CDK11-IN-1
CDK11-IN-1 is an orally active cyclin-dependent kinase 11 (CDK11) inhibitor with an IC50 of 4 nM, and it exhibits high selectivity against other kinases including CDK7 and CDK9. CDK11-IN-1 inhibits tumor growth in lung cancer xenograft models. CDK11-IN-1 can be used for lung cancer research.
For research use only. We do not sell to patients.
- Formula: C19H20FN5
- Molecular Weight:337.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK11 4 nM (IC50) |
CDK11-IN-1 (Compound 37) (72 h) inhibits the growth of KHOS osteosarcoma cells and LU99 lung cancer cells in CellTiter-Glo assays, with a GI50 of 3.7 μM against the former and 0.40 μM against the latter[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | Tmax | T1/2 | AUClast |
|---|---|---|---|---|---|---|
| Mice[1] | 15 mg/kg | p.o. | 489 ng/mL | 0.5 h | 1.09 h | 833 ng·h/mL |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice (NU/JInv) (female, 7-8 weeks old)[1]
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Dosage:10 mg/kg; 30 mg/kg; 100 mg/kg (once daily); 100 mg/kg (twice daily)
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Administration:p.o.; once daily; 14 days; p.o.; twice daily; 14 days
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Result:Showed no significant body weight loss or clinical signs across all dosing regimens.
Did not significantly inhibit tumour growth with once-daily dosing at 10, 30, and 100 mg/kg.
Achieved 30% tumour growth inhibition (TGI) on Day 14 with twice-daily dosing at 100 mg/kg.
Chemical Information
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Molecular Weight 337.39
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Formula C19H20FN5
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SMILES
F[C@H](CNC1)C[C@@H]1NC2=NC(C(C=C3)=CN3C4=CC=CC=C4)=CC=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK11-IN-1 Related Classifications
HY-182764 Related Classifications
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