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Results for "

Ca 2 sensitive

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (9) Na+/Ca2+ Exchanger (1) Adenylate Cyclase (2) Antibiotic (1) Apoptosis (3) Autophagy (2) Bacterial (1) Bcr-Abl (1) Caspase (1) Drug Metabolite (2) Endogenous Metabolite (1) Environmental Pollutants (1) Ferroptosis (1) Fluorescent Dye (7) GABA Receptor (4) Glutathione Peroxidase (1) GSK-3 (1) HDAC (2) Isotope-Labeled Compounds (2) Mitophagy (2) NF-κB (1) Phosphodiesterase (PDE) (2) Potassium Channel (9) Reference Standards (5) Sodium Channel (3) STAT (1) YAP (1) β-catenin (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (7) Endocrinology (1) Infection (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (15)

By Targets:

Calcium Channel (9)

Na+/Ca2+ Exchanger (1)

Adenylate Cyclase (2)

Antibiotic (1)

Apoptosis (3)

Autophagy (2)

Bacterial (1)

Bcr-Abl (1)

Caspase (1)

Drug Metabolite (2)

Endogenous Metabolite (1)

Environmental Pollutants (1)

Ferroptosis (1)

Fluorescent Dye (7)

GABA Receptor (4)

Glutathione Peroxidase (1)

GSK-3 (1)

HDAC (2)

Isotope-Labeled Compounds (2)

Mitophagy (2)

NF-κB (1)

Phosphodiesterase (PDE) (2)

Potassium Channel (9)

Reference Standards (5)

Sodium Channel (3)

STAT (1)

YAP (1)

β-catenin (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (7)

Endocrinology (1)

Infection (1)

Inflammation/Immunology (2)

Metabolic Disease (1)

Neurological Disease (15)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

GMP Molecules

Targets Recommended: Calcium Channel CRAC Channel Na+/Ca2+ Exchanger Hormone-Sensitive Lipase (HSL) CaSR Calmodulin CaMK VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0246

Carbamazepine Maximum Cited Publications 17 Publications Verification CBZ; NSC 169864	Sodium Channel Autophagy Mitophagy Potassium Channel Calcium Channel HDAC	Neurological Disease Cancer
Carbamazepine is an orally active *pressure-sensitive* sodium ion channel blocker with an IC₅₀** of 131 μM. Carbamazepine blocks voltage gated Na ⁺, Ca ²⁺, and K ⁺ channels, and is also a HDAC inhibitor (IC₅₀: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain .

HY-D1024

Coelenterazine h 3 Publications Verification 2-Deoxycoelenterazine; CLZN-h	Calcium Channel	Neurological Disease
Coelenterazine h (2-Deoxycoelenterazine), a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h is more sensitive to Ca ²⁺, thus providing a valuable tool for measuring small changes in Ca ²⁺ concentrations (Ex/Em = 437/466 nm) .

HY-103474

Bicuculline methiodide 4 Publications Verification (-)-Bicuculline methiodide	GABA Receptor	Neurological Disease
Bicuculline methiodide ((-)-Bicuculline methiodide) is a potent GABA_A blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca ²⁺ -activated K ⁺ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca ²⁺ -activated K ⁺ current .

HY-Y0669

Pipecolic acid 2 Publications Verification	Endogenous Metabolite YAP Glutathione Peroxidase Ferroptosis	Neurological Disease Metabolic Disease Inflammation/Immunology
Pipecolic acid is an orally bioavailable, blood-brain barrier-permeable metabolite of lysine with antioxidant, inhibitor, and inducer activity. Pipecolic acid modulates the YAP-GPX4 signaling pathway, reduces retinal vascular tube formation, and mitigates ferroptosis. Pipecolic acid potentiates voltage-sensitive Ca ²⁺ channel currents and induces neuronal apoptosis. Pipecolic acid can be used for the research of diabetic retinopathy .

HY-B0473

Tetracaine hydrochloride AmethoCaine hydrochloride	Environmental Pollutants Calcium Channel	Neurological Disease
Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca ²⁺ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic .

