY-B1076

Medrysone 1 Publications Verification HMS; 6α-Methyl-11β-hydroxyprogesterone	VEGFR CCR STAT	Neurological Disease
Medrysone (HMS; 6α-Methyl-11β-hydroxyprogesterone) is a STAT6 modulator and M2 macrophage polarization inducer. Medrysone enhances IL-4-triggered STAT6 activation, upregulates the expression of M2 markers, and promotes the secretion of VEGF and *CCL2. Medrysone also enhances the pro-migratory activity of M2-like* macrophages toward endothelial cells. By regulating macrophage polarization and related repair pathways, Medrysone significantly promotes corneal wound repair in a rat mechanical injury model. Medrysone can be used for research related to corneal injury .

HY-B0673S

Pirfenidone-d5 AMR69-d₅	TGF-beta/Smad CCR	Inflammation/Immunology Cancer
Pirfenidone-d₅ (AMR69-d₅) is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[2] .

HY-170415

EGR-1-IN-3	Interleukin Related	Inflammation/Immunology
EGR-1 IN-3 (Compound 36) is an early growth response 1 (EGR-1)-DNA binding disruptor. EGR-1-IN-3 inhibits TNFα-induced binding of EGR-1 to DNA and expression of genes associated with inflammation (such as TSLP, IL-31, IL-6 and CCL2). EGR-1-IN-3 can be used in the study of inflammatory diseases .

HY-W013675

2-Methoxyhydroquinone	HSP	Inflammation/Immunology
2-Methoxyhydroquinone is a phenolic compound that reduces TNF-α-induced production of chemokine (C-C motif) ligand 2 (CCL2) with an IC₅₀ value of 64.3 µM. 2-Methoxyhydroquinone is also a precursor in the synthesis of the Hsp90 inhibitor Geldanamycin (HY-15230) ^[2].

HY-160552

244cis	Liposome	Others
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .

HY-148100A

Emapticap pegol sodium 1 Publications Verification NOX-E36 sodium	CCR	Cancer
Emapticap pegol sodium is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) ^[2] .

HY-116247

ST247	PPAR	Metabolic Disease Inflammation/Immunology
ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ .

HY-P99149

Anti-Mouse TNFR2 Antibody (TR75-54.7)	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse TNFR2 Antibody (TR75-54.7) is an anti-mouse *TNFR2* IgG monoclonal antibody. Anti-Mouse TNFR2 Antibody (TR75-54.7) can reduce white blood cell count (WBC) and decrease the expression of some pro-inflammatory cytokines such as CCL2 and CXCL5. Anti-Mouse TNFR2 Antibody (TR75-54.7) can be used for researches on inflammation conditions and cancer such as breast cancer ^[2].

HY-RS16514

Ccl2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccl2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccl2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccl2 Mouse Pre-designed siRNA Set A Ccl2 Mouse Pre-designed siRNA Set A

HY-P991208

Flt-3L-Ig (hum/hum) human Flt3L; hFlt3L	FLT3 Interleukin Related CCR	Inflammation/Immunology
Flt-3L-Ig (hum/hum) (hFlt3L) is a Flt3 ligand. Flt-3L-Ig (hum/hum) enhances the release of inflammatory cytokines from myeloid cells and dendritic cells in BRGSF-CBC mice induced by OKT3. Flt-3L-Ig (hum/hum) increases the release of *IL-2, CCL2* and CXCL10 in an OKT3-dependent manner. Flt-3L-Ig (hum/hum) can be used in studies related to cytokine release syndrome. Flt-3L-Ig (hum/hum) can be used in studies related to psoriasis-like skin inflammation ^[2].

HY-163547

PPAR agonist 5	PPAR	Inflammation/Immunology
PPAR agonist 5 (compound 4b) is a potent PPAR agonist with EC₅₀ values of 3.20, 1.51, 1.92 µM for PPARα, PPARβ/δ, PPARγ, respectively. PPAR agonist 5 shows anti-inflammatory effect .

HY-121896

DSHN	SHP2	Cancer
DSHN is a potent small heterodimer partner (SHP) activator. DSHN inhibits Ccl2 expression and secretion by inhibiting p65 activation of Ccl2 promoter activity. DSHN can be used in research of cancer .

