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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
CDK9-IN-11
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "CDK9-IN-11" in MCE Product Catalog:
Research Areas:
CDK9-IN-11 is a potent CDK9 inhibitor. CDK9-IN-11 is the ligand for the PROTAC CDK9 Degrader-1 (HY-103628) .
Cat. No.: HY-170978
CAS No.: 3039540-19-4
PROTAC CDK9 degrader-11 is an orally active, selective CDK9 PROTAC degrader with a DC50 of 1.09 nM. PROTAC CDK9 degrader-11 recruits CRBN to form a ternary complex and degrades CDK9 via the ubiquitin-proteasome pathway, thereby inhibiting RNA polymerase II phosphorylation and downregulating the expression of anti-apoptotic and pro-oncogenic genes, ultimately inducing apoptosis. PROTAC CDK9 degrader-11 is suitable for research on small-cell lung cancer (SCLC) .
Cat. No.: HY-W247437
CAS No.: 1472731-41-1
Target:
Research Areas:
E3 ligase Ligand 56 is the ligand for E3 ligase Cereblon and can be used for syntheisis of PROTAC CDK9 degrader-11 (HY-170978) .
Cat. No.: HY-170979
CAS No.: 3039540-24-1
Research Areas:
CDK9 ligand 3 is the ligand for CDK9 and can be used for synthesis of PROTAC degrader PROTAC CDK9 degrader-11 (HY-170978) .
Cat. No.: HY-170980
CAS No.: 2930001-60-6
Research Areas:
E3 Ligase Ligand-linker Conjugate 166 is the conjugate composed of a E3 ligase ligand and a linker. E3 Ligase Ligand-linker Conjugate 166 can be used for synthesis of PROTAC CDK9 degrader-11 (HY-170978) .
Cat. No.: HY-182764
CDK11-IN-1 is an orally active cyclin-dependent kinase 11 (CDK11) inhibitor with an IC50 of 4 nM, and it exhibits high selectivity against other kinases including CDK7 and CDK9. CDK11-IN-1 inhibits tumor growth in lung cancer xenograft models. CDK11-IN-1 can be used for lung cancer research .
Cat. No.: HY-182764A
CDK11-IN-1 hydrochloride is an orally active cyclin-dependent kinase 11 (CDK11) inhibitor with an IC50 of 4 nM, and it exhibits high selectivity against other kinases including CDK7 and CDK9. CDK11-IN-1 hydrochloride inhibits tumor growth in lung cancer xenograft models. CDK11-IN-1 hydrochloride can be used for lung cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