HY-D1631

Calcium Green-5N AM	Fluorescent Dye Calcium Channel	Neurological Disease
Calcium Green-5N AM is a *Ca ²⁺*-sensitive fluorescent probe (K_d = 14 μM). Calcium Green-5N AM shows enhanced fluorescence intensity upon binding to Ca ²⁺, and it can monitor free Ca ²⁺ in neurons .

HY-101360

1-EBIO 1-Ethyl-2-benzimidazolinone	Potassium Channel	Neurological Disease
1-EBIO is an activator of Ca ²⁺ sensitive K ⁺ channels. 1-EBIO is used to study the role of K ⁺ channels in diverse physiological functions .

HY-D0077

2',7'-Difluorofluorescein Oregon green 488	Fluorescent Dye	Others
2',7'-Difluorofluorescein (Oregon green 488) is a fluorescein derivative and a pH-sensitive fluorescent probe (pK_a ~4.7). Upon excitation at 488 nm, 2',7'-Difluorofluorescein exhibits pH-sensitive fluorescence intensity through the formation of dianions, while its pH sensitivity decreases under excitation at 450 nm, allowing its use in ratiometric pH analysis. 2',7'-Difluorofluorescein can be used for the quantitative analysis of pH values in the range of 2-7 in submicron aerosol particles. 2',7'-Difluorofluorescein undergoes buffer-mediated and buffer-free excited-state proton transfer between different protonated forms, and its cationic form undergoes rapid excited-state deprotonation. 2',7'-Difluorofluorescein is resistant to photodegradation, maintains stable absorption and fluorescence properties within the physiological pH range, and serves as a fluorescent protein label, a component of Ca ²⁺ indicators, a fluorescent imaging agent, and an anisotropy probe .

HY-B0246R

Carbamazepine (Standard) CBZ (Standard); NSC 169864 (Standard)	Reference Standards Sodium Channel Autophagy Mitophagy Potassium Channel Calcium Channel HDAC	Neurological Disease Cancer
Carbamazepine (Standard) is the analytical standard of Carbamazepine. This product is intended for research and analytical applications. Carbamazepine is an orally active *pressure-sensitive* sodium ion channel blocker with an IC₅₀** of 131 μM. Carbamazepine blocks voltage gated Na ⁺, Ca ²⁺, and K ⁺ channels, and is also a HDAC inhibitor (IC₅₀: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain .

HY-104056

Fura Red	Fluorescent Dye	Others
Fura Red is a Ca ²⁺-sensitive fluorescent dye, which decreases in fluorescence with rising [Ca ²⁺] .

HY-100783

(-)-Bicuculline methobromide 4 Publications Verification	GABA Receptor	Neurological Disease
(-)-Bicuculline methobromide is a potent GABA_A blocker. (-)-Bicuculline methobromide alters membrane properties and firing pattern. (-)-Bicuculline methobromide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca ²⁺ -activated K ⁺ channels. (-)-Bicuculline methobromide facilitates burst firing via blocking apamin-sensitive Ca ²⁺ -activated K ⁺ current .

HY-135746

OR-1896 2 Publications Verification	Potassium Channel Phosphodiesterase (PDE) Drug Metabolite Apoptosis	Cardiovascular Disease
OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 is a highly selective phosphodiesterase (PDE) III isoform inhibitor and a powerful vasodilator. OR-1896 can open *ATP-sensitive* K ⁺ channels** and has Ca ²⁺-sensitizing effect. OR-1896 mitigates cardiomyocyte apoptosis, cardiac remodeling and myocardial inflammation .

HY-D1024A

Coelenterazine h hydrochloride 3 Publications Verification 2-Deoxycoelenterazine hydrochloride; CLZN-h hydrochloride	Calcium Channel	Neurological Disease
Coelenterazine h (2-Deoxycoelenterazine) hydrochloride, a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h hydrochloride is more sensitive to Ca ²⁺, thus providing a valuable tool for measuring small changes in Ca ²⁺ concentrations (Ex/Em = 437/466 nm) .