HY-W104821

Rosolic acid	Keap1-Nrf2	Metabolic Disease
Rosolic Acid is an activator of *Nrf2, as well as its downstream targets. Rosolic Acid increases the levels of angiogenic factors, decreases inflammation (TNF-α* and IL-1β) and apoptotic markers (CXCL10 and *CCL2*). Rosolic Acid restores the function of pancreatic cells and protects endothelial cells (ECs) from endoplasmic reticulum stressed .

HY-176255

TBK1 degrader-4	Molecular Glues Interleukin Related CCR	Inflammation/Immunology
TBK1 degrader-4 (Compound 30) is a molecular glue degrader targeting TBK1. TBK1 degrader-4 effectively inhibits cyst growth, alleviates inflammation, and reduces the levels of pro-inflammatory factors such as Ccl2, IFNβ, and IL-6. TBK1 degrader-4 is promising for research of autosomal dominant polycystic kidney disease (ADPKD) .

HY-178926

RAGE406R	CCR TNF Receptor Interleukin Related	Metabolic Disease Inflammation/Immunology Endocrinology
RAGE406R is an orally active RAGE-DIAPH1 interaction antagonist. RAGE406R can bind to ctRAGE and prevent the formation of the RAGE-DIAPH1 complex and inhibit its interaction. RAGE406R can reduce the expression of *CCL2, TNF, and IL-6* in THP1 cells. RAGE406R suppresses delayed-type hypersensitivity in T2D mice. RAGE406R can be used for the study of diabetes .

HY-174763

*Human CCL2* mRNA**	mRNA	Inflammation/Immunology
Human CCL2 mRNA encodes the human C-C motif chemokine ligand 2 (CCL2) protein. CCL2 displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis.

HY-RS02089

CCL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL2 Human Pre-designed siRNA Set A CCL2 Human Pre-designed siRNA Set A

HY-P11553

ECL1i	CCR	Inflammation/Immunology
ECL1i is an allosteric, selective *CCR2* inhibitor. ECL1i specifically inhibits CCL2-/CCR2-mediated chemotaxis. ECL1i interferes with CCR2-positive cell recruitment and attenuates disease progression in experimental autoimmune encephalomyelitis .

HY-P11553A

ECL1i TFA	CCR	Infection Inflammation/Immunology
ECL1i TFA is an allosteric, selective *CCR2* inhibitor. ECL1i TFA specifically inhibits CCL2-/CCR2-mediated chemotaxis. ECL1i TFA interferes with CCR2-positive cell recruitment and attenuates disease progression in experimental autoimmune encephalomyelitis .

HY-165528

Histamine glutarimide XC8	CCR	Inflammation/Immunology
Histamine glutarimide (XC8) is an orally active anti-asthma agent. Histamine glutarimide blocks the maturation of chemokines (CCL2, *CCL7, CCL8, CCL13*) and inhibits the migration of eosinophils and the degranulation of mast cells. In asthma models induced by carrageenan and rat ovalbumin, Histamine glutarimide can reduce airway resistance and the count of eosinophils in bronchoalveolar lavage fluid. Histamine glutarimide can be used in asthma research .

HY-N3887

Evoxine Haplophytin B; Haplophytine B	Bacterial	Infection
Evoxine (Haplophytin B) is a compound that selectively inhibits CO2-induced immunosuppression and has activity in inhibiting the expression of interleukin-6 and chemokine CCL2 in human THP-1 macrophages. Evoxine shows antimicrobial activity against a wide range of bacteria, especially performing well in minimum inhibitory concentration (MIC) tests against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. Evoxine extracts may find application in crude drug preparations in West Africa, provided that their in vivo toxicity results are negative .

HY-171683

*Anti-CCL2* (Carlumab)-VcMMAE**	Antibody-Drug Conjugates (ADCs) CCR Microtubule/Tubulin Apoptosis	Cancer
Anti-CCL2 (Carlumab)-VcMMAE is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated with valine-citrulline (vc) and the tubulin inhibitor MMAE (HY-15162). The ADC toxic molecule and linker part are McMMAE (HY-15575). Anti-CCL2 (Carlumab)-VcMMAE induces apoptosis and can be used in cancer research ^[2].

HY-171682

*Anti-CCL2* (Carlumab)-McMMAF**	Antibody-Drug Conjugates (ADCs) CCR Microtubule/Tubulin Apoptosis	Cancer
Anti-CCL2 (Carlumab)-McMMAF is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated to the protective group maleimidocaproyl and the tubulin inhibitor MMAF (HY-15579). The ADC toxic molecule and linker part are McMMAF (HY-15578). Anti-CCL2 (Carlumab)-McMMAF induces apoptosis and can be used in cancer research ^[2].