HY-D1631A

Calcium green-5N hexapotassium	Fluorescent Dye	Neurological Disease
Calcium green-5N hexapotassium is a cell-impermeant *Ca ²⁺*-sensitive fluorescent probe. Calcium green-5N hexapotassium shows enhancement in fluorescence intensity on binding Ca ²⁺, and can monitor free Ca ²⁺ in neurons .

HY-B0246S4

Carbamazepine-d4 CBZ-d₄; NSC 169864-d₄	Isotope-Labeled Compounds	Others
Carbamazepine-d₄ (CBZ-d₄) is the deuterium labeled Carbamazepine (HY-B0246) . Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC₅₀ of 131 μM. Carbamazepine blocks voltage gated Na ⁺, Ca ²⁺, and K ⁺ channels, and is also a HDAC inhibitor (IC₅₀: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain.

HY-D2952

BOCA-1-BG	Fluorescent Dye	Others
BOCA-1-BG is a BODIPY-labeled SNAP tag fluorescence probe. BOCA-1-BG can be used to detect Ca ²⁺ concentration and serves as a highly sensitive Ca ²⁺ fluorescent indicator .

HY-100783A

(+)-Bicuculline methochloride	GABA Receptor	Neurological Disease
(+)-Bicuculline methobromide is a potent GABA_A blocker. (+)-Bicuculline methobromide alters membrane properties and firing pattern. (+)-Bicuculline methobromide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca ²⁺ -activated K ⁺ channels. (+)-Bicuculline methobromide facilitates burst firing via blocking apamin-sensitive Ca ²⁺ -activated K ⁺ current .

HY-116540A

L 858051 dihydrochloride 7DMB-Forskolin	Adenylate Cyclase	Cardiovascular Disease
L 858051 (7DMB-Forskolin) dihydrochloride, an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 dihydrochloride directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 dihydrochloride activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg ²⁺-sensitive current in adult rat ventricular myocytes. L 858051 dihydrochloride maximally stimulates L-type Ca ²⁺ current in adult rat ventricular myocytes. L 858051 dihydrochloride increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 dihydrochloride serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes .

HY-B0473R

Tetracaine hydrochloride (Standard) AmethoCaine hydrochloride (Standard)	Reference Standards Calcium Channel	Neurological Disease
Tetracaine (hydrochloride) (Standard) is the analytical standard of Tetracaine (hydrochloride). This product is intended for research and analytical applications. Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic .

HY-N6777R

Penicillic acid (Standard)	Reference Standards Caspase Bacterial Apoptosis Antibiotic	Infection Cancer
Tetracaine (hydrochloride) (Standard) is the analytical standard of Tetracaine (hydrochloride). This product is intended for research and analytical applications. Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic .

HY-D1501

Fura PE-3 potassium	Fluorescent Dye	Others
Fura PE-3 potassium is a Ca ²⁺sensitive fluorophore. Fura PE-3 potassium loads in IPA (intrapulmonary arteries) and MA (mesenteric resistance arteries) for the research of vasoconstriction .

HY-164684

Dichlorobenzamil 3',4'-Dichlorobenzamil; L-594881	Calcium Channel Sodium Channel Na+/Ca2+ Exchanger	Others
Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) is an effective *Na/Ca* exchange inhibitor. Dichlorobenzamil significantly inhibits ⁴⁵Ca uptake mediated by reverse *Na/Ca* exchange in pancreatic islet cells (IC₅₀ = 18 μM). Dichlorobenzamil can also block K ⁺ channels and voltage-sensitive *Ca ²⁺* channels .

HY-147383

NS-8	Potassium Channel	Endocrinology
NS-8, a pyrrole derivative, activates the Ca ²⁺-sensitive k ⁺-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence .

HY-171469

SKP-451	Potassium Channel	Cardiovascular Disease
SKP-451 is an ATP-sensitive potassium (K ⁺) channel agonist. SKP-451 activates the ATP-sensitive K ⁺ channels, promotes the efflux of K ⁺, causes membrane hyperpolarization, and inhibits the influx of Ca ²⁺, thereby relaxing the vascular smooth muscle. SKP-451 relaxs the canine coronary artery, rabbit basilar artery, and vertebral artery. SKP-451 also reduces the mean arterial blood pressure of conscious spontaneously hypertensive rats (SHR). SKP-451 is promising for research of cardiovascular diseases .

HY-D1755

Fluo-3FF AM	Fluorescent Dye	Others
Fluo-3FF AM is a low affinity (Kd = 42 μM) fluorescent Ca ²⁺ sensitive indicator (Abs/Em = 462 nm/526 nm). Fluo-3FF AM is Mg ²⁺ insensitive and relatively photostable. Fluo-3FF AM is an analog of Fluo-3FF AM. Fluo-3FF AM is essentially non-fluorescent, but exhibits a strong fluorescence enhancement upon entry into cells and binding to calcium.

HY-116540

L 858051 7DMB-Forskolin free base	Adenylate Cyclase	Cardiovascular Disease
L 858051 (7DMB-Forskolin free base), an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg ²⁺-sensitive current in adult rat ventricular myocytes. L 858051 maximally stimulates L-type Ca ²⁺ current in adult rat ventricular myocytes. L 858051 increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes .

HY-103474R

Bicuculline methiodide (Standard) (-)-Bicuculline methiodide (Standard)	Reference Standards GABA Receptor	Neurological Disease
Bicuculline methiodide (Standard) is the analytical standard of Bicuculline methiodide (HY-103474). This product is intended for research and analytical applications. Bicuculline methiodide ((-)-Bicuculline methiodide) is a potent GABAA blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current .

HY-135746S

OR-1896-d3	Isotope-Labeled Compounds Phosphodiesterase (PDE) Apoptosis Potassium Channel Drug Metabolite	Cardiovascular Disease
OR-1896-d₃ is the deuterium labeled OR-1896 (HY-135746). OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 is a highly selective phosphodiesterase (PDE) III isoform inhibitor and a powerful vasodilator. OR-1896 can open ATP-sensitive K+ channels and has Ca2+-sensitizing effect. OR-1896 mitigates cardiomyocyte apoptosis, cardiac remodeling and myocardial inflammation .

HY-183206

UR 8225	Potassium Channel Calcium Channel	Cardiovascular Disease Inflammation/Immunology
UR 8225 is an orally active ATP-sensitive K ⁺ channel activator with vasodilator, smooth muscle relaxant, antihypertensive, and bronchodilator activities. UR 8225 induces membrane hyperpolarization by increasing outward K ⁺ conductance and reduces Ca ²⁺ influx through voltage-gated L-type Ca ²⁺ channels. UR 8225 reduces total peripheral vascular resistance, shortens cardiac action potential duration, inhibits agonist-induced Ca ²⁺ influx, and stimulates renin release. UR 8225 induces reflex tachycardia but lacks β-adrenergic receptor blocking activity. UR 8225 is widely applicable to research in fields related to hypertension, myocardial ischemia, ventricular fibrillation, and other conditions .

HY-101360R

1-EBIO (Standard) 1-Ethyl-2-benzimidazolinone (Standard)	Potassium Channel Reference Standards	Cardiovascular Disease Neurological Disease Cancer
1-EBIO (1-Ethyl-2-benzimidazolinone) (Standard) is the analytical standard of 1-EBIO (HY-101360). This product is intended for research and analytical applications. 1-EBIO is an activator of Ca ²⁺ sensitive K ⁺ channels wirh an EC₅₀ of 136 μM for K_Ca3.1. 1-EBIO induces Cl ^- secretion, K ⁺ conductance, membrane hyperpolarization, and afterhyperpolarisation currents. 1-EBIO reduces epileptiform activity, seizure incidence, and rescues cells from Ionomycin (HY-13434)-induced death .