HY-171681

*Anti-CCL2* (Carlumab)-SPDB-DM4**	Antibody-Drug Conjugates (ADCs) CCR Microtubule/Tubulin	Cancer
Anti-CCL2 (Carlumab)-SPDB-DM4 is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated with the linker SPDB (HY-12448) and the tubulin inhibitor DM4 (HY-12454). The ADC toxic molecule and linker part are sulfo-SPDB-DM4 (HY-101141). Anti-CCL2 (Carlumab)-SPDB-DM4 can be used in cancer research ^[2].

HY-171680

*Anti-CCL2* (Carlumab)-SMCC-DM1**	Antibody-Drug Conjugates (ADCs) CCR Microtubule/Tubulin	Cancer
Anti-CCL2 (Carlumab)-SMCC-DM1 is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated to the linker SMCC (HY-42360) and the cytotoxic microtubule inhibitor DM1 (HY-19792). The ADC toxic molecule and linker part are SMCC-DM1 (HY-101070). Anti-CCL2 (Carlumab)-SMCC-DM1 can be used in the research of cancer, especially prostate cancer ^[2].

HY-171684

*Anti-CCL2* (Carlumab)-MC-Vc-PAB-SN38**	Antibody-Drug Conjugates (ADCs) CCR Topoisomerase	Cancer
Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38 is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated to the linker Mc-VC-PAB and the topoisomerase I inhibitor SN38 (HY-13704). The ADC toxic molecule and linker part are Mc-VC-PAB-SN38 (HY-131057). Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38 can be used in cancer research ^[2].

HY-171685

*Anti-CCL2* (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA**	Antibody-Drug Conjugates (ADCs) CCR DNA Alkylator/Crosslinker ADC Payload Antibiotic Apoptosis	Cancer
Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated with the linker MC-Vc-PAB-DMEA-PEG2 and the DNA alkylator Duocarmycin SA (HY-12456). Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA can be used in cancer research ^[2].

HY-RS22945

Ccl2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccl2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccl2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccl2 Rat Pre-designed siRNA Set A Ccl2 Rat Pre-designed siRNA Set A

HY-108554

Q94 hydrochloride	Protease Activated Receptor (PAR)	Others
Q94 hydrochloride, a selective PAR₁ antagonist (IC₅₀=916 nM), can selectively block PAR₁/Gαq interaction and signalling. Q94 hydrochloride blocks PAR₁-mediated increases in both *CCL2* mRNA and protein levels in a dose-dependent manner. Q94 hydrochloride also completely blocks thrombin-induced *ERK1/2* and MLC phosphorylation .

HY-168782

Resolvin D2 n-3 DPA	TNF Receptor Interleukin Related	Inflammation/Immunology
Resolvin D2 n-3 DPA is a specialized proresolving mediator (SPM). Resolvin D2 n-3 DPA (1 nM) can reduce the chemotaxis and adhesion of human neutrophils induced by TNF-α. Resolvin D2 n-3 DPA (100 ng/mouse; intravenous injection) can reduce neutrophil infiltration in the peritoneum and the levels of IL-6 and the chemokine (C-C motif) ligand 2 (CCL2) in a mouse model of inflammation induced by zinc oxide .

HY-B1076R

Medrysone (Standard) HMS (Standard); 6α-Methyl-11β-hydroxyprogesterone (Standard)	Reference Standards STAT VEGFR CCR	Inflammation/Immunology
Medrysone (Standard) is the analytical standard of Medrysone. This product is intended for research and analytical applications. Medrysone (HMS; 6α-Methyl-11β-hydroxyprogesterone) is a STAT6 modulator and M2 macrophage polarization inducer. Medrysone enhances IL-4-triggered STAT6 activation, upregulates the expression of M2 markers, and promotes the secretion of VEGF and *CCL2. Medrysone also enhances the pro-migratory activity of M2-like* macrophages toward endothelial cells. By regulating macrophage polarization and related repair pathways, Medrysone significantly promotes corneal wound repair in a rat mechanical injury model. Medrysone can be used for research related to corneal injury ^[2].