HY-12292G

IM-12	NF-κB STAT GSK-3 β-catenin Bcr-Abl	Cancer
IM-12 GMP is IM-12 (HY-12292) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the NF-κB and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of β-catenin by inhibiting GSK3β, while also blocking the tyrosine kinase activity of p210BCR/ABL. IM-12 reduces the levels of IL-6, IL-17, NO, prostaglandin E2, iNOS and COX-2, and induces ER stress, Ca ²⁺ release, autophagy and apoptosis. IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABL ^T315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan (HY-125474)-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia .

Cat. No.	Product Name	Type

HY-D1631

Calcium Green-5N AM	Fluorescent Dyes
Calcium Green-5N AM is a *Ca ²⁺*-sensitive fluorescent probe (K_d = 14 μM). Calcium Green-5N AM shows enhanced fluorescence intensity upon binding to Ca ²⁺, and it can monitor free Ca ²⁺ in neurons .

HY-104056

Fura Red	Fluorescent Dyes
Fura Red is a Ca ²⁺-sensitive fluorescent dye, which decreases in fluorescence with rising [Ca ²⁺] .

HY-D1631A

Calcium green-5N hexapotassium	Fluorescent Dyes
Calcium green-5N hexapotassium is a cell-impermeant *Ca ²⁺*-sensitive fluorescent probe. Calcium green-5N hexapotassium shows enhancement in fluorescence intensity on binding Ca ²⁺, and can monitor free Ca ²⁺ in neurons .

HY-D2952

BOCA-1-BG	Fluorescent Dyes
BOCA-1-BG is a BODIPY-labeled SNAP tag fluorescence probe. BOCA-1-BG can be used to detect Ca ²⁺ concentration and serves as a highly sensitive Ca ²⁺ fluorescent indicator .

HY-D1755

Fluo-3FF AM	Fluorescent Dyes
Fluo-3FF AM is a low affinity (Kd = 42 μM) fluorescent Ca ²⁺ sensitive indicator (Abs/Em = 462 nm/526 nm). Fluo-3FF AM is Mg ²⁺ insensitive and relatively photostable. Fluo-3FF AM is an analog of Fluo-3FF AM. Fluo-3FF AM is essentially non-fluorescent, but exhibits a strong fluorescence enhancement upon entry into cells and binding to calcium.

HY-12292G

IM-12	Fluorescent Dyes
IM-12 GMP is IM-12 (HY-12292) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the NF-κB and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of β-catenin by inhibiting GSK3β, while also blocking the tyrosine kinase activity of p210BCR/ABL. IM-12 reduces the levels of IL-6, IL-17, NO, prostaglandin E2, iNOS and COX-2, and induces ER stress, Ca ²⁺ release, autophagy and apoptosis. IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABL ^T315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan (HY-125474)-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia .

IM-12

Fluorescent Dyes

IM-12 GMP is IM-12 (HY-12292) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the NF-κB and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of β-catenin by inhibiting GSK3β, while also blocking the tyrosine kinase activity of p210BCR/ABL. IM-12 reduces the levels of IL-6, IL-17, NO, prostaglandin E2, iNOS and COX-2, and induces ER stress, Ca ²⁺ release, autophagy and apoptosis. IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABL ^T315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan (HY-125474)-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia .

Cat. No.	Product Name	Type

HY-Y0669

Pipecolic acid 2 Publications Verification	Biochemical Assay Reagents
Pipecolic acid is an orally bioavailable, blood-brain barrier-permeable metabolite of lysine with antioxidant, inhibitor, and inducer activity. Pipecolic acid modulates the YAP-GPX4 signaling pathway, reduces retinal vascular tube formation, and mitigates ferroptosis. Pipecolic acid potentiates voltage-sensitive Ca ²⁺ channel currents and induces neuronal apoptosis. Pipecolic acid can be used for the research of diabetic retinopathy .

Pipecolic acid

2 Publications Verification

Biochemical Assay Reagents

Pipecolic acid is an orally bioavailable, blood-brain barrier-permeable metabolite of lysine with antioxidant, inhibitor, and inducer activity. Pipecolic acid modulates the YAP-GPX4 signaling pathway, reduces retinal vascular tube formation, and mitigates ferroptosis. Pipecolic acid potentiates voltage-sensitive Ca ²⁺ channel currents and induces neuronal apoptosis. Pipecolic acid can be used for the research of diabetic retinopathy .

HY-12292G

IM-12	Biochemical Assay Reagents
IM-12 GMP is IM-12 (HY-12292) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the NF-κB and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of β-catenin by inhibiting GSK3β, while also blocking the tyrosine kinase activity of p210BCR/ABL. IM-12 reduces the levels of IL-6, IL-17, NO, prostaglandin E2, iNOS and COX-2, and induces ER stress, Ca ²⁺ release, autophagy and apoptosis. IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABL ^T315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan (HY-125474)-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia .

IM-12

Biochemical Assay Reagents

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6777R

Penicillic acid (Standard)	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Caspase Bacterial Apoptosis Antibiotic
Tetracaine (hydrochloride) (Standard) is the analytical standard of Tetracaine (hydrochloride). This product is intended for research and analytical applications. Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72109

	CACNA2D1 Protein, Human (His-SUMO) Ca2D1_HUMAN; CaCN A2; CaCNA2; Cacna2d1; CaCNL2A; Calcium channel L type alpha 2 polypeptide; Calcium channel voltage dependent alpha 2/delta subunit 1; CCHL2A; Dihydropyridine receptor alpha 2 subunit; Dihydropyridine sensitive L type Calcium channel alpha 2/delta subunit; Dihydropyridine sensitive L type Calcium channel subunits alpha 2/delta; L type Calcium channel subunit alpha 2; MHS 3; MHS3; Voltage dependent Calcium channel subunit alpha 2/delta 1; Voltage gated Calcium channel subunit alpha 2/delta 1; Voltage-dependent Calcium channel subunit delta-1; Voltage-gated Calcium channel subunit alpha-2/delta-1	Human	E. coli
	The CACNA2D1 protein, particularly its α-2/δ subunit, plays a key role in regulating calcium current density and activation/deactivation kinetics of voltage-dependent calcium channels. It contributes to excitation-contraction coupling, coordinating cellular processes. CACNA2D1 Protein, Human (His-SUMO) is the recombinant human-derived CACNA2D1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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HY-B0246S4

Carbamazepine-d4

Carbamazepine-d₄ (CBZ-d₄) is the deuterium labeled Carbamazepine (HY-B0246) . Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC₅₀ of 131 μM. Carbamazepine blocks voltage gated Na ⁺, Ca ²⁺, and K ⁺ channels, and is also a HDAC inhibitor (IC₅₀: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain.

HY-135746S

OR-1896-d3
OR-1896-d₃ is the deuterium labeled OR-1896 (HY-135746). OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 is a highly selective phosphodiesterase (PDE) III isoform inhibitor and a powerful vasodilator. OR-1896 can open ATP-sensitive K+ channels and has Ca2+-sensitizing effect. OR-1896 mitigates cardiomyocyte apoptosis, cardiac remodeling and myocardial inflammation .

Targets Recommended: Calcium Channel CRAC Channel Na+/Ca2+ Exchanger Hormone-Sensitive Lipase (HSL) CaSR Calmodulin CaMK VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12292G

IM-12	NF-κB STAT GSK-3 β-catenin Bcr-Abl	Cancer
IM-12 GMP is IM-12 (HY-12292) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the NF-κB and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of β-catenin by inhibiting GSK3β, while also blocking the tyrosine kinase activity of p210BCR/ABL. IM-12 reduces the levels of IL-6, IL-17, NO, prostaglandin E2, iNOS and COX-2, and induces ER stress, Ca ²⁺ release, autophagy and apoptosis. IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABL ^T315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan (HY-125474)-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia .

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Ca 2 sensitive

Inhibitors & Agonists

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