HY-171895

12-Nitrolinoleate 12-Nitro-9-cis,12-cis-octadecadienoic acid	PPAR Interleukin Related NF-κB TNF Receptor	Inflammation/Immunology
12-Nitrolinoleate (12-Nitro-9-cis,12-cis-octadecadienoic acid) is an activator for peroxisome proliferator-activated receptor γ (PPARγ). 12-Nitrolinoleate is a nitrated form of linoleic acid. 12-Nitrolinoleate can be formed upon exposure to acidified nitrate and found in human red blood cells and plasma. 12-Nitrolinoleate can activate PPARγ-dependent gene expression in MCF-7 cells expressing PPARγ with an EC₅₀ = 0.045 μM. 12-Nitrolinoleate is able to inhibit LPS (HY-D1056)-induced NF-κB transcription in RAW 264.7 cells. 12-Nitrolinoleate can inhibit IL-6, TNF-α and *CCL2* induced by LPS ^[2] .

HY-173518

SIN 14	Heme Oxygenase (HO) Reactive Oxygen Species (ROS) NO Synthase COX Interleukin Related	Inflammation/Immunology
SIN 14, a derivative of Sinomenine (HY-15122), is an orally active HO-1 activator (K_D = 17.2 μM). SIN 14 binds to the catalytic core domain of HO-1 and induces HO-1 activation in catalysis. SIN 14 significantly increases HO-1 stability. SIN 14 has anti-inflammatory effects and inhibits M1 macrophage polarization while promoting M2 polarization in LPS (Lipopolysaccharides)(HY-D1056)-induced RAW264.7 cells. SIN 14 inhibits inflammatory mediator production (eg: NO, IL-6, IL-1β and CCL2, inhibits production of ROS and down-regulates the expression of *COX-2* and iNOS. SIN 14 can inhibit RA-related inflammatory edema in collagen-induced arthritis (ClA) mice .

HY-B1203S

Fludrocortisone-d5 9α-Fludrocortisone-d₅; 9α-Fluorcortisol-d₅	Isotope-Labeled Compounds Mineralocorticoid Receptor Glucocorticoid Receptor Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Fludrocortisone-d₅ (9α-Fludrocortisone-d₅) is the deuterium labeled Fludrocortisone (HY-B1203). Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces *CCL2, IL-6, IL-8* levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, *ERK1/2, mTOR* phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.

HY-B1203R

Fludrocortisone (Standard) 9α-Fludrocortisone (Standard); 9α-Fluorcortisol (Standard)	Reference Standards Mineralocorticoid Receptor Glucocorticoid Receptor Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Fludrocortisone (Standard) (9α-Fludrocortisone (Standard)) is the analytical standard of Fludrocortisone (HY-B1203). This product is intended for research and analytical applications. Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces *CCL2, IL-6, IL-8* levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, *ERK1/2, mTOR* phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.

HY-B1203S1

Fludrocortisone-d2 9α-Fludrocortisone-d₂; 9α-Fluorcortisol-d₂	Isotope-Labeled Compounds Mineralocorticoid Receptor Glucocorticoid Receptor Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Fludrocortisone-d₂ (9α-Fludrocortisone-d₂) is the deuterium labeled Fludrocortisone (HY-B1203). Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces *CCL2, IL-6, IL-8* levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, *ERK1/2, mTOR* phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.

HY-177933

mNOX-E36	CCR	Neurological Disease Inflammation/Immunology
mNOX-E36 is a murine-specific analogue of NOX-E36 (HY-148100), an anti-CCL-2 L-RNA aptamer that binds and neutralises the mouse chemokine CCL-2. mNOX-E36 reduces scarring in an experimental murine model of glaucoma filtration surgery (GFS). mNOX-E36 ameliorates lupus nephritis in mice. mNOX-E36 can be used for GFS and lupus nephritis research ^[2].

HY-185153

MC-VC-PAB-DMEA-PEG2-Duocarmycin SA	Drug-Linker Conjugates for ADC	Cancer
MC-VC-PAB-DMEA-PEG2-Duocarmycin SA is a drug-linker conjugate for ADC. MC-VC-PAB-DMEA-PEG2-Duocarmycin SA can be coupled with Carlumab (HY-P99188) to form Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA (HY-171685).

HY-180831

BRD4 D1-IN-3	Epigenetic Reader Domain	Metabolic Disease Inflammation/Immunology
BRD4 D1-IN-3 (compound 39) is a potent, selective, and cell-active BRD4-D1 inhibitor (IC₅₀ = 39 nM, K_i = 2.4 nM) with >1700-fold selectivity over *BRD2-D1. BRD4 D1-IN-3 reduces the expression of pro-inflammatory chemokines CXCL1* and *CCL2* in an LPS (HY-D1056)-mediated cellular model of liver inflammation. BRD4 D1-IN-3 can be used for liver inflammation research .

HY-181680

ATPase-IN-8	Enterovirus	Infection
ATPase-IN-8 is an anti-enteroviral agent that inhibits the viral non-structural protein 2C, with an IC₅₀ of 1.4 μM against CV-B3 2C ATPase. ATPase-IN-8 exhibits significant anti-enteroviral activity and acts as a potent, selective inhibitor of CV-B3 and EV-D68. ATPase-IN-8 can be used for research on enteroviral infections .

Cat. No.	Product Name	Target	Research Area

HY-P11553

ECL1i	CCR	Inflammation/Immunology
ECL1i is an allosteric, selective *CCR2* inhibitor. ECL1i specifically inhibits CCL2-/CCR2-mediated chemotaxis. ECL1i interferes with CCR2-positive cell recruitment and attenuates disease progression in experimental autoimmune encephalomyelitis .

HY-P11553A

ECL1i TFA	CCR	Infection Inflammation/Immunology
ECL1i TFA is an allosteric, selective *CCR2* inhibitor. ECL1i TFA specifically inhibits CCL2-/CCR2-mediated chemotaxis. ECL1i TFA interferes with CCR2-positive cell recruitment and attenuates disease progression in experimental autoimmune encephalomyelitis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99188

Carlumab 4 Publications Verification CNTO 888	CCR	Cancer
Carlumab (CNTO 888) is a human anti-CCL2 (chemokine ligand 2) monoclonal antibody. Carlumab binds and neutralises profibrotic activities of human CCL2. Carlumab inhibits tumor growth by reducing macrophage infiltration and decreasing tumor microvascular density. Carlumab can be used for the research of cancer, suah as prostate cancer ^[2].

HY-P99781

Plozalizumab MLN-1202	CCR	Inflammation/Immunology Cancer
Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) ^[2] .

HY-P990297

*Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5)* 1 Publications Verification	CCR HIV	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human *CCL2/MCP-1* IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV ^[2] .

HY-P99149

Anti-Mouse TNFR2 Antibody (TR75-54.7)	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse TNFR2 Antibody (TR75-54.7) is an anti-mouse *TNFR2* IgG monoclonal antibody. Anti-Mouse TNFR2 Antibody (TR75-54.7) can reduce white blood cell count (WBC) and decrease the expression of some pro-inflammatory cytokines such as CCL2 and CXCL5. Anti-Mouse TNFR2 Antibody (TR75-54.7) can be used for researches on inflammation conditions and cancer such as breast cancer ^[2].

HY-P991208

Flt-3L-Ig (hum/hum) human Flt3L; hFlt3L	FLT3 Interleukin Related CCR	Inflammation/Immunology
Flt-3L-Ig (hum/hum) (hFlt3L) is a Flt3 ligand. Flt-3L-Ig (hum/hum) enhances the release of inflammatory cytokines from myeloid cells and dendritic cells in BRGSF-CBC mice induced by OKT3. Flt-3L-Ig (hum/hum) increases the release of *IL-2, CCL2* and CXCL10 in an OKT3-dependent manner. Flt-3L-Ig (hum/hum) can be used in studies related to cytokine release syndrome. Flt-3L-Ig (hum/hum) can be used in studies related to psoriasis-like skin inflammation ^[2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0498

Bindarit 25+ Cited Publications AF2838	Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Umbelliferae Plants Disease Research Fields Echinacea angustifolia DC. Endocrinology Source Classification Cancer	CCR
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23*. Bindarit also has anti-inflammatory activity .

HY-N3887

Evoxine Haplophytin B; Haplophytine B	Alkaloids Other Alkaloids Rutaceae Plants Haplophyllum acutifolium (DC.) G. Don Source Classification	Bacterial
Evoxine (Haplophytin B) is a compound that selectively inhibits CO2-induced immunosuppression and has activity in inhibiting the expression of interleukin-6 and chemokine CCL2 in human THP-1 macrophages. Evoxine shows antimicrobial activity against a wide range of bacteria, especially performing well in minimum inhibitory concentration (MIC) tests against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. Evoxine extracts may find application in crude drug preparations in West Africa, provided that their in vivo toxicity results are negative .

Species:	Human (5) Rat (1) Mouse (6) Cynomolgus (1) Pig (1)
Tag:	His (10) Tag Free (3) Avi (2) Fc (1)
Source:	HEK293 (7) Sf9 insect cells (2) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700231AF

	*Animal-Free MCP-1/CCL2* Protein, Pig (His)** C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Pig	E. coli
	MCP-1/CCL2 protein acts as a ligand for CCR2, inducing chemotactic responses and calcium mobilization. It attracts monocytes and basophils but not neutrophils or eosinophils. Animal-Free MCP-1/CCL2 Protein, Pig (His) is the recombinant pig-derived animal-Free MCP-1/CCL2 protein, expressed by E. coli , with N-His labeled tag.This product is for cell culture use only.

HY-P704401

	*MCP-1/CCL2* Protein, Human (HEK293, hFc)** C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 (human) acts as a ligand for CCR2, triggering a potent chemotactic response and intracellular calcium mobilization upon CCR2 binding. It specifically attracts monocytes and basophils while sparing neutrophils and eosinophils. MCP-1/CCL2 Protein, Human (HEK293, hFc) is the recombinant human-derived MCP-1/CCL2 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P7764

	*MCP-1/CCL2* Protein, Mouse** Maximum Cited Publications 9 Publications Verification rMuCCL2; C-C motif chemokine 2; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1; CCL2; Scya2	Mouse	E. coli
	MCP-1/CCL2 Protein, Mouse is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse is a mouse MCP-1/CCL2 (Q24-R96) expressed by E.coil.

HY-P700034AF

	*Animal-Free MCP-1/CCL2* Protein, Human (His)** 3 Publications Verification C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	E. coli
	MCP-1/CCL2 (human) acts as a ligand for CCR2, triggering a potent chemotactic response and intracellular calcium mobilization upon CCR2 binding. It specifically attracts monocytes and basophils while sparing neutrophils and eosinophils. Animal-Free MCP-1/CCL2 Protein, Human (His) is the recombinant human-derived animal-FreeMCP-1/CCL2 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P700787

	*MCP-1/CCL2* Protein, Cynomolgus (HEK293, His)** C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Cynomolgus	HEK293
	MCP-1/CCL2 protein activates CCR2 and induces chemotaxis and calcium ion mobilization. It attracts monocytes and basophils, not neutrophils or eosinophils. It also contributes to neuropathic pain and enhances synaptic transmission in dopamine neurons. MCP-1/CCL2 exists as a monomer or homodimer and binds to endothelial cells through proteoglycans. It interacts with TNFAIP6 via its Link domain. MCP-1/CCL2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived MCP-1/CCL2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P78488

	*MCP-1/CCL2* Protein, Human (HEK293, His-Avi)** C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 Protein, Human (HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (HEK293, His-Avi) is a recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.

HY-P78173

	*MCP-1/CCL2* Protein, Human (Biotinylated, HEK293, His-Avi)** C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.

HY-P7235

	*MCP-1/CCL2* Protein, Mouse (HEK293)** rMuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	HEK293
	MCP-1/CCL2 Protein, Mouse (HEK293) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (HEK293) is a mouse MCP-1/CCL2 (Q24-R96) expressed by HEK293.

HY-P7237

	*MCP-1/CCL2* Protein, Human** Maximum Cited Publications 9 Publications Verification rHuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Human	E. coli
	MCP-1/CCL2 Protein, Human is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human is a recombinant human MCP-1/CCL2(Q24-T99) expressed by E.coil.

HY-P7236

	*MCP-1/CCL2* Protein, Rat (HEK293, C-His)** 1 Publications Verification rRtMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Rat	HEK293
	MCP-1/CCL2 Protein, Rat (HEK293, His) is a small cytokine that belongs to the CC chemokine family.

HY-P700164AF

	*Animal-Free MCP-1/CCL2* Protein, Mouse (His)** Monocyte Chemotactic Protein-1; MCP-1; JE	Mouse	E. coli
	The MCP-1/CCL2 protein, as a CCR2 ligand, induces potent chemotactic responses and intracellular calcium mobilization in monocytes and basophils, without affecting neutrophils or eosinophils.It is critical for neuropathic pain and enhances NMDA-mediated synaptic transmission in neurons containing dopamine D1 and D2 receptors, possibly involving MAPK/ERK-dependent GRIN2B/NMDAR2B phosphorylation.Animal-Free MCP-1/CCL2 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeMCP-1/CCL2 protein, expressed by E.coli , with N-His labeled tag.This product is for cell culture use only.

HY-P72757

	*MCP-1/CCL2* Protein, Mouse (HEK293, His)** C-C motif chemokine ligand 2; GDCF-2; HC11; HSMCR30; MCAF; SCYA2; SMC-CF	Mouse	HEK293
	MCP-1/CCL2 Protein, Mouse (HEK293, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (HEK293, His) is a mouse MCP-1/CCL2 expressed by HEK293 with a His tag at the C-terminus.

HY-P74758

	*MCP-1/CCL2* Protein, Mouse (sf9, His)** C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	Sf9 insect cells
	MCP-1/CCL2 Protein, Mouse (sf9, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (sf9, His) is a mouse MCP-1/CCL2 expressed by Spodoptera frugiferda(Sf9) with a His tag at the C-terminus.

HY-P76489

	*MCP-1/CCL2* Protein, Mouse (Biotinylated, sf9, His)** C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	Sf9 insect cells
	MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) is a biotinylated mouse MCP-1/CCL2 (M1-N148) expressed by Spodoptera frugiferda(Sf9) with a His tag at the C-terminus.

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HY-B0673S1

Deupirfenidone
Deupirfenidone-d₃ is the deuterium labeled Pirfenidone (HY-B0673). Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[2] .

HY-B0673S

Pirfenidone-d5
Pirfenidone-d₅ (AMR69-d₅) is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities ^[2] .

HY-B1203S

Fludrocortisone-d5

Fludrocortisone-d₅ (9α-Fludrocortisone-d₅) is the deuterium labeled Fludrocortisone (HY-B1203). Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.

HY-B1203S1

Fludrocortisone-d2

Fludrocortisone-d₂ (9α-Fludrocortisone-d₂) is the deuterium labeled Fludrocortisone (HY-B1203). Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81171

	MCP1 Antibody MCP-1/CCL2; C-C motif chemokine 2; CCL 2; CCL2; CCL2_HUMAN; Chemokine (C C motif) ligand 2; Chemokine C C motif ligand 2; Chemokine CC Motif Ligand 2; GDCF 2; GDCF 2 HC11; GDCF-2; GDCF2; HC11; HSMCR30; HSMCR30; JE; MCAF; MCP 1; MCP-1; MGC9434; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte secretory protein JE; SCYA2; Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je); Small inducible cytokine A2; Small inducible cytokine subfamily A (Cys Cys), member 2; Small inducible cytokine subfamily A Cys Cys member 2; Small-inducible cytokine A2; SMC CF; SMC-CF; SMCCF.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Rat
	MCP1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MCP1.

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HY-148100

Emapticap pegol 1 Publications Verification NOX-E36		Aptamers
Emapticap pegol (NOX-E36) is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36). mNOX-E36 is a murine-specific analogue of NOX-E36, an anti-MCP-1 L-RNA aptamer that was previously shown to attenuate liver fibrosis in mice ^[2] .

HY-160552

244cis		Cationic Lipids
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .

HY-148100A

Emapticap pegol sodium 1 Publications Verification NOX-E36 sodium		Aptamers
Emapticap pegol sodium is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) ^[2] .

HY-RS16514

Ccl2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ccl2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccl2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174763

*Human CCL2* mRNA**		mRNA Chemokine & Receptors
Human CCL2 mRNA encodes the human C-C motif chemokine ligand 2 (CCL2) protein. CCL2 displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis.

HY-RS02089

CCL2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS22945

Ccl2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ccl2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccl2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-177933

mNOX-E36		Aptamers
mNOX-E36 is a murine-specific analogue of NOX-E36 (HY-148100), an anti-CCL-2 L-RNA aptamer that binds and neutralises the mouse chemokine CCL-2. mNOX-E36 reduces scarring in an experimental murine model of glaucoma filtration surgery (GFS). mNOX-E36 ameliorates lupus nephritis in mice. mNOX-E36 can be used for GFS and lupus nephritis research ^[2].

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